Results 81 to 90 of about 231,458 (256)

Establishment of pediatric reference ranges for circulating naïve and memory T and B cell subsets guided by the human immunophenotyping consortium standardization initiative: A large, single center U.S. experience

Cytometry Part B: Clinical Cytometry, EarlyView.
Abstract Our knowledge of the immune system continues to expand at a rapid pace, and this coupled with technological advances now enables us to interrogate both the breadth and the depth of the immune response at levels without precedent. This has also facilitated rapidly integrating some of this carefully vetted knowledge into clinical practice ...
Aaruni Khanolkar, Aisha Ahmed
wiley   +1 more source

Immunotherapy for B-Cell Neoplasms using T Cells expressing Chimeric Antigen Receptors : From antigen choice to clinical implementation

Sultan Qaboos University Medical Journal, 2012
Immunotherapy with T cells expressing chimeric antigen receptors (CAR) is being evaluated as a potential treatment for B-cell neoplasms. In recent clinical trials it has shown promising results.
Mohamed-Rachid Boulasse, Ahmed Galal
doaj  

Analysis of transplant rejection in rabbits aponeurosis [PDF]

Einstein (São Paulo), 2012
Objective: To study the feasibility of heterologous aponeurosisto close the abdominal wall of rabbits emphasizing the rejectionprocess. Methods: This project was approved by the Animals CareCommittee of the Faculdade de Ciências Médicas da Santa Casa ...
Andre Ibrahim David, Eduardo Sauerbronn Gouvea, Felipe Ribeiro Batista, Paulo Henrique Fogaça de Barros, Dino Martini Filho, Victor Arias, Paulo Roberto Corsi, Luiz Arnaldo Szutan   +7 more
doaj  

Predicting the efficacy of anti-B-cell therapy in patients with multiple sclerosis [PDF]

Анналы клинической и экспериментальной неврологии
Introduction. Prognostic markers can be used to evaluate a response to anti-B-cell therapy in patients with multiple sclerosis (MS). Aim. The study aimed to evaluate the characteristics of peripheral blood (PB) lymphocytes and monocytes in patients ...
Yuliana A. Belova, Yulia Yu. Chuksina, Sergey V. Kotov   +2 more
doaj   +1 more source

A Bispecific Antibody-IFNα2b Immunocytokine Targeting CD20 and HLA-DR Is Highly Toxic to Human Lymphoma and Multiple Myeloma Cells

, 2010
The short circulating half-life and side effects of IFNα affect its dosing schedule and efficacy. Fusion of IFNα to a tumor-targeting monoclonal antibody (MAb-IFNα) can enhance potency due to increased tumor localization and improved pharmacokinetics. We
Rhona Stein, Chien-Hsing Chang, David M. Goldenberg, Diane L. Rossi, Edmund A. Rossi   +4 more
core   +1 more source

Challenges and Pitfalls to Diagnosing NUTM1‐Rearranged Neoplasia of the Pancreas by Cytology and Ancillary Studies

Diagnostic Cytopathology, EarlyView.
ABSTRACT Fine‐needle aspiration cytology specimens are frequently utilized for ancillary studies to identify diagnostic and prognostic information. This case highlights diagnostic pitfalls and challenges in diagnosing NUTM1‐rearranged neoplasia on pancreatic cytology.
Terrance J. Lynn
wiley   +1 more source

Presence of T cells directed against CD20-derived peptides in healthy individuals and lymphoma patients

, 2019
International audiencePreclinical and clinical studies have suggested that cancer treatment with antitumor antibodies induces a specific adaptive T cell response. A central role in this process has been attributed to CD4+ T cells, but the relevant T cell
Josseaume, Nathalie, Toubert, Antoine, Milcent, Benoit, Couture, Alexandre, Riller, Quentin, Teillaud, Jean-Luc, Amorim, Sandy, Sibéril, Sophie, Latouche, Jean-Baptiste, Thieblemont, Catherine, Rabia, Emilia, Loiseau, Pascale, Giglioli, Ilenia, Deligne, Claire, Toutirais, Olivier, Jeger-Madiot, Raphaël, Hamieh, Mohamad, Brice, Pauline, Graff-Dubois, Stéphanie, Lone, Yu-Chun   +19 more
core   +1 more source

Next‐Generation CAR‐T Cell Therapy: From Modular Design to Clinical Expansion

Exploration, EarlyView.
Over the past decades, chimeric antigen receptor (CAR)‐T cell therapy has evolved from a linear engineering concept into a powerful yet constrained immunotherapy, limited by tumour microenvironment barriers, immune evasion, and manufacturing complexity.
Yuesong Bai, Jintao Qin, Zongjun Dai, Ran Yan, Yong Yang, Wenguang Wang   +5 more
wiley   +1 more source

FOXO1 promotes resistance of non-Hodgkin lymphomas to anti-CD20-based therapy

, 2020
Diminished overall survival rate of non-Hodgkin lymphoma (NHL) patients treated with a combination regimen of rituximab, cyclophosphamide, doxorubicin, vincristine and prednisone (R-CHOP) has been recently linked to recurrent somatic mutations activating
Jakub Golab (88443), Dinis Calado (3744883), Michal Dwojak (9342560), Marcin M Machnicki (9342575), Abdessamad Zerrouqi (31596), Giulia Morlino (8848979), Malgorzata Bobrowicz (9342569), Dimitar G Efremov (9342587), Stefania Gobessi (9342578), Marta Siernicka (9342572), Magdalena Winiarska (88418), Nina Miazek (9342566), Piotr Zapala (9342563), Agnieszka Zagozdzon (4761018), Przemyslaw Juszczynski (9342590), Joanna Barankiewicz (9342581), Ewa Lech-Maranda (9342584), Beata Pyrzynska (9342557), Kamil Bojarczuk (3072240)   +18 more
core  

Reversal of Chronic Stress‐Induced Inflammaging by Bazi Bushen Formula Through AMPK‐Sirtuins Axis Activation and Myeloid Reset

Exploration, EarlyView.
Chronic stressors trigger systemic immune remodeling marked by myeloid expansion and lymphoid suppression, and this immune imbalance subsequently drives tissue pathology through proinflammatory signaling and senescence amplification, with the lung and kidney confirmed as the most vulnerable target organs.
Mengnan Li, Zheming Chen, Lu Wang, Zixuan Wang, Shixiong Zhang, Kunxu Niu, Xiaogang Shen, Xuan Lu, Runtao Zhang, Yuning Jiang, Yawen Li, Yi Dai, Xiyang Tang, Bin Hou, Min Shi, Xiaoya Wang, Zhifang Guo, Xingyu Xing, Ning Kang, Hongrong Li, Tianyu Kang, Evelyne Bischof, Yunlong Hou, Zhenhua Jia   +23 more
wiley   +1 more source