Results 11 to 20 of about 19,444,475 (370)
Pathways of Antigen Processing [PDF]
Annual Review of Immunology, 2013 T cell recognition of antigen-presenting cells depends on their expression of a spectrum of peptides bound to major histocompatibility complex class I (MHC-I) and class II (MHC-II) molecules. Conversion of antigens from pathogens or transformed cells into MHC-I- and MHC-II-bound peptides is critical for mounting protective T cell responses, and similar
Janice S, Blum +2 more
openaire +3 more sources
The circadian clock influences T cell responses to vaccination by regulating dendritic cell antigen processing. [PDF]
Nat Commun, 2022 Dendritic cells play a key role in processing and presenting antigens to naïve T cells to prime adaptive immunity. Circadian rhythms are known to regulate many aspects of immunity; however, the role of circadian rhythms in dendritic cell function is ...
Cervantes-Silva MP +21 more
europepmc +2 more sources
Footprints of antigen processing boost MHC class II natural ligand predictions [PDF]
Genome Medicine, 2018 Major histocompatibility complex class II (MHC-II) molecules present peptide fragments to T cells for immune recognition. Current predictors for peptide to MHC-II binding are trained on binding affinity data, generated in vitro and therefore lacking ...
Carolina Barra +7 more
openalex +2 more sources
Antigen processing and presentation in cancer immunotherapy. [PDF]
J Immunother Cancer, 2020 Background Knowledge about and identification of T cell tumor antigens may inform the development of T cell receptor-engineered adoptive cell transfer or personalized cancer vaccine immunotherapy.
Lee MY, Jeon JW, Sievers C, Allen CT.
europepmc +2 more sources
Cancers, 2021 Simple Summary A new class of drugs, termed Immune Checkpoint Inhibitors, has revolutionized cancer therapy during the last few years. Unfortunately, these drugs are only effective for a subset of patients and cancer types. Recent work has suggested that
A. Mpakali, E. Stratikos
semanticscholar +1 more source
Emerging Microbes and Infections, 2020 Burkholderia cenocepacia is an emerging opportunistic pathogen for people with cystic fibrosis and chronic granulomatous disease. Intracellular survival in macrophages within a membrane-bound vacuole (BcCV) that delays acidification and maturation into ...
Roberto Rosales-Reyes +10 more
doaj +1 more source
The ER Aminopeptidases, ERAP1 and ERAP2, synergize to self-modulate their respective activities
Frontiers in Immunology, 2022 IntroductionCritical steps in Major Histocompatibility Complex Class I (MHC-I) antigen presentation occur in the endoplasmic reticulum (ER). In general, peptides that enter the ER are longer than the optimal length for MHC-I binding.
Adrian Martín-Esteban +6 more
doaj +1 more source
Autophagy proteins stabilize pathogen-containing phagosomes for prolonged MHC II antigen processing [PDF]
Journal of Cell Biology, 2013 A subset of phagosomes in human macrophages and dendritic cells that is marked by a coat of autophagy-related proteins maintains phagocytosed antigens for prolonged presentation on MHC class II molecules.
Susana Romão +10 more
openalex +2 more sources
Siglec Receptors Modulate Dendritic Cell Activation and Antigen Presentation to T Cells in Cancer
Frontiers in Cell and Developmental Biology, 2022 Interactions between sialylated glycans and sialic acid-binding immunoglobulin-like lectin (Siglec) receptors have been recently described as potential new immune checkpoint that can be targeted to improve anticancer immunity.
Jinyu Wang +14 more
doaj +1 more source