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Establishment of reference panel for human platelet antigen genotyping
Vox Sanguinis, 2014Background and ObjectivesHuman platelet antigens (HPAs) are platelet‐specific alloantigens associated with polymorphisms of platelet surface glycoproteins (GPs), and they can induce alloantibodies when individuals lacking a particular polymorphism are exposed to them via pregnancy or transfusion.
R S, Li, Z L, Qiao, B, Ling, P, Lu
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Human Leukocyte Antigen Alloimmunization and Alloimmune Platelet Refractoriness
Transfusion Medicine Reviews, 2020Despite significant advancements in the production of platelet products, storage, and transfusion, transfusion refractoriness remains a significant clinical problem, affecting up to 14% of hematological patients receiving platelet transfusions. Human leukocyte antigen (HLA) alloimmunization is a major cause of immune platelet refractoriness, and its ...
Anno, Saris, Katerina, Pavenski
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Frequency distribution of human platelet antigens in the Indian population
Transfusion Medicine, 2005summary. This study was undertaken with an aim of establishing the frequency distribution of various human platelet antigens (HPA) in Indian populations by means of DNA‐based technology. A total of 1164 people belonging to various population groups were studied for the frequency distribution of HPA.
B, Kulkarni, D, Mohanty, K, Ghosh
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Presence of P Blood Group Antigens on Human Platelets
American Journal of Clinical Pathology, 1985Except for ABH antigens, the presence of red cell (RBC) antigens on human platelets has been a source of disagreement among investigators. Because ABH antigens share precursor sequences with P-system saccharides, the authors examined human platelets for evidence of P blood group antigens.
R A, Dunstan, M B, Simpson, W F, Rosse
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Retention of HLA Antigens on Previously Frozen Human Platelets
Transfusion, 1980Recent technical achievements allow satisfactory cryopreservation of human platelets that, after thawing and washing, maintain functional viability for therapeutic use. We have now demonstrated that such previously frozen platelets retain full HLA antigenic activity in spite of the combination of freezing, thawing, and washing procedures and the ...
M S, Pollack +4 more
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Gene frequencies of human platelet antigens in the Macedonian population
Tissue Antigens, 2006AbstractHuman platelet antigen (HPA) systems consist of more than 12 bi‐allelic antigen polymorphisms. Due to these polymorphisms, platelet‐membrane glycoproteins can be recognized as alloantigens or autoantigens and can cause conditions such as fetomaternal alloimmune thrombocytopenia, post‐transfusion refractoriness to platelets, and post‐transfusion
M, Pavkovic +5 more
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Gene frequencies of human platelet antigens in the Tunisian population
Tissue Antigens, 1999Abstract:Gene frequencies for the human platelet antigens HPA‐1, ‐3 and ‐5 in the Tunisian population were determined by polymerase chain reaction‐restriction fragment length polymorphism (PCR‐RFLP) on 93 volunteer blood donors (78 were tested for HPA‐1, 90 for HPA‐3 and 93 for HPA‐5).
N, Mojaat +6 more
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Human Platelet Antigen Gene Frequencies in the Austrian Population
Haemostasis, 2009Gene frequencies for the human platelet antigen systems HPA-1, -2, -3, and -5 were determined directly from DNA isolated from cord blood of more than 900 randomly selected Caucasoid newborns in Vienna, Austria. Genotyping was performed by specific amplification of the respective regions coding for platelet glycoproteins GP lb, IIb, IIIa, and la by PCR.
A, Holensteiner +5 more
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Human platelet antigen‐1a antibodies induce the release of the chemokine RANTES from human platelets
Vox Sanguinis, 2001Background and ObjectiveBinding of human platelet antigen‐1a (HPA‐1a)‐specific antibodies to target platelets can trigger platelet activation and mediator release. Here we tested the effect of HPA‐1a antibody‐containing sera on platelet release of the chemokine RANTES (regulated on activation, normal, T‐cell expressed, and presumably secreted) in vitro.
M, Dettke +3 more
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Genotyping of Human Platelet Antigens by BeadChip Microarray Technology
2015Human platelet antigen (HPA) typing plays a critical role in the diagnosis of fetal/neonatal alloimmune thrombocytopenia, and the prevention of posttransfusion purpura and refractoriness to platelet transfusions. The recent development of high-throughput genotyping methods, allowing simultaneous genotyping of as many as 17 HPAs, is of utmost interest ...
Gerald, Bertrand, Fabiana, Conti
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