Results 1 to 10 of about 21,185,510 (281)
The circadian clock influences T cell responses to vaccination by regulating dendritic cell antigen processing. [PDF]
Nat Commun, 2022 Dendritic cells play a key role in processing and presenting antigens to naïve T cells to prime adaptive immunity. Circadian rhythms are known to regulate many aspects of immunity; however, the role of circadian rhythms in dendritic cell function is ...
Cervantes-Silva MP +21 more
europepmc +2 more sources
The Small GTPase Rab7 Regulates Antigen Processing in B Cells in a Possible Interplay with Autophagy Machinery [PDF]
Cells, 2023 In B cells, antigen processing and peptide-antigen (pAg) presentation is essential to ignite high-affinity antibody responses with the help of cognate T cells.
Marika Runsala +7 more
doaj +2 more sources
Antigen processing and presentation in cancer immunotherapy. [PDF]
J Immunother Cancer, 2020 Background Knowledge about and identification of T cell tumor antigens may inform the development of T cell receptor-engineered adoptive cell transfer or personalized cancer vaccine immunotherapy.
Lee MY, Jeon JW, Sievers C, Allen CT.
europepmc +2 more sources
Rewiring tumor visibility: The immunopeptidome as a dynamic interface between antigen processing, microenvironmental stress, and immune recognition [PDF]
Frontiers in OncologyThe tumor immunopeptidome dictates whether malignant cells remain visible or invisible to immune surveillance, yet its regulation extends far beyond canonical antigen processing. Here, we synthesize recent insights into how proteasomes, immunoproteasomes,
Kangkang Zhao +5 more
doaj +2 more sources
Pathways of Antigen Processing [PDF]
Annual Review of Immunology, 2013 T cell recognition of antigen-presenting cells depends on their expression of a spectrum of peptides bound to major histocompatibility complex class I (MHC-I) and class II (MHC-II) molecules. Conversion of antigens from pathogens or transformed cells into MHC-I- and MHC-II-bound peptides is critical for mounting protective T cell responses, and similar
Janice S, Blum +2 more
openaire +3 more sources
Improving MHC class I antigen-processing predictions using representation learning and cleavage site-specific kernels [PDF]
Cell Reports: Methods, 2022 Summary: In this work, we propose a new deep-learning model, MHCrank, to predict the probability that a peptide will be processed for presentation by MHC class I molecules.
Patrick J. Lawrence, Xia Ning
doaj +2 more sources
Targeting the antigen processing and presentation pathway to overcome resistance to immune checkpoint therapy [PDF]
Frontiers in Immunology, 2022 Despite the significant clinical advances with the use of immune checkpoint inhibitors (ICIs) in a wide range of cancer patients, response rates to the therapy are variable and do not always result in long-term tumor regression.
Silvia D’Amico +9 more
doaj +2 more sources
Cells, 2022 Vaccine therapy is a promising method of research to promote T cell immune response and to develop novel antitumor immunotherapy protocols. Accumulating evidence has shown that autophagy is involved in antigen processing and presentation to T cells.
Leïla Fonderflick +5 more
doaj +1 more source
Cancers, 2021 Simple Summary A new class of drugs, termed Immune Checkpoint Inhibitors, has revolutionized cancer therapy during the last few years. Unfortunately, these drugs are only effective for a subset of patients and cancer types. Recent work has suggested that
A. Mpakali, E. Stratikos
semanticscholar +1 more source