Results 21 to 30 of about 1,437,318 (308)
Review of current and future therapeutics in ABPA
Therapeutic Advances in Chronic Disease, 2021 Allergic bronchopulmonary aspergillosis is an allergic pulmonary condition caused by hypersensitivity to antigens of Aspergillus sp. found most commonly in patients with underlying asthma or cystic fibrosis.
Elisa Lewington-Gower +2 more
doaj +1 more source
Signalling C-Type Lectins in Antimicrobial Immunity [PDF]
, 2013 Funding: This work was funded by the Wellcome Trust, Medical Research Council and the University of Aberdeen. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.Peer ...
Brown, Gordon D., Drummond, Rebecca A.
core +11 more sources
Functional Characterization of Hexacorallia Phagocytic Cells
Frontiers in Immunology, 2021 Phagocytosis is the cellular defense mechanism used to eliminate antigens derived from dysregulated or damaged cells, and microbial pathogens. Phagocytosis is therefore a pillar of innate immunity, whereby foreign particles are engulfed and degraded in ...
Grace A. Snyder +9 more
doaj +1 more source
Discriminating antigen and non-antigen using proteome dissimilarity II: viral and fungal antigens [PDF]
Bioinformation, 2010 Immunogenicity arises via many synergistic mechanisms, yet the overall dissimilarity of pathogenic proteins versus the host proteome has been proposed as a key arbiter. We have previously explored this concept in relation to Bacterial antigens; here we extend our analysis to antigens of viral and fungal origin.
Ramakrishnan, Kamna, Flower, Darren R
openaire +3 more sources
Germline IgM predicts T cell immunity to Pneumocystis
JCI Insight, 2022 Pneumocystis is the most common fungal pulmonary infection in children under the age of 5 years. In children with primary immunodeficiency, Pneumocystis often presents at 3–6 months of age, a time period that coincides with the nadir of maternal IgG and ...
Kristin Noell +6 more
doaj +1 more source
Novel Pneumocystis Antigen Discovery Using Fungal Surface Proteomics [PDF]
Infection and Immunity, 2014 ABSTRACT Pneumonia due to the fungus Pneumocystis jirovecii is a life-threatening infection that occurs in immunocompromised patients. The inability to culture the organism as well as the lack of an annotated genome has hindered antigen discovery that could be useful in developing novel vaccine- or ...
Mingquan, Zheng +4 more
openaire +3 more sources
Frontiers in Immunology, 2021 Cryptococcus neoformans, an opportunistic fungal pathogen ubiquitously present in the environment, causes cryptococcal meningitis (CM) mainly in immunocompromised patients, such as AIDS patients.
A. Elisabeth Gressler +11 more
doaj +1 more source
Allergic bronchopulmonary aspergillosis: diagnostic and treatment challenges [PDF]
, 2016 Allergic bronchopulmonary aspergillosis (ABPA) is a pulmonary disorder, occurring mostly in asthmatic and cystic fibrosis patients, caused by an abnormal T-helper 2 lymphocyte response of the host to Aspergillus fumigatus antigens.
CINICOLA, BIANCA LAURA +3 more
core +1 more source
Therapies and Vaccines Based on Nanoparticles for the Treatment of Systemic Fungal Infections
Frontiers in Cellular and Infection Microbiology, 2020 Treatment modalities for systemic mycoses are still limited. Currently, the main antifungal 18 therapeutics include polyenes, azoles, and echinocandins. However, even in the setting of 19 appropriate administration of antifungals, mortality rates remain ...
Brenda Kischkel +5 more
semanticscholar +1 more source
Aspergillus fumigatus preexposure worsens pathology and improves control of Mycobacterium abscessus pulmonary infection in mice [PDF]
, 2018 Cystic fibrosis (CF) is an autosomal recessive disease caused by mutations in the CF transmembrane conductance regulator (CFTR) gene. Mutations in this chloride channel lead to mucus accumulation, subsequent recurrent pulmonary infections, and ...
Elsegeiny, Waleed +7 more
core +2 more sources