Identification of Circulating Bacterial Antigens by
mBio, 2011 Detection of microbial antigens in clinical samples can lead to rapid diagnosis of an infection and administration of appropriate therapeutics. A major barrier in diagnostics development is determining which of the potentially hundreds or thousands of ...
Dana E. Nuti +13 more
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Lipopolysaccharide O-antigens-bacterial glycans made to measure. [PDF]
J Biol Chem, 2020 Lipopolysaccharides are critical components of bacterial outer membranes. The more conserved lipid A part of the lipopolysaccharide molecule is a major element in the permeability barrier imposed by the outer membrane and offers a pathogen-associated ...
Whitfield C, Williams DM, Kelly SD.
europepmc +2 more sources
Vaccines, 2020 This study was designed to evaluate the immunogenicity and protective efficacy of two VP1 chimeric antigens of bacterial ghosts. Inoculation of the two VP1 chimeric antigens of bacterial ghosts into BALB/c mice markedly elicited humoral and mucosal ...
Saisai Gong +11 more
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Antibody-guided identification of Achromobacter xylosoxidans protein antigens in cystic fibrosis [PDF]
mSpherePersistent bacterial airway infection is a hallmark feature of cystic fibrosis (CF). Achromobacter spp. are gram-negative rods that can cause persistent airway infection in people with CF (pwCF), but the knowledge of host immune responses to these ...
Cecilia Sahl +3 more
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Naturally Acquired Human Immunity to Pneumococcus Is Dependent on Antibody to Protein Antigens.
PLoS Pathogens, 2017 Naturally acquired immunity against invasive pneumococcal disease (IPD) is thought to be dependent on anti-capsular antibody. However nasopharyngeal colonisation by Streptococcus pneumoniae also induces antibody to protein antigens that could be ...
Robert Wilson +11 more
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MicroRNA-762 is upregulated in human corneal epithelial cells in response to tear fluid and Pseudomonas aeruginosa antigens and negatively regulates the expression of host defense genes encoding RNase7 and ST2. [PDF]
, 2013 Mucosal surfaces regulate defenses against infection and excessive inflammation. We previously showed that human tears upregulated epithelial expression of genes encoding RNase7 and ST2, which inhibited Pseudomonas aeruginosa invasion of human corneal ...
Chan, Gary +5 more
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Phenotypic and genotypic characterization of locally isolated Salmonella strains used in preparation of Salmonella antigens in Egypt [PDF]
Veterinary World, 2016 Aim: This work was conducted to study the phenotypic and genotypic characterization of locally isolated Salmonella strains (Salmonella Pullorum, Salmonella Enteritidis, and Salmonella Typhimurium) from poultry used in the preparation of Salmonella ...
Hazem Mohammed Ibrahim +3 more
doaj +1 more source
Glycosylation of bacterial antigens changes epitope patterns
Frontiers in Immunology, 2023 IntroductionUnlike glycosylation of proteins expressed in mammalian systems, bacterial glycosylation is often neglected in the development of recombinant vaccines.MethodsHere, we compared the effects of glycosylation of YghJ, an Escherichia coli protein ...
Karolin Kern +17 more
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Polysaccharide Vaccines: A Perspective on Non-Typhoidal Salmonella
Polysaccharides, 2021 Polysaccharides are often the most abundant antigens found on the extracellular surfaces of bacterial cells. These polysaccharides play key roles in interactions with the outside world, and for many bacterial pathogens, they represent what is presented ...
Sumudu R. Perera +2 more
doaj +1 more source
Antigenic Variation in Bacterial Pathogens [PDF]
Microbiology Spectrum, 2016 ABSTRACT Antigenic variation is a strategy used by a broad diversity of microbial pathogens to persist within the mammalian host. Whereas viruses make use of a minimal proofreading capacity combined with large amounts of progeny to use random mutation for variant generation, antigenically variant bacteria have evolved mechanisms ...
Palmer, Guy H +2 more
openaire +4 more sources