Functional Characterization of Hexacorallia Phagocytic Cells
Frontiers in Immunology, 2021 Phagocytosis is the cellular defense mechanism used to eliminate antigens derived from dysregulated or damaged cells, and microbial pathogens. Phagocytosis is therefore a pillar of innate immunity, whereby foreign particles are engulfed and degraded in ...
Grace A. Snyder +9 more
doaj +1 more source
Cooperative Stimulation of Dendritic Cells by Cryptococcus neoformans Mannoproteins and CpG Oligodeoxynucleotides [PDF]
, 2008 While mannosylation targets antigens to mannose receptors on dendritic cells (DC), the resultant immune response is suboptimal. We hypothesized that the addition of toll-like receptor (TLR) ligands would enhance the DC response to mannosylated antigens ...
Dan, Jennifer M. +3 more
core +9 more sources
Germline IgM predicts T cell immunity to Pneumocystis
JCI Insight, 2022 Pneumocystis is the most common fungal pulmonary infection in children under the age of 5 years. In children with primary immunodeficiency, Pneumocystis often presents at 3–6 months of age, a time period that coincides with the nadir of maternal IgG and ...
Kristin Noell +6 more
doaj +1 more source
Discriminating antigen and non-antigen using proteome dissimilarity II: viral and fungal antigens [PDF]
Bioinformation, 2010 Immunogenicity arises via many synergistic mechanisms, yet the overall dissimilarity of pathogenic proteins versus the host proteome has been proposed as a key arbiter. We have previously explored this concept in relation to Bacterial antigens; here we extend our analysis to antigens of viral and fungal origin.
Darren R. Flower, Kamna Ramakrishnan
openaire +4 more sources
From phagocytosis to metaforosis: calcineurin's deadly role in innate processing of fungi [PDF]
, 2018 Funding: This work was funded by the Wellcome Trust, Medical Research Council and the University of Aberdeen. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.Peer ...
Armstrong-James, D +3 more
core +6 more sources
Frontiers in Immunology, 2021 Cryptococcus neoformans, an opportunistic fungal pathogen ubiquitously present in the environment, causes cryptococcal meningitis (CM) mainly in immunocompromised patients, such as AIDS patients.
A. Elisabeth Gressler +11 more
doaj +1 more source
Immunotherapy of invasive fungal infection in hematopoietic stem cell transplant recipients [PDF]
, 2013 Despite the availability of new antifungal compounds, invasive fungal infection remains a significant cause of morbidity and mortality in children and adults undergoing allogeneic hematopoietic stem cell transplantation (HSCT). Allogeneic HSCT recipients
Klingebiel, Thomas +3 more
core +2 more sources
Allergic bronchopulmonary aspergillosis: diagnostic and treatment challenges [PDF]
, 2016 Allergic bronchopulmonary aspergillosis (ABPA) is a pulmonary disorder, occurring mostly in asthmatic and cystic fibrosis patients, caused by an abnormal T-helper 2 lymphocyte response of the host to Aspergillus fumigatus antigens.
CINICOLA, BIANCA LAURA +3 more
core +1 more source
Therapies and Vaccines Based on Nanoparticles for the Treatment of Systemic Fungal Infections
Frontiers in Cellular and Infection Microbiology, 2020 Treatment modalities for systemic mycoses are still limited. Currently, the main antifungal 18 therapeutics include polyenes, azoles, and echinocandins. However, even in the setting of 19 appropriate administration of antifungals, mortality rates remain ...
Brenda Kischkel +5 more
semanticscholar +1 more source
Lateral Flow Assays for the Diagnosis of Invasive Aspergillosis: Current Status. [PDF]
, 2017 Purpose of reviewDiagnosis during early stages of invasive aspergillosis (IA) and targeted antifungal treatment has the potential to improve survival significantly.
Heldt, Sven, Hoenigl, Martin
core +1 more source