Results 251 to 260 of about 45,582 (279)

Tumor‐associated carbohydrate antigens: A possible avenue for cancer prevention

Immunology & Cell Biology, 2005
Here we examine the use of glycopeptides containing tumour‐associated carbohydrate antigens (TACA) as potential preventive vaccines for carcinomas. Our recent results suggest that CD8+ T cells (CTL) are capable of recognizing TACA in a conventional class I MHC‐restricted fashion.
Yanfei, Xu, Alessandro, Sette, John, Sidney, Sandra J, Gendler, Alessandra, Franco   +4 more
openaire   +2 more sources

Possible functions of tumor-associated carbohydrate antigens

Current Opinion in Immunology, 1991
Expression of some tumor-associated carbohydrate antigens may define the stage, rate and phenotype of tumor progression and may have prognostic value. Some of these antigens are now recognized as adhesion molecules that define the site of metastasis. Monoclonal antibodies to tumor-associated carbohydrate antigens, or the antigens themselves, may serve ...
openaire   +2 more sources

Elevation of Tumor-associated Carbohydrate Antigens in Patients with Diffuse Panbronchiolitis

American Review of Respiratory Disease, 1993
We investigated the serum levels of the tumor-associated carbohydrate antigens sialyl SSEA-1 (SLX) and sialyl Lewis(a) (CA19-9) in patients with diffuse panbronchiolitis (DPB) and other nonmalignant lung diseases. Both antigens were high in the serum and bronchoalveolar lavage fluid (BALF) of patients with DPB, bronchiectasis (BE), idiopathic pulmonary
H, Mukae, M, Hirota, S, Kohno, K, Komori, K, Fukushima, K, Hiratani, J, Kadota, K, Hara   +7 more
openaire   +2 more sources

Recent Advance in Tumor-associated Carbohydrate Antigens (TACAs)-based Antitumor Vaccines

ACS Chemical Biology, 2016
Cancer cells can be distinguished from normal cells by displaying aberrant levels and types of carbohydrate structures on their surfaces. These carbohydrate structures are known as tumor-associated carbohydrate antigens (TACAs). TACAs were considered as promising targets for the design of anticancer vaccines. Unfortunately, carbohydrates alone can only
Danyang, Feng, Abdul Sami, Shaikh, Fengshan, Wang   +2 more
openaire   +2 more sources

Tumor-associated carbohydrate antigens in primary pulmonary adenocarcinomas and their metastases

Human Pathology, 1992
To better understand the metastatic behavior of pulmonary adenocarcinoma, we studied the differences in carbohydrate antigens between primary tumors and their metastases using three monoclonal antibodies (FH-2 defining Lewis [Le]x, AH-6 defining Le(y), and FH-6 defining sialyl Le(x-i)) on 56 autopsy cases (including 15 cases in which primary tumors ...
K, Sugiyama, T, Kawai, N, Nagata, M, Suzuki   +3 more
openaire   +2 more sources

Synthesis of non-natural glycosylamino acids containing tumor-associated carbohydrate antigens

Tetrahedron, 2003
Abstract The synthesis of biologically relevant glycosylamino acids using a non-natural amino acid as the glycosyl acceptor is described. The glycosylation reaction of a monosaccharide tri-chloroacetimidate donor with Fmoc- l -hydroxynorleucine benzyl ester provided the α-O-linked product.
Stacy J. Keding, Atsushi Endo, Samuel J. Danishefsky   +2 more
openaire   +1 more source

Immune activation with peptide assemblies carrying Lewis y tumor‐associated carbohydrate antigen

Journal of Peptide Science, 2016
Molecular assemblies varying morphologies in a wide range from spherical micelle, nanosheet, curved sheet, nanotube and vesicle were prepared and loaded with Lewis y (Ley) tumor‐associated carbohydrate antigen on the assembly surface. The molecular assemblies were composed of poly(sarcosine)m‐block‐poly(L‐lactic acid)30 (m = 15 or 50, Lactosome), poly ...
Yuji, Yamazaki, Naoki, Watabe, Hiroaki, Obata, Eri, Hara, Masashi, Ohmae, Shunsaku, Kimura   +5 more
openaire   +2 more sources

Synthesis of Fluorinated Analogues of Tumor-Associated Carbohydrate and Glycopeptide Antigens

Synlett, 2009
Partial structures of tumor-associated mucin glycoproteins are interesting target structures for the development of selective anticancer vaccines. To probe the effect of fluorination on the immunological and metabolic properties of mucin glycopeptides, six novel fluorinated glycosyl-threonine conjugates have been synthesized.
Anja Hoffmann-Röder, Christian Mersch, Sarah Wagner   +2 more
openaire   +1 more source

Aberrant Glycosylation In Tumors And Tumor-Associated Carbohydrate Antigens

1989
Publisher Summary Aberrant glycosylation is the most common phenomenon associated with oncogenic transformation expressed in cell membranes of animal and human cancer cells. Such aberrant structures at the surface membranes may well be effective targets in prevention, diagnosis, and treatment of human cancer.
openaire   +2 more sources

Multivalent antibody fragments with high functional affinity for a tumor-associated carbohydrate antigen.

The Journal of Immunology, 1996
Abstract We report in this work a human-derived self-assembling polypeptide based on the tetramerization domain of the human transcription factor p53, which can be fused to single-chain Fv Ab (scFv) fragments via a long and flexible hinge sequence of human origin, allowing exploitation of the functional affinity increase of binding to a ...
Rheinnecker, M., Hardt, C., Ilag, L., Kufer, P., Gruber, R., Hoess, A., Lupas, A. ; https://orcid.org/0000-0002-1959-4836, Rottenberger, C., Plückthun, A., Pack, P.   +9 more
openaire   +3 more sources