Results 81 to 90 of about 342,290 (286)

Supplementary Figure 5 from Antigen Presented by Tumors <i>In vivo</i> Determines the Nature of CD8⁺ T-Cell Cytotoxicity

, 2023
Anil Shanker, Alan D. Brooks, Kristen M. Jacobsen, John W. Wine, Robert H. Wiltrout, Hideo Yagita∥, Thomas J. Sayers   +6 more
openalex   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Flavonoids, nobiletin, heptamethoxyflavone, and genistein enhance antigen-presenting cell function in vitro

Exploration of Immunology
Aim: Antigen (Ag) presentation by Ag-presenting cells (APCs) is the first step in the generation of adaptive humoral and cellular immune responses. However, there have been few studies on the effects of flavonoids on APC function.
Yuko Tanaka, Akiko Nakamoto, Haruka Ohashi, Mariko Nakamoto, Tohru Sakai   +4 more
doaj   +1 more source

The second touch hypothesis: T cell activation, homing and polarization [v1; ref status: indexed, http://f1000r.es/2w7]

F1000Research, 2014
The second touch hypothesis states that T cell activation, proliferation, induction of homing receptors and polarization are distinguishable and, at least in part, sequential. The second touch hypothesis maintains that full T cell polarization requires T
Klaus Ley
doaj   +1 more source

Antigen Presentation by Extracellular Vesicles from Professional Antigen-Presenting Cells

Annual Review of Immunology, 2018
The initiation and maintenance of adaptive immunity require multifaceted modes of communication between different types of immune cells, including direct intercellular contact, secreted soluble signaling molecules, and extracellular vesicles (EVs). EVs can be formed as microvesicles directly pinched off from the plasma membrane or as exosomes secreted ...
Lindenbergh, Marthe F S, Stoorvogel, Willem   +1 more
openaire   +2 more sources

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Immunohistochemical analysis of Langerhans cells in chronic gingivitis using anti-CD1a antibody

Dental Research Journal, 2014
Background: The Langerhans cells (LCs) are dendritic cells (DCs) which belong to the group of antigen presenting cells (APCs). Their function is to recognize the antigen, capture it, and present it to the T lymphocytes; thus initiating an early immune ...
Shweta Jaitley, Sriram Gopu, Saraswathi T Rajasekharan, Balasundaram Sivapathasundaram   +3 more
doaj  

Large Scale Ex Vivo Expansion of γδ T cells Using Artificial Antigen-presenting Cells

, 2022
Justin C. Boucher, Bin Yu, Gongbo Li, Bishwas Shrestha, David A. Sallman, Ana Marie Landin, Cheryl A. Cox, Kumar Karyampudi, Claudio Anasetti, Marco L. Davila, Nelli Bejanyan   +10 more
openalex   +2 more sources