Results 241 to 250 of about 8,144,327 (289)

Human platelet antigens in disease

Clinica Chimica Acta, 2018
Platelets have various functions and participate in primary hemostasis, inflammation, and immune responses. Human platelet antigens (HPAs) are alloantigens expressed on the platelet membrane. Each HPA represent one of six platelet glycoproteins GPIIb, GPIIIa, GPIa, GPIbα, GPIbβ, and CD109, and six biallelic systems are grouped.
Ying-Hao, Wen, Ding-Ping, Chen
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Molecular Genetics of Human Platelet Antigens

Infusionstherapie und Transfusionsmedizin / Infusion Therapy and Transfusion Medicine, 2009
The purpose of this article is to review the molecular genetics of human platelet antigens, the application of molecular biological techniques to detect mutations underlying polymorphisms and the importance of these techniques for clinical medicine of immunemediated platelet destruction.
S, Simsek, A E, von dem Borne
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Status of the MNSs antigens on human platelets

Transfusion, 1987
A sensitive and specific radioimmunoassay was used to determine whether human platelets possess antigens of the MNSs blood group. Mouse monoclonal IgG anti‐M and anti‐N were purified by Staphylococcus protein A chromatography, labeled with 125I, and incubated with platelet pellets from donors of various MN phenotypes. Human IgG anti‐ M, ‐S, and ‐s were
M B, Simpson, R A, Dunstan, W F, Rosse, A C, Munro, R, Fraser, M E, Nichols   +5 more
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Antithrombin III Antigen in Human Platelets

Thrombosis and Haemostasis, 1985
SummaryImmunoreactive AT III was found in human platelets. AT III antigen was quantified in platelets taken from each of 17 healthy donors by a specific competitive enzyme immunoassay using purified AT III and AT III antibodies. AT III antigen levels in extracts of washed platelets disrupted by freezing and thawing ranged from 32 to 140 ng per 109 ...
M L, Alhenc-Gelas, M, Aiach, A, Gorenflot, J P, Andreaux   +3 more
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Human platelet antigen genotyping of platelet donors in southern Brazil

International Journal of Immunogenetics, 2015
SummaryHuman platelet antigens (HPA) are immunogenic structures that result from single nucleotide polymorphisms (SNPs) leading to single amino acid substitutions. This study sought to determine the allele and genotype frequencies of HPA‐1, HPA‐2, HPA‐3, HPA‐4, HPA‐5 and HPA‐15 in platelet donors from the state of Rio Grande do Sul (RS), Brazil, and ...
J. Merzoni, I. S. Fagundes, L. W. Lunardi, J. D.‐R. Lindenau, B. C. Gil, M. Jobim, V. G. Dias, L. Merzoni, L. Sekine, T. G. H. Onsten, L. F. Jobim   +10 more
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Distribution of human platelet antigens in a Chinese population

Tissue Antigens, 1998
Abstract: We report the distribution of the human platelet antigens HPA‐1, ‐2, ‐3, ‐4 and ‐5 as determined using the polymerase chain reaction with sequence‐specific primers in 100 random, healthy Chinese in Hong Kong. The HPA‐1a, ‐2a, ‐4a and ‐5a genes were present in every sample tested, HPA‐1b, ‐2b and ‐5b were rare, and the sample was monomorphic ...
Y W, Chang, J, Mytilineos, G, Opelz, B R, Hawkins   +3 more
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Lea Blood Group Antigen on Human Platelets

American Journal of Clinical Pathology, 1985
One- and two-stage radioligand assays were used to determine if human platelets possess the Lea antigen. Goat IgG anti-Lea antibody was purified by multiple adsorptions with Le(a-b-) human red blood cells, followed by affinity chromatography with synthetic Lea substance and labeling with 125I.
R A, Dunstan, M B, Simpson, W F, Rosse
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Quantification of human platelet antigen‐1a antibodies with the monoclonal antibody immobilization of platelet antigens procedure

Transfusion, 2005
BACKGROUND: Fetal‐neonatal alloimmune thrombocytopenia results from a maternal alloimmunization against fetal platelet (PLT) antigens. In Caucasian persons, human PLT antigen‐1a (HPA‐1a) is the most frequently implicated antigen. Our aim was to develop a method supported by a mathematical approach to quantify HPA‐1a antibodies.STUDY DESIGN AND METHODS:
Gérald, Bertrand, Vincent, Jallu, Maxime, Gouet, Killie Mette, Kjaer, Patrick, Lambin, Anne, Husebekk, Cécile, Kaplan   +6 more
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Antigens of Human Trophoblast: Trophoblast‐Lymphocyte Cross‐Reactive Antigens on Platelets*

American Journal of Reproductive Immunology and Microbiology, 1987
ABSTRACT: Human and rabbit antibodies to trophoblast‐lymphocyte cross‐reactive (TLX) antigens were employed in an enzyme‐linked immunosorbent assay (ELISA) to identify and characterize the TLX alloantigen system on human platelets. Neither washing nor extraction in chaotrope or acid altered platelet TLX.
T, Kajino, W P, Faulk, J A, McIntyre
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Human platelet‐specific antigen frequencies in Indonesian population

Transfusion Medicine, 2013
SUMMARYBackgroundAlloantibodies against human platelet antigens (HPAs) are responsible for the development of alloimmune thrombocytopenia including platelet transfusion refractoriness (PTR) and neonatal alloimmune thrombocytopenia (NAIT). Therefore, transfusion of HPA‐compatible platelets is of importance for the management of these diseases ...
, Asmarinah, R, Dharma, N K, Ritchie, S, Rahayu, E, Putricahya, S, Santoso   +5 more
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