Results 191 to 200 of about 1,666,323 (310)

FOXM1 Protects Against Myocardial Ischemia‐Reperfusion Injury in Rodent and Porcine Models by Suppressing MKRN1‐Dependent LKB1 Ubiquitination

Advanced Science, EarlyView.
FOXM1 maintains mitochondrial bioenergetic function by inhibiting MKRN1‐mediated ubiquitination of LKB1 in cardiomyocytes. Loss of FOXM1 in cardiomyocytes results in upregulation of MKRN1, which enhances LKB1 ubiquitination and disrupts AMPK signaling and energy metabolism pathways. Conversely, FOXM1 overexpression preserves mitochondrial bioenergetics
Shuai Song, Xiaokai Zhang, Zihang Huang, Zhiqiang Pei, Linqi Zeng, Fengze Cai, Tongyao Wang, Mohan Li, Chenyan Liu, Yining Song, Jiahao Guo, Hao Lu, Xinyu Weng, Li Shen, Xiaochun Zhang, Xingxing Cai, Aijun Sun, Junbo Ge   +17 more
wiley   +1 more source

Biocompatible Mesoporous Materials for Bone Therapy

Advanced Science, EarlyView.
Biocompatible mesoporous materials (BMMs), characterized by high specific surface area, tunable pore size, different shapes and structures, and multidimensional functionalized modifications, have revolutionary applications in treating bone‐related diseases.
Biao Yu, Yan Wu, Yang Hong, Peng Wang, Xiaowen Liu, Yonghui Deng, Jiacan Su   +6 more
wiley   +1 more source

Detection of cytoplasmic CD antigens within normal human peripheral blood leucocytes

Immunology, 2003
G. Sandilands, Birgit Hauffe, Elizabeth H Loudon, Andrew G. Marsh, Anna Gondowidjojo, C. Campbell, Roderick K. Ferrier, Martina E. Rodie   +7 more
semanticscholar   +1 more source

Prevalence of anti-Trypanosoma cruzi and anti-Leishmania infantum antibodies in domestic dogs from Tremedal, Bahia: insights from the Oxente Chagas Bahia Project. [PDF]

Parasit Vectors
Pavan TBS, Vasconcelos LCM, Serrano IM, Campos DAA, Silva ÂAO, Ferreira RQV, Sampaio DD, Siqueira IC, Santos FLN.   +8 more
europepmc   +1 more source

Repositioning Antimicrobial Peptides Against WHO‐Priority Fungi

Advanced Science, EarlyView.
The growing burden of drug‐resistant fungal infections, driven by pathogens such as Candida auris, Cryptococcus neoformans, and Aspergillus fumigatus, underscores the urgent need for novel antifungal therapies. This review explores antimicrobial peptides as promising agents with membrane‐disruptive activity, immunomodulatory properties, and delivery ...
Cesar Augusto Roque‐Borda, Kaila Petronila Medina‐Alarcón, João Paulo Soler Gonçalves Pereira, Thais Cristina dos Anjos Sevilhano, Brigitte Aguilar‐Morón, Fernando Díaz‐Cárdenas, Lucas Silva da Cruz, Francisco Humberto Xavier‐Júnior, Eduardo Festozo Vicente, João Perdigão, Beatriz G. de la Torre, Fernando Albericio, Fernando Rogério Pavan   +12 more
wiley   +1 more source

Autophagy in inflammatory bowel disease: immunization, etiology, and therapeutic potential. [PDF]

Front Immunol
Miao ZX, Meng H, Wang J, Hou XT, Cheng WW, Liu BH, Zhang QG, Yuan S.   +7 more
europepmc   +1 more source

Three‐Channel Electron Engineered Fe‐88A@CeO2/CDs Nanozyme with Enhanced Oxidase‐Like Activity for Efficient Biomimetic Catalysis

Advanced Science, EarlyView.
xx xx. Abstract Iron‐based metal‐organic framework (MOF) nanozymes have garnered considerable attention owing to a large specific surface area, adjustable porosity, large Fe‐O clusters, and unsaturated Fe sites. However, the sluggish charge‐transfer rate and restricted active sites of the nanozymes lead to poor enzyme‐like activity and further impede ...
Kai Liu, Haibing Zhu, Feng Shi, Juan Li, Xiang Li, Zijun Lai, Haibo Li, Hao Zeng, Zhanjun Yang, Huan Pang   +9 more
wiley   +1 more source

Diagnostic Challenges in Enteropathies: A Histopathological Review. [PDF]

Diagnostics (Basel)
Enache I, Nedelcu IC, Balaban M, Balaban DV, Popp A, Jinga M.   +5 more
europepmc   +1 more source

Elementary immunology [PDF]

, 2017
Gogolák, Péter, Koncz, Gábor
core  

Emerging cGAS‐STING Agonist‐Based Nanotherapeutics: Mechanistic Insights and Applications in Cancer Combination Therapy

Advanced Science, EarlyView.
This review summarizes recent advances in cGAS‐STING agonist‐based nanotherapeutics for cancer combination therapy. It explores nanoparticle‐mediated delivery strategies, underlying molecular mechanisms, and combinatorial applications with chemotherapy, radiotherapy, targeted therapy, phototherapy, sonodynamic therapy, and immunotherapy.
Zhaomeng Wang, Yongjun Wang, Zhonggui He, Caigang Liu   +3 more
wiley   +1 more source