Results 61 to 70 of about 12,887 (114)

Molecular characterization of a synthetic neutralizing antibody targeting p67 of Theileria parva

Protein Science, Volume 34, Issue 6, June 2025.
Abstract The Theileria parva sporozoite surface antigen p67 is a target of the bovine humoral immune response that generates antibodies capable of providing protection against subsequent infection. As a result, p67 has been the subject of efforts aimed at the development of an anti‐sporozoite subunit vaccine.
Shane Miersch, Alex U. Singer, Chao Chen, Fred Fellouse, Anupriya Gopalsamy, Luciano Silva e Costa, Anna Lacasta, Hannah Chege, Naomi Chege, Vishvanath Nene, Sachdev S. Sidhu   +10 more
wiley   +1 more source

CXCL10highTNFαhighKi67+ Microglia Recruit and Activate CD8+ T Cells in the Brainstem During Experimental Cerebral Malaria

CNS Neuroscience &Therapeutics, Volume 31, Issue 6, June 2025.
Microglia exhibit distinct transcriptional and morphological heterogeneity in experimental cerebral malaria (ECM) compared to physiological microglia. A unique subtype of ECM‐associated microglia, characterized by CXCL10highTNFαhighKi67+, mediates the recruitment and sustained activation of CD8+ T cells through ongoing interactions, exacerbating ...
Yi Wang, Jiao Liang, Chao Yang, Jun Wang, Qinghao Zhu, Guodong Tong, Tong Li, Ganze Li, Yuxiao Huang, Yimin Yang, Jie Ren, Yinghui Li, Yan Shen, Ya Zhao   +13 more
wiley   +1 more source

The Genesis of Malaria: The Origin of Mosquitoes and Their Protistan Cargo, Plasmodium falciparum [PDF]

, 2013
Malaria is caused by the parasite belonging to the genus Plasmodium; however, creation biologists maintain this organism was not always parasitic. Plasmodium is probably a degenerate form of algae.
Gillen, Alan L., Sherwin, Frank
core   +1 more source

Transnuclear CD8 T cells specific for the immunodominant epitope Gra6 lower acute-phase Toxoplasma gondii burden. [PDF]

, 2016
We generated a CD8 T-cell receptor (TCR) transnuclear (TN) mouse specific to the Ld -restricted immunodominant epitope of GRA6 from Toxoplasma gondii as a source of cells to facilitate further investigation into the CD8 T-cell-mediated response against ...
Blanchard, Nicolas, Dougan, Stephanie K, Frickel, Eva-Maria, Jackson, John, Ploegh, Hidde, Sanecka, Anna, Shastri, Nilabh, Yoshida, Nagisa   +7 more
core   +2 more sources

Cytotoxic Signature and IFN‐γ Production Dominate CD4+ T‐Cell Response During Human Toxoplasmosis

Immunology, Volume 175, Issue 2, Page 151-164, June 2025.
Overview of CD4+ T‐cell subsets in patients with toxoplasmosis. Schematic drawing summarising the most important alterations in CD4+ T‐cell subsets, illustrated in different colours, from patients in distinct stages of toxoplasmosis, represented with different colours, with (lesion) or without (no lesion) ocular manifestations.
Priscilla Miranda Henriques, Gregório Guilherme Almeida, Inga Rimkute, Luara Isabela dos Santos, Thomas Liechti, Ana Paula Marino, Isabela Natália Pascoal Campos do Vale, Daniel Vitor Vasconcelos‐Santos, Olindo Assis Martins‐Filho, Ricardo Tostes Gazzinelli, Mario Roederer, Alan Sher, Andréa Teixeira‐Carvalho, Dragana Jankovic, Lis Ribeiro do Valle Antonelli   +14 more
wiley   +1 more source

The importance of vertical transmission of Neospora sp. in naturally infected horses [PDF]

, 2012
Neospora spp. is a intracellular protozoan phylogenetically closely related to Toxoplasma gondii and Sarcocystis neurona, and it can infect horses leading to the development of reproductive or neurological diseases.
Ana Maria Antonello, Felipe Lamberti Pivoto, Giovana Camillo, Patricia Braunig, Luis Antonio Sangioni, Endrigo Pompermayer, Fernanda Silveira Flores Vogel, Abd-Elnaeim, Anderson, Ciaramella, Conrad, Cook, Dubey, Dubey, Dubey, Finno, Finno, Gondim, Gondim, Gupta, Hietala, Hoane, King, Kligler, Kormann, Locatelli-Dittrich, McAllister, Pare, Pitel, Pusterla, Toscan, Vardeleon   +31 more
core   +3 more sources

Chemical Protein Engineering: Backbone Cyclization Rescues Folding of a 183‐Residue Truncated Domain of Malaria Parasite Protein PfAMA1

Chemistry – A European Journal, Volume 31, Issue 28, May 19, 2025.
We report the first chemical synthesis of a 183‐residue functional truncated cyclic PfAMA1 domain I protein using multi‐segment native chemical ligation and head‐to‐tail cyclization to introduce conformational constraints, thereby facilitating protein folding and providing novel strategies for miniature protein engineering.
Jamsad Mannuthodikayil, Vishal Malik, Abhisek Kar, Sameer Singh, Kalyaneswar Mandal   +4 more
wiley   +1 more source

Molecular characteristics of an immobilization antigen gene of the fish-parasitic protozoanIchthyophthirius multifiliisstrain ARS-6

Aquaculture Research, 2009
AbstractIchthyophthirius multi¢liis(Ich), a ciliated protozoanparasite of ¢sh, expresses surface antigens (i-anti-gens), which react with host antibodies that renderthemimmobile.Thenucleotidesequenceofani-anti-gen gene of I. multi¢liis strain ARS-6 was deduced.The predicted protein of 47493Da is comprised of460 amino acids (aa’s) arranged into ¢ve ...
Zhanjiang Liu, Jason Abernathy, Riccardo Russo, Phillip H. Klesius, De-Hai Xu, Kevin Dybvig, Vicky L. van Santen, Victor S. Panangala   +7 more
openaire   +2 more sources

Evolution of Our Understanding of Myeloid Regulatory Cells: From MDSCs to Mregs [PDF]

, 2014
The term myeloid-derived suppressor cells (MDSCs) was first suggested in 2007 in order to reflect the origin and function of myeloid cells during immunosuppression in cancer and other pathologic conditions.
Manjili, Masoud H.
core   +1 more source

Frontiers of parasitology research in the People's Republic of China : infection, diagnosis, protection and surveillance [PDF]

, 2012
: Control and eventual elimination of human parasitic diseases in the People's Republic of China (P.R. China) requires novel approaches, particularly in the areas of diagnostics, mathematical modelling, monitoring, evaluation, surveillance and public ...
Bergquist, R., Chen, J. H., Chen, J. X., Tanner, M., Utzinger, J., Wang, H., Zhou, X. N.   +6 more
core   +2 more sources