Results 61 to 70 of about 56,164 (204)

2-Arachidonoylglycerol enhances platelet formation from human megakaryoblasts [PDF]

, 2014
Platelets modulate vascular system integrity, and their loss is critical in haematological pathologies and after chemotherapy. Therefore, identification of molecules enhancing platelet production would be useful to counteract thrombocytopenia.
Gasperi, V, Mauro Maccarrone, Chiurchiù, V, ODDI, Sergio, Lanuti, M, Valerio Chiurchiù, Avigliano, L, Oddi, S, CATANI, MARIA VALERIA, AVIGLIANO, LUCIANA, Daniela Evangelista, Maria Valeria Catani, Luciana Avigliano, Evangelista, D, Maccarrone, M, GASPERI, VALERIA, Valeria Gasperi, LANUTI, MIRKO, Catani, MV   +18 more
core   +1 more source

Human platelet antigen polymorphisms and the risk of chronic Chagas disease cardiomyopathy

Platelets, 2020
Human platelet antigen (HPA) polymorphisms are considered to be a risk factor for cardiac and vascular diseases, but the role of HPA in chronic Chagas disease cardiomyopathy (CCC) is not available.
Deborah Elzita do Carmo Corrêa, Christiane Maria Ayo, Jeane Eliete Laguila Visentainer, Eliane Papa Ambrosio-Albuquerque, Pâmela Guimarães Reis, Cinara Cássia Brandão de Mattos, Reinaldo Bulgarelli Bestetti, Luiz Carlos de Mattos, Ana Maria Sell   +8 more
doaj   +1 more source

Laboratory analyses for evaluation of platelet disorders and platelet concentrates

, 2006
High quality of platelet analytics requires specialized knowledge and skills. It was applied to analyze platelet activation and aggregation responses in a prospective controlled study of patients with Finnish type of amyloidosis.
Javela, Kaija
core  

Unlocked nucleic acid modified primer-based enzymatic polymerization assay: Towards allele-specific genotype detection of human platelet antigens [PDF]

, 2018
Accurate detection of single nucleotide polymorphisms (SNPs) is paramount for the appropriate therapeutic intervention of debilitating diseases associated with SNPs.
Jørgensen, Per T., Veedu, Rakesh N., Le, Bao T., Rakesh, Shilpa, Baker, Ross, Baker, R., Veedu, R.N., Wengel, Jesper, Hughes, Quintin, Le, B.T., Jørgensen, P.T., Wengel, J., Hughes, Q., Rakesh, S.   +13 more
core   +1 more source

In vitro expression analysis of the ITGB3 c.598G/A mutation and its association with FNAIT

Zhongguo shuxue zazhi
[Objective] To explore the role of the c.598G>A mutation of the ITGB3 gene in the occurrence of fetal and neonatal alloimmune thrombocytopenia (FNAIT) through its expression in vitro.
DING Haoqiang, YE Xin, XU Xiuzhang, XIA Wenjie, DENG Jing, LIU Jing, CHEN Yangkai, CHEN Dawei, XU Yaori   +8 more
doaj   +1 more source

Frequency of human platelet antigens in oncohematological patients with thrombocytopenia and the probability of incompatibility to platelet transfusions Frequência dos antígenos plaquetários humanos (HPA) em pacientes trombocitopênicos e predisposição à incompatibilidade transfusional

Revista Brasileira de Hematologia e Hemoterapia, 2012
OBJECTIVE: The objective of this study was to evaluate the frequencies of human platelet antigens in oncohematological patients with thrombocytopenia and to analyze the probability of their incompatibility with platelet transfusions.
Juliana Vieira dos Santos Bianchi, Maria Regina Andrade de Azevedo, Eduardo Jens, Youko Nukui, Dalton Alencar Ficher Chamone   +4 more
doaj   +1 more source

Novel method for simultaneously detecting HPA and HLA antibodies using Luminex microbeads

Journal of Translational Medicine, 2019
Background Alloantibodies against human platelet antigens (HPAs) and human leukocyte antigen (HLA) are implicated in several immune-mediated platelet disorders.
Sudan Tao, Shu Chen, Xiaozhen Hong, Ji He, Faming Zhu   +4 more
doaj   +1 more source

Immunological platelet transfusion refractoriness: current insights from mechanisms to therapeutics

Platelets
Although there have been tremendous improvements in the production and storage of platelets, platelet transfusion refractoriness (PTR) remains a serious clinical issue that may lead to various severe adverse events.
Xiaoyu Chen, Yuhong Zhao, Yan Lv, Jue Xie   +3 more
doaj   +1 more source

Purification and partial characterization of CD9 antigen of human platelets

FEBS Letters, 1990
CD9 antigen (p24) was purified from human platelets and partially characterized. The yield was 75 μg from 10 units of platelet concentrates. p24 (38 000 copies/platelet) has intramolecular disulfide bond(s) and, in SDS‐PAGE, consists of major 24‐kDa molecule and minor 26‐ to 31‐kDa molecules.
Higashihara, Masaaki, Takahata, Kyoya, Yatomi, Yutaka, Nakahara, Kazuhiko, Kurokawa, Kiyoshi   +4 more
openaire   +2 more sources

Platelet compatibility and platelet antibodies detection: A step towards resolving dilemma in management of platelet refractoriness in oncology patients

Global Journal of Transfusion Medicine, 2019
Background: Platelet refractoriness complicates the provision of platelet transfusions- a critical and essential part in management of thrombocytopenia in Oncology patients. Platelet refractoriness poses challenge due to alloimmunization to HLA (Class I)
Sadhana Mangwana, Atin Kacker, Nikhil Simon   +2 more
doaj   +1 more source