Results 251 to 260 of about 7,765,953 (292)

Human Leukocyte Antigen Alloimmunization and Alloimmune Platelet Refractoriness

Transfusion Medicine Reviews, 2020
Despite significant advancements in the production of platelet products, storage, and transfusion, transfusion refractoriness remains a significant clinical problem, affecting up to 14% of hematological patients receiving platelet transfusions. Human leukocyte antigen (HLA) alloimmunization is a major cause of immune platelet refractoriness, and its ...
Anno, Saris, Katerina, Pavenski
openaire   +2 more sources

Quantification of human platelet antigen‐1a antibodies with the monoclonal antibody immobilization of platelet antigens procedure

Transfusion, 2005
BACKGROUND: Fetal‐neonatal alloimmune thrombocytopenia results from a maternal alloimmunization against fetal platelet (PLT) antigens. In Caucasian persons, human PLT antigen‐1a (HPA‐1a) is the most frequently implicated antigen. Our aim was to develop a method supported by a mathematical approach to quantify HPA‐1a antibodies.STUDY DESIGN AND METHODS:
Gérald, Bertrand, Vincent, Jallu, Maxime, Gouet, Killie Mette, Kjaer, Patrick, Lambin, Anne, Husebekk, Cécile, Kaplan   +6 more
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Antigens of Human Trophoblast: Trophoblast‐Lymphocyte Cross‐Reactive Antigens on Platelets*

American Journal of Reproductive Immunology and Microbiology, 1987
ABSTRACT: Human and rabbit antibodies to trophoblast‐lymphocyte cross‐reactive (TLX) antigens were employed in an enzyme‐linked immunosorbent assay (ELISA) to identify and characterize the TLX alloantigen system on human platelets. Neither washing nor extraction in chaotrope or acid altered platelet TLX.
T, Kajino, W P, Faulk, J A, McIntyre
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Establishment of reference panel for human platelet antigen genotyping

Vox Sanguinis, 2014
Background and ObjectivesHuman platelet antigens (HPAs) are platelet‐specific alloantigens associated with polymorphisms of platelet surface glycoproteins (GPs), and they can induce alloantibodies when individuals lacking a particular polymorphism are exposed to them via pregnancy or transfusion.
R S, Li, Z L, Qiao, B, Ling, P, Lu
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Frequency distribution of human platelet antigens in the Indian population

Transfusion Medicine, 2005
summary.  This study was undertaken with an aim of establishing the frequency distribution of various human platelet antigens (HPA) in Indian populations by means of DNA‐based technology. A total of 1164 people belonging to various population groups were studied for the frequency distribution of HPA.
B, Kulkarni, D, Mohanty, K, Ghosh
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Presence of P Blood Group Antigens on Human Platelets

American Journal of Clinical Pathology, 1985
Except for ABH antigens, the presence of red cell (RBC) antigens on human platelets has been a source of disagreement among investigators. Because ABH antigens share precursor sequences with P-system saccharides, the authors examined human platelets for evidence of P blood group antigens.
R A, Dunstan, M B, Simpson, W F, Rosse
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Retention of HLA Antigens on Previously Frozen Human Platelets

Transfusion, 1980
Recent technical achievements allow satisfactory cryopreservation of human platelets that, after thawing and washing, maintain functional viability for therapeutic use. We have now demonstrated that such previously frozen platelets retain full HLA antigenic activity in spite of the combination of freezing, thawing, and washing procedures and the ...
M S, Pollack, C G, Zaroulis, J, Klainbard, I Z, Leiderman, B, Dupont   +4 more
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Gene frequencies of human platelet antigens in the Tunisian population

Tissue Antigens, 1999
Abstract:Gene frequencies for the human platelet antigens HPA‐1, ‐3 and ‐5 in the Tunisian population were determined by polymerase chain reaction‐restriction fragment length polymorphism (PCR‐RFLP) on 93 volunteer blood donors (78 were tested for HPA‐1, 90 for HPA‐3 and 93 for HPA‐5).
N, Mojaat, L, Halle, V, Proulle, S, Hmida, L, Ben Hamed, K, Boukef, C, Kaplan   +6 more
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Human platelet‐specific antigen frequencies in Indonesian population

Transfusion Medicine, 2013
SUMMARYBackgroundAlloantibodies against human platelet antigens (HPAs) are responsible for the development of alloimmune thrombocytopenia including platelet transfusion refractoriness (PTR) and neonatal alloimmune thrombocytopenia (NAIT). Therefore, transfusion of HPA‐compatible platelets is of importance for the management of these diseases ...
, Asmarinah, R, Dharma, N K, Ritchie, S, Rahayu, E, Putricahya, S, Santoso   +5 more
openaire   +2 more sources

Human platelet antigens frequencies in Maori and Polynesian populations

Transfusion Medicine, 2013
SUMMARYBackgroundAllele frequencies of human platelet antigens (HPA) reflect population history and possibility of platelet‐specific alloimmunization. Here, we report on screening of variants at HPA loci for Polynesian and Maori subjects.ObjectivesOur aims are to evaluate new HPA genotyping methods, compile and analyse new HPA datasets for these ...
Edinur, H., J Dunn, P., Lea, Rodney, hambers, G.   +3 more
openaire   +3 more sources