Analysis of host responses to Mycobacterium tuberculosis antigens in a multi-site study of subjects with different TB and HIV infection states in sub-Saharan Africa. [PDF]
, 2013 BACKGROUND: Tuberculosis (TB) remains a global health threat with 9 million new cases and 1.4 million deaths per year. In order to develop a protective vaccine, we need to define the antigens expressed by Mycobacterium tuberculosis (Mtb), which are ...
AA Odutola +46 more
core +18 more sources
Immunoprotection against Cryptococcosis Offered by Znf2 Depends on Capsule and the Hyphal Morphology
mBio, 2022 Systemic cryptococcosis is fatal without treatment. Globally, this disease kills 180,000 of the 225,000 infected people each year, even with the use of antifungal therapies. Currently, there is no vaccine to prevent cryptococcosis.
Jianfeng Lin +5 more
doaj +1 more source
Mathematical Modeling Insights into Improving CAR T cell Therapy for Solid Tumors: Antigen Heterogeneity and Bystander Effects [PDF]
npj Systems Biology and Applications, 10(1), 105 (2024), 2023 As an adoptive cellular therapy, Chimeric Antigen Receptor T-cell (CAR T-cell) therapy has shown remarkable success in hematological malignancies, but only limited efficacy against solid tumors. Compared with blood cancers, solid tumors present a unique set of challenges that ultimately neutralize the function of CAR T-cells.
arxiv +1 more source
Serum IgG antibodies against Helicobacter pylori low molecular weight antigens 50kDa, 30kDa and Urease A 26 kDa, along with vacuolating cytotoxin A are associated with the outcome of the infection [PDF]
Vojnosanitetski Pregled, 2020 Background/Aim. We designed and conducted this study due to the fact that results of the previous studies about seroreactivity to low-molecular-weight Helicobacter pylori antigens, cytotoxin-associated gene A (CagA), vacuolating cytotoxin A (VacA) in ...
Manojlović Nebojša +3 more
doaj +1 more source
Journal of Applied Veterinary Sciences, 2020 The standard serological test such as Rose Bengal Plate Test (RBPT) is routinely used for the diagnosis of brucellosis. This test depends on the agglutination of colored particulate antigen (killed Brucella organisms) by the antibodies present in sera ...
Lamees A. El-Tantawy +3 more
doaj +1 more source
Annals of Clinical Microbiology, 2022 Background: We evaluated the diagnostic performance of the Exdia COVID-19 antigen test (Exdia Ag; Precision Biosensor Inc., Korea) as a point-of-care (POC) test performed in the emergency department (ED) for the rapid detection of severe acute ...
In Young Yoo +5 more
doaj +1 more source
Soluble CD4 antigens in the cerebrospinal fluid as a marker of lymphocytic infiltration of the central nervous system [PDF]
Vojnosanitetski Pregled, 2004 Early diagnosis of the central nervous system (CNS) infections is a precondition of their successful treatment. However, the essential standard examination of the cerebrospinal fluid (CSF) is sometimes neither specific enough to define their basic nature,
Vrbić Miodrag +8 more
doaj +1 more source
New 'Antigens' in Membranous Nephropathy.
Journal of the American Society of Nephrology, 2020 Membranous nephropathy (MN) occurs due to deposition of immune complexes along the subepithelial region of glomerular basement membrane. Two previously identified target antigens for the immune complexes, PLA2R (identified in 2009) and THSD7A (in 2014 ...
S. Sethi
semanticscholar +1 more source
Frontiers in Immunology, 2021 Aspergillus fumigatus causes life-threatening opportunistic infections in immunocompromised patients. As therapeutic outcomes of invasive aspergillosis (IA) are often unsatisfactory, the development of targeted immunotherapy remains an important goal ...
Lukas Page +21 more
doaj +1 more source