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Clonal expression of differentiation and Ia‐like antigens on alloreactive human T lymphocytes
European Journal of Immunology, 1984AbstractA series of human T lymphocyte clones showing specific responses for major histocompatibility complex‐encoded alloantigens were isolated from a single culture. They were classified into distinct functional groups based on measurement of alloantigen‐specific proliferation and cytotoxicity.
D J, Schendel +3 more
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INDUCTION OF HUMAN T-LYMPHOCYTE DIFFERENTIATION ANTIGENS
1976Publisher Summary This chapter presents a summarization of the results of an analysis of human T-lymphocyte differentiation antigens (HTLAs) demonstrating the existence of human T-lymphocyte differentiation antigens, their induction on precursor cells by thymic factors, and the application of this methodology to the investigation of immunodeficiency ...
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Leukemia Research, 1986
There are clones of myeloid leukemic cells that can be induced to differentiate in vitro and in vivo by normal macrophage and granulocyte differentiation-inducing protein MGI-2 (= DF). The differentiation of these myeloid leukemic cells in vivo is regulated by a cell mediated immune response which requires T lymphocytes.
J, Lotem, A, Ben-Nun, L, Sachs
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There are clones of myeloid leukemic cells that can be induced to differentiate in vitro and in vivo by normal macrophage and granulocyte differentiation-inducing protein MGI-2 (= DF). The differentiation of these myeloid leukemic cells in vivo is regulated by a cell mediated immune response which requires T lymphocytes.
J, Lotem, A, Ben-Nun, L, Sachs
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T-lymphocyte differentiation is accompanied by increase in sialic acid content of Thy-1 antigen
Nature, 1980Lymphocyte differentiation is accompanied by changes in the expression of various glycoproteins at the cell surface 1–4. Whether changes in the structures of individual glycoproteins, as opposed to changes in then expression, also occur during this differentiation is not known.
Hoessli, D, Bron, C, Pink, J R
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Exogenous and endogenous antigens are differentially presented by mast cells to CD4+ T lymphocytes
European Journal of Immunology, 1996AbstractIn the present work, we explored the cytokine‐dependent regulation of bone marrow‐derived mast cell (BMMC) antigen‐presenting cell (APC) function, and co‐stimulation requirements, and analyzed the nature of antigens presented to T cells. We observed an up‐regulation of the APC function of mast cells induced by granulocyte/macrophage‐colony ...
P, Frandji +5 more
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[Antigen recognition and differentiation of T lymphocytes].
Hematology and cell therapy, 1998During their intrathymic development, T lymphocytes acquire the ability to recognize myriads of antigens bound to self major histocompatibility molecules. This property is linked to the activation at early stages of thymic development of the biosynthesis of the antigen recognition receptors, the T cell receptors.
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Differentiation antigens expressed predominantly on CD4− CD8− T lymphocytes (WC1, WC2)
Veterinary Immunology and Immunopathology, 1991Abstract The 14 mAbs representing workshop cluster 1 recognise a 215 300 kDa antigen expressed on a subpopulation of lymphocytes which express low levels of CD5 but are negative for other B and T cell markers defined by workshop antibodies. Separate studies with cDNA probes for bovine CD3 and T cell receptor indicate that these lymphocytes ...
W.I. Morrison, W.C. Davis
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Differential Ras signaling via the antigen receptor and IL-2 receptor in primary T lymphocytes
Biochemical and Biophysical Research Communications, 2003Ras can become activated via multiple distinct receptors in T lymphocytes. However, mechanistic studies of Ras signaling in normal T cells have been hampered by the lack of an efficient technology for gene transfer into resting post-thymic cells. We have overcome this limitation by utilizing adenoviral transduction of T cells from Coxsackie/adenovirus ...
Marks, Reinhard +5 more
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The Journal of Immunology, 1991
Abstract Alloreactive CTL raised against HLA-A2 Ag often display heterogeneous recognition of HLA-A2+ target cells. This heterogeneity has been found to reflect structural polymorphism among the corresponding target Ag, thus defining HLA-A2 subtypes. A previous study (van der Poel et al. 1986. Human Immunol.
A R, Castaño +3 more
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Abstract Alloreactive CTL raised against HLA-A2 Ag often display heterogeneous recognition of HLA-A2+ target cells. This heterogeneity has been found to reflect structural polymorphism among the corresponding target Ag, thus defining HLA-A2 subtypes. A previous study (van der Poel et al. 1986. Human Immunol.
A R, Castaño +3 more
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Immunology, 1983
The results presented in this paper demonstrate that a mouse IgM monoclonal antibody (T-80) recognizes an antigen on cells of the T-lymphocyte lineage of sheep. However, this antibody does not identify all T cells, as 10-20% of thymocytes and some peripheral-blood T cells are negative. T-80- thymocytes reside in the medulla.
M, Miyasaka +6 more
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The results presented in this paper demonstrate that a mouse IgM monoclonal antibody (T-80) recognizes an antigen on cells of the T-lymphocyte lineage of sheep. However, this antibody does not identify all T cells, as 10-20% of thymocytes and some peripheral-blood T cells are negative. T-80- thymocytes reside in the medulla.
M, Miyasaka +6 more
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