The Small GTPase Rab7 Regulates Antigen Processing in B Cells in a Possible Interplay with Autophagy Machinery [PDF]
Cells, 2023 In B cells, antigen processing and peptide-antigen (pAg) presentation is essential to ignite high-affinity antibody responses with the help of cognate T cells.
Marika Runsala +7 more
doaj +2 more sources
Tumor-Derived Microvesicles Enhance Cross-Processing Ability of Clinical Grade Dendritic Cells [PDF]
Frontiers in Immunology, 2018 Tumor cells release extracellular microvesicles (MVs) in the microenvironment to deliver biological signals to neighboring cells as well as to cells in distant tissues.
Marco Dionisi +15 more
doaj +3 more sources
Determination of a Predictive Cleavage Motif for Eluted Major Histocompatibility Complex Class II Ligands [PDF]
Frontiers in Immunology, 2018 CD4+ T cells have a major role in regulating immune responses. They are activated by recognition of peptides mostly generated from exogenous antigens through the major histocompatibility complex (MHC) class II pathway.
Sinu Paul +10 more
doaj +8 more sources
Improving MHC class I antigen-processing predictions using representation learning and cleavage site-specific kernels [PDF]
Cell Reports: Methods, 2022 Summary: In this work, we propose a new deep-learning model, MHCrank, to predict the probability that a peptide will be processed for presentation by MHC class I molecules.
Patrick J. Lawrence, Xia Ning
doaj +2 more sources
Rewiring tumor visibility: The immunopeptidome as a dynamic interface between antigen processing, microenvironmental stress, and immune recognition [PDF]
Frontiers in OncologyThe tumor immunopeptidome dictates whether malignant cells remain visible or invisible to immune surveillance, yet its regulation extends far beyond canonical antigen processing. Here, we synthesize recent insights into how proteasomes, immunoproteasomes,
Kangkang Zhao +5 more
doaj +2 more sources
Targeting the antigen processing and presentation pathway to overcome resistance to immune checkpoint therapy [PDF]
Frontiers in Immunology, 2022 Despite the significant clinical advances with the use of immune checkpoint inhibitors (ICIs) in a wide range of cancer patients, response rates to the therapy are variable and do not always result in long-term tumor regression.
Silvia D’Amico +9 more
doaj +2 more sources
Cells, 2022 Vaccine therapy is a promising method of research to promote T cell immune response and to develop novel antitumor immunotherapy protocols. Accumulating evidence has shown that autophagy is involved in antigen processing and presentation to T cells.
Leïla Fonderflick +5 more
doaj +1 more source
Molecular tracking devices quantify antigen distribution and archiving in the murine lymph node
eLife, 2021 The detection of foreign antigens in vivo has relied on fluorescent conjugation or indirect read-outs such as antigen presentation. In our studies, we found that these widely used techniques had several technical limitations that have precluded a ...
Shannon M Walsh +9 more
doaj +1 more source
The ER folding sensor UGGT1 acts on TAPBPR-chaperoned peptide-free MHC I
eLife, 2023 Adaptive immune responses are triggered by antigenic peptides presented on major histocompatibility complex class I (MHC I) at the surface of pathogen-infected or cancerous cells.
Lina Sagert +5 more
doaj +1 more source
The Function of Immunoproteasomes—An Immunologists’ Perspective
Cells, 2021 Proteasomes are responsible for intracellular proteolysis and play an important role in cellular protein homeostasis. Cells of the immune system assemble a specialized form of proteasomes, known as immunoproteasomes, in which the constitutive catalytic ...
Bart L. van den Eshof +4 more
doaj +1 more source