Results 31 to 40 of about 21,185,510 (281)

Cross-presentation of cell-associated antigens by MHC class I in dendritic cell subsets

Frontiers in Immunology, 2015
Dendritic cells have the unique ability to pick up dead cells carrying antigens in tissue and migrate to the lymph nodes where they can cross-present cell-associated antigens by MHC class I to CD8+ T cells. There is strong in vivo evidence that the mouse
Enric eGutiérrez-Martínez, Remi ePlanès, Giorgio eAnselmi, Matthew eReynolds, Shinelle eMenezes, Adiko Assi Aimé Cézaire, Adiko Assi Aimé Cézaire, Loredana eSaveanu, Loredana eSaveanu, Pierre eGuermonprez   +9 more
doaj   +1 more source

Binding of the von Willebrand Factor A Domain of Capillary Morphogenesis Protein 2 to Anthrax Protective Antigen Vaccine Reduces Immunogenicity in Mice

mSphere, 2020
Protective antigen (PA) is a component of anthrax toxin that can elicit toxin-neutralizing antibody responses. PA is also the major antigen in the current vaccine to prevent anthrax, but stability problems with recombinant proteins have complicated the ...
Fabiana Freire Mendes de Oliveira, Sireesha Mamillapalli, Srinivas Gonti, Robert N. Brey, Han Li, Jarad Schiffer, Arturo Casadevall, James G. Bann   +7 more
doaj   +1 more source

Toward a network model of MHC class II-restricted antigen processing

Frontiers in Immunology, 2013
The standard model of Major Histocompatibility Complex class II (MHCII)-restricted antigen processing depicts a straightforward, linear pathway: Internalized antigens are converted into peptides that load in a chaperone dependent manner onto nascent ...
Laurence C Eisenlohr, Michael A Miller, Asha Purnima Veerappan Ganesan   +2 more
doaj   +1 more source

Siglec Receptors Modulate Dendritic Cell Activation and Antigen Presentation to T Cells in Cancer

Frontiers in Cell and Developmental Biology, 2022
Interactions between sialylated glycans and sialic acid-binding immunoglobulin-like lectin (Siglec) receptors have been recently described as potential new immune checkpoint that can be targeted to improve anticancer immunity.
Jinyu Wang, Michela Manni, Anne Bärenwaldt, Ronja Wieboldt, Nicole Kirchhammer, Robert Ivanek, Robert Ivanek, Michal Stanczak, Alfred Zippelius, Alfred Zippelius, David König, David König, Natalia Rodrigues Manutano, Heinz Läubli, Heinz Läubli   +14 more
doaj   +1 more source

Footprints of antigen processing boost MHC class II natural ligand predictions

Genome Medicine, 2018
Major histocompatibility complex class II (MHC-II) molecules present peptide fragments to T cells for immune recognition. Current predictors for peptide to MHC-II binding are trained on binding affinity data, generated in vitro and therefore lacking ...
C. Barra, Bruno Alvarez, S. Paul, A. Sette, Bjoern Peters, M. Andreatta, S. Buus, M. Nielsen   +7 more
semanticscholar   +1 more source

HLA class II antigen-processing pathway in tumors: Molecular defects and clinical relevance

Oncoimmunology, 2017
The human leukocyte antigen (HLA) class II antigen-processing machinery (APM) presents to cognate CD4+ T-cells antigenic peptides mainly generated from exogeneous proteins in the endocytic compartment.
B. Seliger, M. Kloor, S. Ferrone
semanticscholar   +1 more source

Estimation of endoplasmic reticulum aminopeptidase 1 level of expression in lesional and nonlesional skin of psoriatic patients and healthy controls

Journal of the Egyptian Women’s Dermatologic Society, 2021
Background Psoriasis is a chronic inflammatory autoimmune disease of the skin, in which an elevated expression of endoplasmic reticulum aminopeptidase 1 (ERAP1), an enzyme involved in the final processing of major histocompatibility complex-I ligands ...
Dina Metwally, Laila A Rashed, Amul M Badr, Doaa M Elqadi, Rana F Hilal   +4 more
doaj   +1 more source

Inhibiting DNA methylation activates cancer testis antigens and expression of the antigen processing and presentation machinery in colon and ovarian cancer cells

PLoS ONE, 2017
Innovative therapies for solid tumors are urgently needed. Recently, therapies that harness the host immune system to fight cancer cells have successfully treated a subset of patients with solid tumors.
C. Siebenkäs, Katherine B. Chiappinelli, Angela A. Guzzetta, A. Sharma, J. Jeschke, Rajita Vatapalli, S. Baylin, N. Ahuja   +7 more
semanticscholar   +1 more source

Genetics of antigen processing and presentation

Immunogenetics, 2018
Immune response to disease requires coordinated expression of an army of molecules. The highly polymorphic MHC class I and class II molecules are key to control of specificity of antigen presentation.
A. Kelly, J. Trowsdale
semanticscholar   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source