Nematode-induced interference with vaccination efficacy targets follicular T helper cell induction and is preserved after termination of infection. [PDF]
PLoS Neglected Tropical Diseases, 2014 One-third of the human population is infected with parasitic worms. To avoid being eliminated, these parasites actively dampen the immune response of their hosts.
Irma Haben +2 more
doaj +1 more source
Immune Responses in Human Necatoriasis: Association between Interleukin-5 Responses and Resistance to Reinfection [PDF]
, 2004 Cytokine and proliferative responses to Necator americanus infection were measured in a treatment-reinfection study of infected subjects from an area of Papua New Guinea where N. americanus is highly endemic.
Brown, A.P. +4 more
core
IL-10- and TGFβ-mediated Th9 Responses in a Human Helminth Infection. [PDF]
PLoS Neglected Tropical Diseases, 2016 Th9 cells are a subset of CD4+ T cells that express the protoypical cytokine, IL-9. Th9 cells are known to effect protective immunity in animal models of intestinal helminth infections.
Rajamanickam Anuradha +7 more
doaj +1 more source
Plasmodium falciparum and Helminth Coinfections Increase IgE and Parasite-Specific IgG Responses
Microbiology Spectrum, 2021 Coinfection with Plasmodium falciparum and helminths may impact the immune response to these parasites because they induce different immune profiles. We studied the effects of coinfections on the antibody profile in a cohort of 715 Mozambican children ...
Rebeca Santano +27 more
doaj +1 more source
Human Schistosome Infection and Allergic Sensitisation [PDF]
, 2012 Several field studies have reported an inverse relationship between the prevalence of helminth infections and that of allergic sensitisation/atopy. Recent studies show that immune responses induced by helminth parasites are, to an extent, comparable to ...
Mutapi, Francisca +2 more
core +3 more sources
Reprogramming macrophages to an anti‐inflammatory phenotype by helminth antigens reduces murine atherosclerosis [PDF]
The FASEB Journal, 2013 Atherosclerosis is a lipid‐driven inflammatory disease of the vessel wall, characterized by the chronic activation of macrophages. We investigated whether the helminth‐derived antigens [soluble egg antigens (SEAs)] could modulate macrophage inflammatory responses and protect against atherosclerosis in mice.
Wolfs, Ine M. J. +16 more
openaire +5 more sources
Brain and Behavior, Volume 16, Issue 4, April 2026.Parasitic infections like schistosomiasis, soil‐transmitted helminths, and malaria can impair nutrient absorption, oxygen supply, and brain function, leading to memory deficits, attention deficits, reduced intelligence quotient, weak academic performance, and motor or executive deficits.
Albertha Maku Adu +7 more
wiley +1 more source
Pathogens, 2021 Excretory/secretory products released by helminth parasites have been widely studied for their diagnostic utility, immunomodulatory properties, as well as for their use as vaccines.
David Becerro-Recio +8 more
doaj +1 more source
Cross antigenicity of immunodominant polypeptides of somatic antigen of Oesophagostomum columbianum with other helminths by western blotting [PDF]
Veterinary World, 2015 Oesophagostomum columbianum in small ruminants in India is found as mixed infection commonly in sheep and goat. Haemonchus contortus, an abomasal nematode is found as concurrent infection with it. Eggs of Haemonchus and O. columbianum cannot be easily distinguished. Diagnosis of O.
Sunita Dalal +3 more
openaire +3 more sources
The role of T cells in sepsis of distinct infectious aetiologies
Clinical and Translational Discovery, Volume 6, Issue 2, April 2026.Pathogen‐specific sepsis induces mitochondrial dysfunction in T cells, leading to functional alterations. Single‐cell transcriptomics reveals subtype‐specific impairments involving reactive oxygen species accumulation, mtDNA damage, calcium dysregulation, and metabolic reprogramming.
Xuanqi Liu +5 more
wiley +1 more source