Results 131 to 140 of about 349,115 (258)

B cells maintain the homeostasis of splenic marginal zone antigen-presenting cells to promote the antiviral CD8⁺ T-cell response. [PDF]

Cell Mol Immunol
Liu X, Demircik F, Antipova M, Stylianakis E, Klein M, Bejarano D, Elwy A, Ebering A, Blanfeld M, Carter K, Johann L, Uhlfelder DC, Blickberndt E, Chen Y, Probst HC, Hövelmeyer N, Bopp T, Arens R, Bunse L, den Haan JMM, Gommerman JL, von Stebut E, Clausen BE, Schlitzer A, Lang KS, Su B, Backer RA, Lemmermann NA, Waisman A.   +28 more
europepmc   +1 more source

Exploring an Alternative to mRNA Vaccine Cold Chain Storage: MRNA‐Lipid Nanoparticle Stability When Dried in a Polymer Matrix

Advanced Functional Materials, EarlyView.
The nanostructure, size, and function of mRNA‐loaded lipid nanoparticles are evaluated before drying, within polymer microneedles, and after rehydration. The results reveal the polymer and LNP loadings required to recover nanostructure and preserve the delivery performance in dry‐state formulations.
Brendan P. Dyett, Shahad K. Alsaiari, John L. Daristotle, Timothy A. Forster, Alicia Lau, Dhruv Varshney, Rania Afaneh, Andrew R. Hanna, Charles Sloane, David Mankus, Haitao Yu, Jiali Zhai, DongSoo Yun, Lisa H. Tostanoski, Abigail Lytton‐Jean, Dan H. Barouch, Charlotte E. Conn, Robert Langer, Ana Jaklenec, Calum J. Drummond   +19 more
wiley   +1 more source

MHC class II presentation of FVIII-AnnexinA5 fusion proteins internalized by antigen presenting cells. [PDF]

Front Immunol
Miranda M, Leoni M, van der Zwaan C, van Bruggen R, Reutelingsperger CPM, Fijnvandraat K, Hoogendijk AJ, van den Biggelaar M, Voorberg J.   +8 more
europepmc   +1 more source

Electrostatically‐Stabilized PEG‐Free Lipid Nanoparticles for Systemic Nucleic Acid Delivery

Advanced Functional Materials, EarlyView.
This work describes non‐PEGylated layered lipid nanoparticles (nonPEG LLNPs), a gene delivery platform that improves upon standard PEGylated LNPs via electrostatic adsorption of charged polymers. nonPEG LLNPs maintain colloidal stability under biological stresses, enhance circulation time, and mitigate accelerated blood clearance and hepatic ...
Namita Nabar, Deeksha Kumaresh, Eduardo Nombera Bueno, Mae Pryor, Paula T. Hammond   +4 more
wiley   +1 more source

Dendritic cells and HIV transmission: roles and subsets of antigen-presenting cells in the human anogenital tract. [PDF]

PLoS Pathog
Buffa DJ, O'Neil TR, Vine EE, Sarkawt L, Warner van Dijk FA, Dong OA, Nasr N, Cunningham AL, Bertram KM, Harman AN.   +9 more
europepmc   +1 more source

Tuning Mechanoreceptor Signaling Enhances the Adjuvant Effect of Biomaterial Vaccines

Advanced Functional Materials, EarlyView.
Matrix stiffness serves as an independent immunological signal in biomaterial vaccines. Stiffer microporous hydrogel vaccines enhance dendritic cell maturation and migration to draining lymph nodes, promote T follicular helper cell expansion through Yap/Taz signaling, and increase antigen‐specific antibody production.
Lily Shang, Daniel P. Mayer, Prabhat K. Purbey, Yingzi Liu, Kindra Kelly‐Scumpia, Clara Kang, Natalie Tsubamoto, Dhriti Bolangadi, Iqra Arshad, Charisse Ng, Maksim V. Plikus, Dino Di Carlo, Jason S. Weinstein, Philip O. Scumpia   +13 more
wiley   +1 more source

Gut dysbiosis in a murine model of cutaneous lupus erythematosus correlates with antigen-specific T cells and antigen-presenting cells in skin. [PDF]

Sci Rep
Neff HA, Yıldız-Altay Ü, Salam N, Ward DV, Shepard D, Ramirez-Ortiz ZG, Richmond JM.   +6 more
europepmc   +1 more source

Antigen‐presenting cells in nasal allergy [PDF]

Allergy, 1999
openaire   +3 more sources

Microfluidic Nano‐Assembly of Red‐Blood‐Cell (RBC) Lipids and Components for Engineering Extracellular Vesicles

Advanced Healthcare Materials, EarlyView.
Engineered red blood cell‐derived extracellular vesicles (eRBCEVs) are synthesized via controlled microfluidic assembly from native RBC lipids, enabling tunable encapsulation of proteins, nucleic acids, nanoparticles, and viral vectors. The platform demonstrates reproducible nanoscale architecture, preserved membrane composition, and functional cargo ...
Chiranth K. Nagaraj, Xilal Y. Rima, Kim T. Nguyen, Courtney Culkins, Nana Boateng, Jacob Doon‐Ralls, Alejandro Bresolin, Xin Huang, Hong Li, Vahedi Amid, Ajeet Pal Singh, Dharti Shantaram, Anastasiia Amari, Mangesh D. Hade, Nicholas R. Merriam, Zachary D. Schultz, Scott Q. Harper, Nizar Y. Saad, Setty M. Magaña, Willa A. Hsueh, Rachel E. Kopec, Blaise R. Kimmel, Andre F. Palmer, Eduardo Reátegui   +23 more
wiley   +1 more source

DNA vaccines targeting hemagglutinin from 18 subtypes of influenza A virus to antigen-presenting cells confer broad protection. [PDF]

Mol Ther Nucleic Acids
Anderson AM, Tjärnhage E, Hinke DM, Braathen R, Grodeland G, Bogen B.   +5 more
europepmc   +1 more source