Neo-Splicetopes in Tumor Therapy: A Lost Case?
Frontiers in Immunology, 2022 Proteasome generates spliced peptides by ligating two distant cleavage products in a reverse proteolysis reaction. The observation that CD8+ T cells recognizing a spliced peptide induced T cell rejection in a melanoma patient following adoptive T cell ...
Peter M. Kloetzel
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Can ERAP1 and ERAP2 Form Functional Heterodimers? A Structural Dynamics Investigation
Frontiers in Immunology, 2022 Endoplasmic reticulum aminopeptidases 1 and 2 (ERAP1 and ERAP2) play important roles in the generation of antigenic peptides presented by Major Histocompatibility Class I (MHCI) molecules and indirectly regulate adaptive immune responses.
Athanasios Papakyriakou +3 more
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Proteases: essential actors in processing antigens and intracellular Toll-like receptors
Frontiers in Immunology, 2013 MHC class II molecules expressed by professional antigen presenting cells (pAPCs) such as macrophages, B cells and dendritic cells (DCs) play a fundamental role in presenting peptides to CD4+ T cells.
Bénédicte eManoury
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A loop structure allows TAPBPR to exert its dual function as MHC I chaperone and peptide editor
eLife, 2020 Adaptive immunity vitally depends on major histocompatibility complex class I (MHC I) molecules loaded with peptides. Selective loading of peptides onto MHC I, referred to as peptide editing, is catalyzed by tapasin and the tapasin-related TAPBPR.
Lina Sagert +3 more
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The Function of Immunoproteasomes—An Immunologists’ Perspective
Cells, 2021 Proteasomes are responsible for intracellular proteolysis and play an important role in cellular protein homeostasis. Cells of the immune system assemble a specialized form of proteasomes, known as immunoproteasomes, in which the constitutive catalytic ...
Bart L. van den Eshof +4 more
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Current Concepts of Antigen Cross-Presentation
Frontiers in Immunology, 2018 Dendritic cells have the ability to efficiently present internalized antigens on major histocompatibility complex (MHC) I molecules. This process is termed cross-presentation and is important role in the generation of an immune response against viruses ...
Maria Embgenbroich, Sven Burgdorf
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The Antigen Processing and Presentation Machinery in Lymphatic Endothelial Cells
Frontiers in Immunology, 2019 Until a few years ago, lymphatic vessels and lymphatic endothelial cells (LEC) were viewed as part of a passive conduit for lymph and immune cells to reach lymph nodes (LN).
L. Santambrogio +2 more
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Dysfunction of antigen processing and presentation by dendritic cells in cancer.
Molecular Immunology, 2019 The ability to mount an effective anti-tumor immune response requires coordinate control of CD4 T cell and CD8 T cell function by antigen presenting cells (APCs). Unfortunately, tumors create an immunosuppressive microenvironment that helps protect tumor
Joanna Bandola-Simon, P. Roche
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The ER Aminopeptidases, ERAP1 and ERAP2, synergize to self-modulate their respective activities
Frontiers in Immunology, 2022 IntroductionCritical steps in Major Histocompatibility Complex Class I (MHC-I) antigen presentation occur in the endoplasmic reticulum (ER). In general, peptides that enter the ER are longer than the optimal length for MHC-I binding.
Adrian Martín-Esteban +6 more
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Selection of immunodominant epitopes during antigen processing is hierarchical.
Molecular Immunology, 2019 MHC II proteins present processed antigens to CD4 + T cells through a complex set of events and players that include chaperons and accessory molecules.
S. Sadegh-Nasseri, Aeryon Kim
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