Rituximab-Induced Serum Sickness in Patients With Multiple Sclerosis: A Case Report and Literature Review. [PDF]
Sikkal A +4 more
europepmc +1 more source
Pretargeted Anti-CD20 Radioimmunotherapy with scFv Fusion Protein Safely Combines with BEAM and ASCT in Patients with High-risk B-cell Lymphomas. [PDF]
Orozco JJ +10 more
europepmc +1 more source
B-cell-driven relapse and anti-CD20 rescue therapy after Alemtuzumab in RRMS: case report and literature review. [PDF]
Bruno PA +6 more
europepmc +1 more source
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Ofatumumab and Granzyme B as immunotoxin against CD20 antigen
In Silico Pharmacology, 2022Anti-CD20 antibodies such as ofatumumab has demonstrated efficacy in relapsed/refractory chronic lymphocytic leukemia, are among the most successful therapies to date. In this study, we have designed an immunotoxin composed of Granzyme B and the high affinity variant of Ofatumumab.
Fateme Sefid +6 more
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CD20 is a potential target for immunotherapy treatments of haematological malignancies due to its specific expression and unique biological property. Over the years, many anti-CD20 monoclonal antibodies (mAbs) have been developed, such as Rituximab, Ibritumomab, Tositumomab, etc., and applied in B cells related to cancer treatments.
Nguyen Thanh Thao Vo +4 more
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Development of a Mimotope-Based Vaccine Against CD20 Antigen
Protein & Peptide Letters, 2007CD20, a B-cell-specific protein, is a primary target for immunotherapy of B-cell lymphomas. We used a mimotopes of CD20 to construct vaccines for B-cell-related disorders. The immunogenicity of the vaccines was tested in BALB/c mice. Results of this study suggest that the mimotope may be a useful tool for the construction of a functional vaccine to ...
Meng, Li +5 more
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CD20: A target antigen for immunotherapy of autoimmune diseases
Autoimmunity Reviews, 2005This article reviews the role of CD20 antigen in B cell function and the effectiveness and limits of passive immunotherapy with anti-CD20 monoclonal antibody (Rituximab) in the treatment of autoimmune (or immune-mediated) diseases. Active immunotherapy is a more feasible way to control these chronic diseases.
PEROSA, Federico +4 more
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Radiobiology of radioimmunotherapy: Targeting CD20 B-cell antigen in non-Hodgkin's lymphoma
International Journal of Radiation Oncology*Biology*Physics, 2004The radiobiology of radioimmunotherapy is an important determinant of both the toxicity and the efficacy associated with the treatment of B-cell non-Hodgkin's lymphoma with radiolabeled anti-CD20 monoclonal antibodies. The properties of the target, CD20, and the mechanisms of action of both the monoclonal antibodies and the associated exponentially ...
M Carmen, Hernandez, Susan J, Knox
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Immunological evaluation of predicted linear B‐cell epitopes of human CD20 antigen
Biotechnology and Applied Biochemistry, 2012AbstractThe importance of B‐lymphocyte‐restricted differentiation antigen Bp35 (CD20) as a target for immunotherapeutic depletion of B cells is irrefutable. Several anti‐human CD20 (anti‐hCD20) monoclonal antibodies are expressed at different stages of development.
Mahdi Habibi, Anbouhi +8 more
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Analysis of cis-acting elements present in the CD20/B1 antigen promoter
The Journal of Immunology, 1991Abstract A genomic clone spanning a large portion of the 5’ untranscribed region of the CD20 gene was isolated. Deletion analysis of subcloned fragments identified several regulatory elements. A major positive cis-acting element was localized between base pairs -290/-186.
P, Rieckmann +4 more
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