Results 241 to 250 of about 135,006 (287)

A case of visceral leishmaniasis mimicking connective tissue disease

Rheumatology &Autoimmunity, EarlyView.
Yucui Li, Hongxia Yang, Tingzi Zhao, Ke Xu, Liyun Zhang   +4 more
wiley   +1 more source

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Human platelet antigens in disease

Clinica Chimica Acta, 2018
Platelets have various functions and participate in primary hemostasis, inflammation, and immune responses. Human platelet antigens (HPAs) are alloantigens expressed on the platelet membrane. Each HPA represent one of six platelet glycoproteins GPIIb, GPIIIa, GPIa, GPIbα, GPIbβ, and CD109, and six biallelic systems are grouped.
Ying-Hao Wen, Ding-Ping Chen, Ding-Ping Chen   +2 more
openaire   +3 more sources

Status of the MNSs antigens on human platelets

Transfusion, 1987
A sensitive and specific radioimmunoassay was used to determine whether human platelets possess antigens of the MNSs blood group. Mouse monoclonal IgG anti‐M and anti‐N were purified by Staphylococcus protein A chromatography, labeled with 125I, and incubated with platelet pellets from donors of various MN phenotypes. Human IgG anti‐ M, ‐S, and ‐s were
R. Fraser, A.C. Munro, R.A. Dunstan, Wendell F. Rosse, M.E. Nichols, M.B. Simpson   +5 more
openaire   +3 more sources

Antithrombin III Antigen in Human Platelets

Thrombosis and Haemostasis, 1985
SummaryImmunoreactive AT III was found in human platelets. AT III antigen was quantified in platelets taken from each of 17 healthy donors by a specific competitive enzyme immunoassay using purified AT III and AT III antibodies. AT III antigen levels in extracts of washed platelets disrupted by freezing and thawing ranged from 32 to 140 ng per 109 ...
Andreaux Jp, Martine Alhenc-Gelas, Gorenflot A, Martine Aiach   +3 more
openaire   +3 more sources

Human platelet antigen genotyping of platelet donors in southern Brazil

International Journal of Immunogenetics, 2015
SummaryHuman platelet antigens (HPA) are immunogenic structures that result from single nucleotide polymorphisms (SNPs) leading to single amino acid substitutions. This study sought to determine the allele and genotype frequencies of HPA‐1, HPA‐2, HPA‐3, HPA‐4, HPA‐5 and HPA‐15 in platelet donors from the state of Rio Grande do Sul (RS), Brazil, and ...
J. Merzoni, I. S. Fagundes, L. W. Lunardi, J. D.‐R. Lindenau, B. C. Gil, M. Jobim, V. G. Dias, L. Merzoni, L. Sekine, T. G. H. Onsten, L. F. Jobim   +10 more
openaire   +3 more sources

Lea Blood Group Antigen on Human Platelets

American Journal of Clinical Pathology, 1985
One- and two-stage radioligand assays were used to determine if human platelets possess the Lea antigen. Goat IgG anti-Lea antibody was purified by multiple adsorptions with Le(a-b-) human red blood cells, followed by affinity chromatography with synthetic Lea substance and labeling with 125I.
Marcus B. Simpson, Robert A. Dunstan, Wendell F. Rosse   +2 more
openaire   +2 more sources

Distribution of human platelet antigens in a Chinese population

Tissue Antigens, 1998
Abstract: We report the distribution of the human platelet antigens HPA‐1, ‐2, ‐3, ‐4 and ‐5 as determined using the polymerase chain reaction with sequence‐specific primers in 100 random, healthy Chinese in Hong Kong. The HPA‐1a, ‐2a, ‐4a and ‐5a genes were present in every sample tested, HPA‐1b, ‐2b and ‐5b were rare, and the sample was monomorphic ...
Y.W. Chang, Joannis Mytilineos, Gerhard Opelz, B. R. Hawkins   +3 more
openaire   +3 more sources

Human Leukocyte Antigen Alloimmunization and Alloimmune Platelet Refractoriness

Transfusion Medicine Reviews, 2020
Despite significant advancements in the production of platelet products, storage, and transfusion, transfusion refractoriness remains a significant clinical problem, affecting up to 14% of hematological patients receiving platelet transfusions. Human leukocyte antigen (HLA) alloimmunization is a major cause of immune platelet refractoriness, and its ...
Katerina Pavenski, Anno Saris
openaire   +3 more sources

Quantification of human platelet antigen‐1a antibodies with the monoclonal antibody immobilization of platelet antigens procedure

Transfusion, 2005
BACKGROUND: Fetal‐neonatal alloimmune thrombocytopenia results from a maternal alloimmunization against fetal platelet (PLT) antigens. In Caucasian persons, human PLT antigen‐1a (HPA‐1a) is the most frequently implicated antigen. Our aim was to develop a method supported by a mathematical approach to quantify HPA‐1a antibodies.STUDY DESIGN AND METHODS:
Killie Mette Kjaer, Cécile Kaplan, Maxime Gouet, Anne Husebekk, Gerald Bertrand, Vincent Jallu, Patrick Lambin   +6 more
openaire   +3 more sources

Immunopurification of an S-antigen-like protein from human platelets

Thrombosis Research, 1991
S-antigen (also named arrestin or 48K protein) is a protein abundant in photoreceptor cells of vertebrates and invertebrates. The presently known function of this protein in retina is to arrest the enzymatic cascade of phototransduction in retinal rods, through its binding to photoactivated and phosphorylated rhodopsin.
Jean-Pierre Faure, Ahmad Razaghi, Shah Soltan Mirshahi, Vu Van Tuyen, Massoud Mirshahi   +4 more
openaire   +3 more sources