Results 161 to 170 of about 44,256 (203)

Immune activation with peptide assemblies carrying Lewis y tumor‐associated carbohydrate antigen

Journal of Peptide Science, 2016
Molecular assemblies varying morphologies in a wide range from spherical micelle, nanosheet, curved sheet, nanotube and vesicle were prepared and loaded with Lewis y (Ley) tumor‐associated carbohydrate antigen on the assembly surface. The molecular assemblies were composed of poly(sarcosine)m‐block‐poly(L‐lactic acid)30 (m = 15 or 50, Lactosome), poly ...
Yuji, Yamazaki, Naoki, Watabe, Hiroaki, Obata, Eri, Hara, Masashi, Ohmae, Shunsaku, Kimura   +5 more
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Synthesis of Fluorinated Analogues of Tumor-Associated Carbohydrate and Glycopeptide Antigens

Synlett, 2009
Partial structures of tumor-associated mucin glycoproteins are interesting target structures for the development of selective anticancer vaccines. To probe the effect of fluorination on the immunological and metabolic properties of mucin glycopeptides, six novel fluorinated glycosyl-threonine conjugates have been synthesized.
Anja Hoffmann-Röder, Christian Mersch, Sarah Wagner   +2 more
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Aberrant Glycosylation In Tumors And Tumor-Associated Carbohydrate Antigens

1989
Publisher Summary Aberrant glycosylation is the most common phenomenon associated with oncogenic transformation expressed in cell membranes of animal and human cancer cells. Such aberrant structures at the surface membranes may well be effective targets in prevention, diagnosis, and treatment of human cancer.
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Multivalent antibody fragments with high functional affinity for a tumor-associated carbohydrate antigen.

The Journal of Immunology, 1996
Abstract We report in this work a human-derived self-assembling polypeptide based on the tetramerization domain of the human transcription factor p53, which can be fused to single-chain Fv Ab (scFv) fragments via a long and flexible hinge sequence of human origin, allowing exploitation of the functional affinity increase of binding to a ...
Rheinnecker, M., Hardt, C., Ilag, L., Kufer, P., Gruber, R., Hoess, A., Lupas, A. ; https://orcid.org/0000-0002-1959-4836, Rottenberger, C., Plückthun, A., Pack, P.   +9 more
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[Tumor-associated carbohydrate antigens related to blood group carbohydrates].

Gan to kagaku ryoho. Cancer & chemotherapy, 1986
Biochemical studies have revealed the alteration of carbohydrate structures of cell membrane glycolipids, glycoproteins and cell secretory products associated with neoplastic transformation. Immunohistochemical examination of the blood group carbohydrate antigens in various cancer tissues have revealed the following results.
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Possible roles of tumor-associated carbohydrate antigens.

Cancer research, 1996
Recent progress in the studies on the roles of carbohydrates has brought about critical discoveries, which allow us to have working hypotheses for understanding the roles of tumor-associated carbohydrate antigens. In this report, I focus my description on three different aspects of this progress.
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Chapter 4 Tumor-associated carbohydrate antigens and modified blood group antigens

1996
Publisher Summary This chapter discusses the present knowledge of tumor-associated carbohydrate antigens (TACA's). It also discusses the pathobiological and functional significance of TACA's. A large number of monoclonal antibody (mAbs) showed distinctive reactivity with tumor cells but not with normal cells were found to be directed to carbohydrate ...
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[Immunotherapy Targeting Tumor-Associated Carbohydrate Antigens in Deficient Mismatch Repair Colorectal Cancer].

Gan to kagaku ryoho. Cancer & chemotherapy, 2021
The Tn antigen is the most prevalent tumor-associated carbohydrate antigen. It interacts with macrophage galactose-specific lectin(MGL)on dendric cells and macrophages, driving immune inhibitory signals. Colorectal cancer(CRC)exhibiting deficient mismatch repair(dMMR)is characterized by tumor-infiltrating lymphocytes(TILs), the expression of immune ...
Takuro, Matsumoto, Hirokazu, Okayama, Hiroshi, Nakano, Misato, Ito, Shotaro, Nakajima, Motonobu, Saito, Zenichiro, Saze, Tomoyuki, Momma, Kosaku, Mimura, Koji, Kono   +9 more
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Humoral immune responses to tumor-associated carbohydrate antigens.

Seminars in cancer biology, 1992
Antibodies to carbohydrate structures are quite commonly found in human sera. Normal individuals, as well as individuals with autoimmune diseases and cancer, produce antibodies reacting with a variety of carbohydrate determinants. These determinants can be expressed on glycoproteins, mucins or glycosphingolipids.
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Tumor‐associated carbohydrate antigens

Journal of Oral Pathology & Medicine, 1987
E, Dabelsteen, H, Clausen
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