Results 231 to 240 of about 7,765,953 (292)

Epigenetic Regulation of Liver Fibrosis: Mechanisms and Therapeutic Implications

Portal Hypertension &Cirrhosis, EarlyView.
This review synthesizes the epigenetic mechanisms—DNA methylation, histone modifications, and non‐coding RNAs—that drive hepatic stellate cell activation and the progression of liver fibrosis. It further evaluates emerging therapeutic strategies targeting these epigenetic regulators, including DNA methyltransferase and histone deacetylase inhibitors ...
Maryam Jadid Tavaf, Mahboobeh Ebrahimi Varkiani, Saeid Abroun, Pedram Asadi‐Sarabi, Shukoofeh Torabi, Elham Rismani, Mohammad Majd Hammour, Andreas K. Nüssler, Massoud Vosough   +8 more
wiley   +1 more source

Antibody Responses Against Swine Leukocyte Antigens Contribute to Early Rejection After Pig-To-Monkey Kidney Xenotransplantation. [PDF]

HLA
Feng H, Zhang M, Du J, Li T, Chen S, Guo H, Yang YG, Wang Y, Pan D, Zhu L, Chen G.   +10 more
europepmc   +1 more source

Piper nigrum Has an Antitumor Effect Through Regulation of the Phosphatidylinositol 3‐Kinase Signaling Pathway in a Murine Model of Acute Myeloid Leukemia

Phytotherapy Research, EarlyView.
Overview of the antileukemic effects of Piper nigrum extract in AML. P. nigrum reduced leukemic cell proliferation and glycolytic metabolism through modulation of the PI3K/AKT/mTOR pathway. In vivo, treatment reduced leukemic burden, improved hematological parameters, prolonged survival, and modulated antitumor immune responses.
Natalia Murillo, Paola Lasso, Claudia Urueña, Susana Fiorentino   +3 more
wiley   +1 more source

Immune complex handling in transplantation: central roles for complement factor H, animal models, and translational implications. [PDF]

Front Immunol
Quigg RJ, Alexander JJ.
europepmc   +1 more source

Mechanistic Evaluation of Luteolin in Wound Healing of Diabetic Foot Ulcer via Nrf2 Signaling

Phytotherapy Research, EarlyView.
Proposed mechanism by which Luteolin (LU) promotes diabetic foot ulcer healing. LU attenuates hyperglycemia‐induced oxidative stress and lipid peroxidation, improves endothelial cell viability, and suppresses ferroptosis through Nrf2‐dependent antioxidant signaling, thereby accelerating angiogenesis and wound repair. ABSTRACT Diabetic foot ulcers (DFUs)
Muhammed Yusuf, Ayfer Busra Benkli, Ramiz Yusuf   +2 more
wiley   +1 more source

Fundamentals of big data and artificial intelligence in transfusion medicine. [PDF]

Vox Sang
Turki AT, Brieske CM, Gurkan UA, Scheidler KM, Usta OB, Turkulainen E, Arzideh K, Temme C, Hosch R, Horn PA, Arvas M.   +10 more
europepmc   +1 more source

Immunomodulatory Properties of Withania somnifera: Regulation of Innate Immune Cells and Clinical Implications

Phytotherapy Research, EarlyView.
ABSTRACT Withania somnifera (L.) Dunal (WS), commonly known as Ashwagandha, is a prominent medicinal herb in Ayurveda, with extensive therapeutic potential attributed to its diverse phytochemical profile. This review critically examines the immunomodulatory properties of WS, focusing on innate immune cell populations, including neutrophils, eosinophils,
Rana Yukta, Sonalika Gupta, Gagandeep Kaur, Partha Sarathi Mondal, Milirani Das, Anagha Ranade, Alok Kumar Srivastava, Sachin Kumar, Manoj Kumar Barthwal, Madhu Dikshit   +9 more
wiley   +1 more source

In the age of mRNA vaccines: Linear or circular mRNA? [PDF]

Mol Ther Nucleic Acids
Lundstrom K.
europepmc   +1 more source

Transfusing HPA-mismatched platelets to mimic fetomaternal hemorrhage elicits fetal/neonatal alloimmune thrombocytopenia. [PDF]

Blood
Zhi H, Sheridan D, Newman PJ, Newman DK.
europepmc   +1 more source

Enhanced type I interferon signature in primary APS patients is associated with thrombocytopenia. [PDF]

Front Immunol
Scholz S, Nitschke E, Dreveton LS, Wiedemann A, Assefa B, Szelinski F, Schrezenmeier E, Pruß A, Krönke G, Dörner T, Stefanski AL.   +10 more
europepmc   +1 more source