Results 141 to 150 of about 33,041 (261)

CAR‐T Cells in Ulcerative Colitis: The Renaissance of B‐Cell Targeted Therapy in UC

JCC Plus, Volume 1, Issue 4, July 2026.
ABSTRACT A recent New England Journal of Medicine report described the first successful use of anti‐CD19 CAR‐T cell therapy in a patient with multirefractory ulcerative colitis (UC). This exceptional case provides striking proof of concept that B cells and plasma cells can act as key pathogenic drivers in UC.
Zlata Chkolnaia, Mathieu Uzzan, Walter Reinisch   +2 more
wiley   +1 more source

Integrating Flow Cytometry in the Diagnostic Work of HIV-Associated Hodgkin's Lymphomas. [PDF]

J Cell Mol Med
Santa M, Cenariu D, Tigu AB, Damian M, Rantshabeng P, Gaolathe T, Ndlovu AK, Abdelrahman K, Nistor M, Kegyes D, Gulei D, Jinca C, Bancos A, Rus I, Bumbea H, Tomacinschii V, Buruiana S, Bilal R, Selicean C, Zdrenghea M, Fetica B, Stefan C, Fromm J, Tomuleasa C.   +23 more
europepmc   +1 more source

Impact of Genomic Mutations on the Transcriptional Pathways and Tumor Microenvironment Landscape of Localized Early Prostate Cancer

The Prostate, Volume 86, Issue 10, Page 1103-1114, July 2026.
ABSTRACT Background The management of intermediate‐risk early prostate cancer (PCa) is challenging due to the difficulty in distinguishing indolent from aggressive tumors. This study explores the association between genomic alterations and the tumor and its microenvironment (TME) and implications for disease progression. Methods We performed multi‐omic
William Lautert‐Dutra, Camila M. Melo, Luiz P. Chaves, Francisco C. Souza, Vida Talebian, Cheryl Crozier, Mary Anne Quintayo, Linda Liao, Dan Dion, Fabiano P. Saggioro, Felipe S. Avante, Rodolfo B. dos Reis, Jeremy A. Squire, Jane Bayani   +13 more
wiley   +1 more source

Experimental Therapies in Multiple Sclerosis: Epstein-Barr Virus and Potential EBV-Related Therapeutic Strategies-A Systematic Review. [PDF]

J Clin Med
Bartczak J, Gronowski P, Małek M, Denkiewicz A, Grodzka O, Chądzyński P, Domitrz I.   +6 more
europepmc   +1 more source

ADDENDUM: T Cells Expressing CD19/CD20 Bispecific Chimeric Antigen Receptors Prevent Antigen Escape by Malignant B Cells [PDF]

Cancer Immunology Research, 2016
Eugenia, Zah, Meng-Yin, Lin, Anne, Silva-Benedict, Michael C, Jensen, Yvonne Y, Chen   +4 more
openaire   +2 more sources

Ph‐Negative Acute Lymphoblastic Leukemia in the Older Adults: Biology, Therapeutic Strategies and Unmet Needs

European Journal of Haematology, Volume 117, Issue 1, Page 24-41, July 2026.
ABSTRACT Acute lymphoblastic leukaemia (ALL) in older adults represents a growing clinical challenge, driven by an ageing population, adverse disease biology, and reduced tolerance to intensive chemotherapy. Although pediatric‐inspired regimens have improved outcomes in younger adults with Philadelphia chromosome (Ph)‐negative ALL, survival in older ...
Antonella Bruzzese, Ernesto Vigna, Enrica Antonia Martino, Santino Caserta, Francesco Mendicino, Maria Eugenia Alvaro, Caterina Labanca, Eugenio Lucia, Virginia Olivito, Marco Fiorillo, Nicola Amodio, Fortunato Morabito, Massimo Gentile   +12 more
wiley   +1 more source

Chimeric Antigen Receptor T-Cell Revolution Remodeling Immunity to Conquer Autoimmune Disease. [PDF]

Research (Wash D C)
Shao W, Liu J, Sun M, Yu D.
europepmc   +1 more source

Loncastuximab Tesirine in Relapsed/Refractory Diffuse Large B‐Cell Lymphoma: Evidence and Practical Guidance From Italian Clinical Experience

European Journal of Haematology, Volume 117, Issue 1, Page 144-153, July 2026.
ABSTRACT Patients with relapsed/refractory (R/R) diffuse large B‐cell lymphoma (DLBCL) who progress to the third‐line setting face a lack of standardized treatment, despite the presence of multiple available therapies. In this context, antibody–drug conjugates represent a relatively new class of anticancer agents; among them, loncastuximab tesirine is ...
Francesca Bonello, Andrea Aroldi, Alessia Castellino, Lara Mannelli, Elia Boccellato, Serena Rosati, Luisa Verga, Umberto Vitolo   +7 more
wiley   +1 more source

Beyond Hematology-Current Insights into Chimeric Antigen Receptor (CAR) T-Cell Therapy for Skin and Connective Tissue Disorders. [PDF]

Cells
Ciosek A, Hofmann J, Galant K, Marinkovich MP, Wierzbowska A, Ciążyńska M, Bień N, Narbutt J, Lesiak A.   +8 more
europepmc   +1 more source

Stage‐Dependent Transcriptional Reprogramming of B‐Cell Receptor Signaling and Antigen Presentation During Bovine Leukemia Virus–Driven Lymphomagenesis

Animal Genetics, Volume 57, Issue 3, June 2026.
ABSTRACT Bovine leukemia virus (BLV), an oncogenic deltaretrovirus, establishes lifelong infection in cattle and induces enzootic bovine leukosis in a subset of animals following prolonged latency. Despite extensive evidence of immune dysregulation, stage‐specific transcriptional reprogramming of B cells, the primary viral reservoir remains ...
Mohammad Mehdi Akbarin, Zahra Farjami, Cecilia Rodríguez Murillo, Víctor David González‐Fernández, Gabriel Eduardo Acevedo‐Jiménez, Lucero de María Ávila‐De la Vega, Hugo Ramírez Álvarez   +6 more
wiley   +1 more source