Results 81 to 90 of about 33,041 (261)
Gene expression signatures from single‐cell transcriptomics predict Sjögren's syndrome
iMetaOmics, EarlyView.A machine learning‐based 12‐gene signature (SjS.Sig) was developed from scRNA‐seq data of PBMCs from Sjögren's syndrome patients. The model was validated using bulk RNA‐seq datasets and further confirmed through flow cytometry and qPCR analysis in an independent clinical cohort, demonstrating robust diagnostic potential.
Shumin Cheng +20 more
wiley +1 more source
, 2023 Nucleic acid ligands called aptamers are single-stranded DNA or RNA molecules which fold into functional three-dimensional structures to facilitate their target binding with high affinity and specificity.
Williams, Nicole B
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Current Cell/Organoid and Animal Models for Primary Sclerosing Cholangitis
Portal Hypertension &Cirrhosis, EarlyView.Primary sclerosing cholangitis (PSC) is a chronic cholestatic liver disease with limited therapeutic options and a marked risk of progression to biliary fibrosis, cirrhosis, and malignancy. Progress in PSC research has been hindered by the lack of models that faithfully recapitulate the complex biliary microenvironment and disease heterogeneity ...
Qigu Yao +4 more
wiley +1 more source
ObjectiveWhile observational studies link immune cells with post-stroke functional outcome, the underlying immune mechanisms are not well understood.
Guohua Yu (176526) +8 more
core +1 more source
Rheumatology &Autoimmunity, EarlyView.Graphical abstract summarizing the multifactorial pathogenesis of rheumatoid arthritis (RA) and the therapeutic potential of mesenchymal stromal cell (MSC) therapy. MSCs provide promising benefits through their immunomodulatory properties, low immunogenicity, ability to promote tissue repair, and multi‐lineage differentiation, presenting a potential ...
Yingjia Chen +6 more
wiley +1 more source
ObjectiveWhile observational studies link immune cells with post-stroke functional outcome, the underlying immune mechanisms are not well understood.
Guohua Yu (176526) +8 more
core +1 more source
Anti-CD22/CD20 Bispecific antibody with enhanced trogocytosis for treatment of Lupus.
, 2014 The humanized anti-CD22 antibody, epratuzumab, has demonstrated therapeutic activity in clinical trials of lymphoma, leukemia and autoimmune diseases, treating currently over 1500 cases of non-Hodgkin lymphoma, acute lymphoblastic leukemias, Waldenström ...
Chien-Hsing Chang +5 more
core +1 more source
27‐color flow cytometry for measurable residual disease detection in B‐cell lymphoblastic leukemia
Cytometry Part B: Clinical Cytometry, EarlyView.
Ryan C. Shean +3 more
wiley +1 more source
Recent Advances in Photocatalyst‐Driven Protein Labeling and Proximity Mapping
The Chemical Record, EarlyView.Photocatalyst‐driven protein labeling and proximity mapping have rapidly advanced as powerful strategies for spatiotemporal control in complex biological environments. This review integrates recent developments across single‐electron transfer and energy transfer‐based mechanisms and highlights how catalyst design, reactive intermediates, and diffusion ...
Shinichi Sato +3 more
wiley +1 more source
CD20 positivity in classical Hodgkin′s lymphoma: Diagnostic challenge or targeting opportunity
, 2009 Background: It is now well established that Hodgkin cells are clonal B cells with a CD30 and CD15 phenotype. However, on immunohistochemistry, in our experience and the experience of others, CD20 positivity in an otherwise typical classical Hodgkin ...
Pervez Shahid, Barakzai Muhammad
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