Results 31 to 40 of about 20,381 (227)

Does treatment of intestinal helminth infections influence malaria? Background and methodology of a longitudinal study of clinical, parasitological and immunological parameters in Nangapanda, Flores, Indonesia (ImmunoSPIN Study)

BMC Infectious Diseases, 2010
Background Given that helminth infections are thought to have strong immunomodulatory activity, the question whether helminth infections might affect responses to malaria antigens needs to be addressed.
Sutanto Inge, Wahyuni Sitti, Djuardi Yenny, Wibowo Heri, Uh Hae, Ariawan Iwan, Lell Bertrand, Wammes Linda J, Hamid Firdaus, Prasetyani Margaretta A, Wiria Aprilianto E, May Linda, Luty Adrian JF, Verweij Jaco J, Sartono Erliyani, Yazdanbakhsh Maria, Supali Taniawati   +16 more
doaj   +1 more source

Impact of Helminth Infections during Pregnancy on Vaccine Immunogenicity in Gabonese Infants

Vaccines, 2020
Helminth infections are common in sub-Saharan Africa. Besides direct clinical effects, a bias towards a T helper type 2 (Th2) cell immune response is observed.
Judith Flügge, Ayôla Akim Adegnika, Yabo Josiane Honkpehedji, Thaisa L. Sandri, Esther Askani, Gédéon Prince Manouana, Marguerite Massinga Loembe, Sina Brückner, Mohamed Duali, Johannes Strunk, Benjamin Mordmüller, Selidji Todagbe Agnandji, Bertrand Lell, Peter G. Kremsner, Meral Esen   +14 more
doaj   +1 more source

Helminth infections coincident with active pulmonary tuberculosis inhibit mono- and multifunctional CD4+ and CD8+ T cell responses in a process dependent on IL-10. [PDF]

PLoS Pathogens, 2014
Tissue invasive helminth infections and tuberculosis (TB) are co-endemic in many parts of the world and can trigger immune responses that might antagonize each other.
Parakkal Jovvian George, Rajamanickam Anuradha, Nathella Pavan Kumar, Rathinam Sridhar, Vaithilingam V Banurekha, Thomas B Nutman, Subash Babu   +6 more
doaj   +1 more source

Helminth parasites and immune regulation [version 1; referees: 2 approved]

F1000Research, 2018
Helminth parasites are complex metazoans that belong to different taxonomic families but that collectively share the capacity to downregulate the host immune response directed toward themselves (parasite-specific immunoregulation).
Pedro H. Gazzinelli-Guimaraes, Thomas B. Nutman   +1 more
doaj   +1 more source

Gr1+IL-4-producing innate cells are induced in response to Th2 stimuli and suppress Th1-dependent antibody responses [PDF]

, 2008
Alum is used as a vaccine adjuvant and induces T_h2 responses and T_h2-driven antibody isotype production against co-injected antigens.
A. S. McKee, Alving, Atochina, Beutler, Bomford, Brewer, Brewer, Brogdon, Cambier, Crawford, Cunningham, F. Crawford, Gavin, Grun, Grzych, Hoebe, J. W. Kappler, J. White, Jordan, Kaisho, Kane, Kapsenberg, Kawai, Lang, Layland, Li, Liu, M. MacLeod, MacDonald, McDonald, Medzhitov, Mohrs, Morefield, Noben-Trauth, Okano, Ouyang, P. Marrack, Pearce, Pollock, Reese, Schnare, Sokolovska, Steinman, Sun, Trinchieri, Whelan   +45 more
core   +1 more source

Does helminth activation of Toll-Like Receptors modulate immune response in Multiple Sclerosis patients?

Frontiers in Cellular and Infection Microbiology, 2012
Multiple sclerosis (MS) is an inflammatory autoimmune demyelinating disease affecting the Central Nervous System, in which Th1 and Th17 cells appear to recognize and react against certain myelin sheath components.Epidemiological evidence has accumulated ...
Jorge eCorreale, Mauricio Franco Farez
doaj   +1 more source

Priming dendritic cells for Th2 polarization: lessons learned from helminths and implications for metabolic disorders

Frontiers in Immunology, 2014
Nearly one quarter of the world’s population is infected with helminth parasites. A common feature of helminth infections is the manifestation of a type 2 immune response, characterized by T helper 2 (Th2) cells that mediate anti-helminth immunity.
Leonie eHussaarts, Maria eYazdanbakhsh, Bruno eGuigas, Bruno eGuigas   +3 more
doaj   +1 more source

Comparative analysis of the immune responses induced by native versus recombinant versions of the ASP-based vaccine against the bovine intestinal parasite Cooperia oncophora [PDF]

, 2018
The protective capacities of a native double-domain activation-associated secreted protein (ndd-ASP)-based vaccine against the cattle intestinal nematode Cooperia oncophora has previously been demonstrated.
Borloo, Jimmy, Casaert, Stijn, Claerebout, Edwin, Geldhof, Peter, González Hernández, Ana, Leclercq, Georges, Peelaers, Iris   +6 more
core   +1 more source

Helminth allergens, parasite-specific IgE and its protective role in human immunity

Frontiers in Immunology, 2014
The Th2 immune response, culminating in eosinophilia and IgE production, is not only characteristic of allergy but also of infection by parasitic worms (helminths).
Colin Matthew Fitzsimmons, Franco Harald Falcone, David W Dunne   +2 more
doaj   +1 more source

Strongy Detect: Preliminary Validation of a Prototype Recombinant Ss-NIE/Ss-IR Based ELISA to Detect Strongyloides stercoralis Infection.

PLoS Neglected Tropical Diseases, 2022
BackgroundStrongyloides stercoralis (Ss) is the etiological agent of strongyloidiasis, a neglected tropical disease of global concern. Laboratory diagnosis of strongyloidiasis is most often based on detection of antibodies against antigens in an enzyme ...
William J Sears, Thomas B Nutman
doaj   +1 more source