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Epitopes identified in GAPDH from Clostridium difficile recognized as common antigens with potential autoimmunizing properties

open access: yesScientific Reports, 2018
Clostridium difficile (CD) infections are a growing threat due to the strain resistance to antibiotic treatment and the emergence of hypervirulent strains.
Agnieszka Razim   +9 more
doaj   +1 more source

Label-Free Immunosensor Based on Polyaniline-Loaded MXene and Gold-Decorated β-Cyclodextrin for Efficient Detection of Carcinoembryonic Antigen

open access: yesBiosensors, 2022
Multiple strategies have been employed to improve the performance of label-free immunosensors, among which building highly conductive interfaces and introducing suitable biocompatible carriers for immobilizing antibodies or antigens are believed to be ...
Qi Wang, Huaqian Xin, Zhou Wang
doaj   +1 more source

A blood-based transcriptomic signature stratifies severe Crohn’s disease and defines potentially targetable therapeutic pathways

open access: yesFrontiers in Gastroenterology, 2023
IntroductionDespite advances in medical therapy, many patients with Crohn’s disease (CD) ultimately require surgery for disease management. Identifying the underlying molecular pathways for subgroup stratification is critical to the improvement of ...
Rivkah Gonsky   +8 more
doaj   +1 more source

Symposium 8: Nutrition in diabetes and celiac disease

open access: yesRevista de la Sociedad Argentina de Diabetes, 2020
Symposium 8: Nutritional treatment of diabetes: new horizons Nutrition in diabetes and celiac disease The existing genetic association between type 1 Diabetes Mellitus (T1D) and Celiac Disease (CD) has led to hypothesize about a possible common ...
Marta Milikowski
doaj   +1 more source

Development of an Electrochemical Immunosensor for Specific Detection of Visceral Leishmaniasis Using Gold-Modified Screen-Printed Carbon Electrodes

open access: yesBiosensors, 2020
Visceral leishmaniasis is a reemerging neglected tropical disease with limitations for its diagnosis, including low concentration of antibodies in the serum of asymptomatic patients and cross-reactions.
Beatriz R. Martins   +13 more
doaj   +1 more source

Investigating the potential impact of post translational modification of auto-antigens by tissue transglutaminase on humoral islet autoimmunity in type 1 diabetes

open access: yesMetabolism Open, 2020
Background: Post-translational modification (PTM) of antigens plays a role in the pathogenesis of many autoimmune disorders. In coeliac disease (CD), tissue transglutaminase (tTG) deamidates gliadin peptides to activate the immune response against the ...
Catherine Donnelly, Alistair Williams
doaj   +1 more source

Overview of Celiac Disease in Russia: Regional Data and Estimated Prevalence

open access: yesJournal of Immunology Research, 2017
Celiac disease (CD) is an autoimmune enteropathy triggered by the ingestion of dietary gluten from some cereals mainly in individuals carrying the HLA-DQ2 and/or HLA-DQ8 haplotypes. As an autoimmune disease, CD is manifested in the small intestine in the
Lyudmila V. Savvateeva   +3 more
doaj   +1 more source

Influence of the Clinical Status on Stress Reticulocytes, CD 36 and CD 49d of SSFA2 Homozygous Sickle Cell Patients Followed in Abidjan

open access: yesAdvances in Hematology, 2014
Background and Objectives. Interactions between sickle cells involving CD 49d, CD36, and the vascular endothelium may initiate vasoocclusion leading to acute painful episodes and multiple organ failure. Materials and Methods.
Duni Sawadogo   +5 more
doaj   +1 more source

Disease-specific B cell clones are shared between patients with Crohn’s disease

open access: yesNature Communications
B cells have important functions in gut homeostasis, and dysregulated B cell populations are frequently observed in patients with inflammatory bowel diseases, including both ulcerative colitis (UC) and Crohn’s disease (CD). How these B cell perturbations
Prasanti Kotagiri   +20 more
doaj   +1 more source

Recombinant proteins as promising antigens applied to the immunodiagnosis of Chagas disease: a scoping review

open access: yesFrontiers in Microbiology
Chagas disease (CD), caused by the protozoan Trypanosoma cruzi, is an important public health problem, occurring mainly in Latin America. The disease has a major social and economical effect, negatively impacting the life of the infected individuals, and
Carlos Ananias Aparecido Resende   +18 more
doaj   +1 more source

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