Results 61 to 70 of about 33,041 (261)

Causal effects of immune cell surface antigens and functional outcome after ischemic stroke: a Mendelian randomization study [PDF]

ObjectiveWhile observational studies link immune cells with post-stroke functional outcome, the underlying immune mechanisms are not well understood.
Jiawei Gui, Yize Cai, Guohua Yu, Chafeng Zheng, Zhen Feng, Xiangli Dong, Lang Shuai, Weiming Sun, Keqi Wan   +8 more
core   +1 more source

Potassium/sodium cation carriers robustly up-regulate CD20 antigen by targeting MYC, and synergize with anti-CD20 immunotherapies to eliminate malignant B cells

Haematologica
Our investigation uncovers that nanomolar concentrations of salinomycin, monensin, nigericin, and narasin (a group of potassium/sodium cation carriers) robustly enhance surface expression of CD20 antigen in B-cell-derived tumor cells, including primary malignant cells of chronic lymphocytic leukemia and diffuse large B-cell lymphoma.
Toruń, Anna, Zdanowicz, Aleksandra, Nina Miązek-Zapała, Piotr Zapała, Pradhan, Bhaskar, Jędrzejczyk, Marta, Andrzej Ciechanowicz, Zofia Pilch, Marcin Skórzyński, Słabicki, Mikołaj, Rymkiewicz, Grzegorz, Barankiewicz, Joanna, Martines, Claudio, Laurenti, Luca, Marta Katarzyna Struga, Magdalena Winiarska, Jakub Adam Gołąb, Magdalena Kucia, Mariusz Ratajczak, Huczyński, Adam, Calado, Dinis, Efremov, Dimitar, Abdessamad Zerrouqi, Beata Pyrzyńska   +23 more
openaire   +3 more sources

Expert Perspectives: Defining and managing progressive pulmonary fibrosis in systemic sclerosis

Arthritis &Rheumatology, Accepted Article.
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Devis Benfaremo, Dinesh Khanna, Corrado Campochiaro, Vincent Cottin, Fabrizio Luppi, Marco Matucci‐Cerinic, Gianluca Moroncini, Yannick Allanore   +7 more
wiley   +1 more source

Nanomaterial‐based immune therapeutic strategies in neurodegenerative diseases

BMEMat, EarlyView.
This review highlights the immunomodulatory potential of nanomaterials (NMs) in treating neurodegenerative diseases (NDs). It focuses on their roles in regulating innate and adaptive immune responses to maintain immune homeostasis. By providing insights into these mechanisms, the review lays the groundwork for innovative NMs therapeutic strategies to ...
Xinru Zhou, Jia Liu, Shulin Lai, Suhan Yin, Bingmin Luo, Longquan Shao, Yiyuan Kang   +6 more
wiley   +1 more source

Living Microbial Drugs

Chemistry – A European Journal, EarlyView.
The introduction outlines the review scope. Microbial cell factories as living drugs cover host–gut microbiota, bacteria, yeast, and other microbial systems, with comparative host advantages. Engineering strategies include synthetic circuits, quorum sensing, and memory.
Cemile Elif Özçelik, Nazlıcan Tunç, Senem Şen, Urartu Özgür Şafak Şeker   +3 more
wiley   +1 more source

From Inflammatory Bowel Disease to Cancer: Gut Microbiota–Immune Microenvironment Crosstalk and Natural Product‐Based Therapeutic Opportunities

Cancer Nexus, EarlyView.
ABSTRACT Inflammatory bowel disease (IBD), primarily Crohn's disease and ulcerative colitis, is a chronic relapsing inflammatory disorder of the gastrointestinal tract and an important risk factor for IBD‐associated cancer. Increasing evidence suggests that gut microbiota dysbiosis, epithelial barrier dysfunction, and immune microenvironment remodeling
Xue Zhang, Chongchong Gao, Rui Jiang, Zijian Wu, Jian Bai   +4 more
wiley   +1 more source

Identification of T:B Cell Multimers After Bispecific T Cell Engagement, Using Both Conventional and Imaging Flow Cytometry

Cytometry Part A, EarlyView.
ABSTRACT Bispecific T cell engagers bring together T cells with malignant B cell targets to enable synapse formation and disease eradication of hematological malignancies. The proportion of T cells and their ability to bind to their targets varies between patients and may be a biomarker of response.
Joanne E. Davis, Mandy Ludford‐Menting, Helena Peng, Darryl N. Johnson, David S. Ritchie, Rachel Koldej   +5 more
wiley   +1 more source

Flow cytometric study of potential target antigens (CD19, CD20, CD22, CD33) for antibody-based immunotherapy in acute lymphoblastic leukemia: analysis of 552 cases

, 2011
Monoclonal antibody (MoAb)-based therapies have opened innovative treatment avenues that have impacted on the management of patients with both neoplastic and non-neoplastic hematological diseases. The aim of our study was to evaluate in a large series of
Omar Perbellini, Maria Laura Milani, Giovanni Pizzolo, Laura M. Milani, Sara Raponi, Anna Guarini, Stefania Intoppa, RAPONI, SARA, FOA, Roberto, Antonella Vitale, Maria Stefania De Propris, Robin Foá, Loredana Elia, GUARINI, Anna   +13 more
core   +2 more sources

Flow cytometry‐based monitoring of chimeric antigen receptor (CAR) T cells: Reagent selection, assay design, and clinical utility

Cytometry Part B: Clinical Cytometry, EarlyView.
Abstract Accurate quantification of chimeric antigen receptor (CAR) T cells is essential for monitoring post‐infusion CART expansion and persistence and for real‐time clinical decision‐making. Multiparameter flow cytometry (MFC) enables rapid, live‐cell detection with absolute quantification and concurrent immunophenotypic characterization. This review
Jianhua Ling, Wei Wang, Sa A. Wang
wiley   +1 more source

Selection of an Anti-CD20, Single-Chain Antibody by Phage ELISA on Fixed Cells

, 1999
Cloning the correct genes that code for antibody-variable domains from hybridomas is often complicated by the presence of several immunoglobulin transcripts, some of them arising from a myeloma cell line.
Michael Braunagel, Timo Kürschner, Stefanie Schmidt, Melvyn Little   +3 more
core   +1 more source