Results 91 to 100 of about 33,041 (261)

Table_3_Causal effects of immune cell surface antigens and functional outcome after ischemic stroke: a Mendelian randomization study.xlsx

ObjectiveWhile observational studies link immune cells with post-stroke functional outcome, the underlying immune mechanisms are not well understood.
Guohua Yu (176526), Yize Cai (18173314), Keqi Wan (18173311), Zhen Feng (298259), Chafeng Zheng (12980275), Jiawei Gui (18173308), Weiming Sun (3488033), Lang Shuai (7515551), Xiangli Dong (7515548)   +8 more
core   +1 more source

Increased T Cell Proliferative Responses to Islet Antigens Identify Clinical Responders to Anti-CD20 Monoclonal Antibody (Rituximab) Therapy in Type 1 Diabetes

, 2011
Type 1 diabetes mellitus is believed to be due to the autoimmune destruction of β-cells by T lymphocytes, but a single course of rituximab, a monoclonal anti-CD20 B lymphocyte Ab, can attenuate C-peptide loss over the first year of disease.
Zhugong Liu, Lisa M. Spain, Mark D. Pescovitz, Type 1 Diabet TrialNet Anti-CD20, Lachin, John M, Kevan C. Herold, Dosch, H Michael, Pescovitz, Mark D, Adam Asare, Kasia Bourcier, null null, H. Michael Dosch, McGee, Paula, Liu, Zhugong, Heidi Krause-Steinrauf, John M. Lachin, Herold, Kevan C, Bourcier, Kasia, Krause-Steinrauf, Heidi, Spain, Lisa M, Paula McGee, Asare, Adam   +21 more
core   +1 more source

Enhancement of immune checkpoint inhibitor efficacy by DHX58+ SELL+ T cells in advanced gastric cancer

VIEW, EarlyView.
We created a coculture system using patient‐derived organoids (PDOs) and tumor‐infiltrating lymphocytes (TILs) that mimics important interactions between PDOs and TILs in the presence of various ICIs. Our findings reveal that CD62L+ T cells, activated by CD44+ cancer stem cells (CSCs), facilitate tumor regression in samples sensitive to ICIs, which is ...
Jie Chen, Youdong Liu, Hongda Pan, Tianyi Cai, Mingde Zang, Xiaowen Liu, Ziwen Long, Xin Fan, Jun Lu, Fenglin Liu   +9 more
wiley   +1 more source

Table_4_Causal effects of immune cell surface antigens and functional outcome after ischemic stroke: a Mendelian randomization study.xlsx

ObjectiveWhile observational studies link immune cells with post-stroke functional outcome, the underlying immune mechanisms are not well understood.
Guohua Yu (176526), Yize Cai (18173314), Keqi Wan (18173311), Zhen Feng (298259), Chafeng Zheng (12980275), Jiawei Gui (18173308), Weiming Sun (3488033), Lang Shuai (7515551), Xiangli Dong (7515548)   +8 more
core   +1 more source

Human T cell responses to dengue virus antigens. Proliferative responses and interferon gamma production

, 2008
The severe complications of dengue virus infections, hemorrhagic manifestations and shock, are more commonly observed during secondary dengue virus infections than during primary infections. It has been speculated that these complications are mediated by
Nisalak, Ananda, Nimmannitya, Suchitra, Kurane, Ichiro, Ennis, Francis A., Meager, Anthony, Hoke, Charles H., Innis, Bruce L.   +6 more
core   +1 more source

Peptide‐directed nanovehicles enabling tumor‐selective ROS amplification and antitumor immunity

VIEW, EarlyView.
Cancer cells are vulnerable to oxidative stress, yet exploit immune tolerance to escape destruction. In contrast, their metabolic profile is markedly altered to support rapid proliferation, accompanied by elevated production of reactive oxygen species (ROS).
Manuela Calin, Galyna Bila, Ileana Manduteanu, Rostyslav Bilyy   +3 more
wiley   +1 more source

Table_1_Causal effects of immune cell surface antigens and functional outcome after ischemic stroke: a Mendelian randomization study.xlsx

ObjectiveWhile observational studies link immune cells with post-stroke functional outcome, the underlying immune mechanisms are not well understood.
Guohua Yu (176526), Yize Cai (18173314), Keqi Wan (18173311), Zhen Feng (298259), Chafeng Zheng (12980275), Jiawei Gui (18173308), Weiming Sun (3488033), Lang Shuai (7515551), Xiangli Dong (7515548)   +8 more
core   +1 more source

A tandem CD19/CD20 CAR lentiviral vector drives on-target and off-target antigen modulation in leukemia cell lines

, 2017
Background Clinical success with chimeric antigen receptor (CAR)- based immunotherapy for leukemia has been accompanied by the associated finding that antigen-escape variants of the disease are responsible for relapse.
Ying Xiong, Waleed Haso, Rimas J. Orentas, Darong Wu, Andrew Kaiser, Dina Schneider, Boro Dropulic, Volker Nӧlle, Sarah Schmitz   +8 more
core   +1 more source

CD20 Antigen Status [PDF]

, 2020
openaire   +1 more source

Nanobodies as next‐generation targeting platforms: From discovery technologies to translational biomedicine

VIEW, EarlyView.
Nanobodies, derived from the variable domains of camelid heavy‐chain‐only antibodies, have emerged as transformative biomedical tools due to their nanoscale size, exceptional stability, and unique capacity to recognize cryptic epitopes. This review provides a comprehensive overview of the field, outlining the structural and biochemical features of ...
Zhenrui Ye, Xianyang Li, Meixiao Zhan
wiley   +1 more source