Results 21 to 30 of about 214,753 (272)
Treating cancer as an infectious disease--viral antigens as novel targets for treatment and potential prevention of tumors of viral etiology. [PDF]
PLoS ONE, 2007 Nearly 20% of human cancers worldwide have an infectious etiology with the most prominent examples being hepatitis B and C virus-associated hepatocellular carcinoma and human papilloma virus-associated cervical cancer. There is an urgent need to find new
Xing Guo Wang +6 more
doaj +1 more source
Инфекция и иммунитет, 2021 Age-related macular degeneration (AMD) and central serous chorioretinopathy (CSC) are diseases targeting the posterior segment of the eye that often lead to lowered visual functions. Pathogenesis of such disorders largely remains unclear.
V. V. Neroev +7 more
doaj +1 more source
Pathogens, 2020 The ongoing SARS-CoV-2 pandemic has triggered multiple efforts for serological tests and vaccine development. Most of these tests and vaccines are based on the Spike glycoprotein (S) or the Nucleocapsid (N) viral protein.
Eric Dumonteil, Claudia Herrera
doaj +1 more source
Multiplex RT-PCR amplification of HIV genes to create a completely autologous DC-based immunotherapy for the treatment of HIV infection. [PDF]
PLoS ONE, 2008 BACKGROUND: Effective therapy for HIV-infected individuals remains an unmet medical need. Promising clinical trials with dendritic cell (DC)-based immunotherapy consisting of autologous DC loaded with autologous virus have been reported, however, these ...
Irina Tcherepanova +8 more
doaj +1 more source
Viruses, 2023 The nasal mucosa is the main gateway for entry, replication and elimination of the SARS-CoV-2 virus, the pathogen that causes severe acute respiratory syndrome (COVID-19).
Juliana Costa dos Santos +8 more
doaj +1 more source
Antigenic cooperation in Viral Populations: Transformation of Functions of Intra-Host Viral Variants [PDF]
arXiv, 2022 In this paper we study intra-host viral adaptation by antigenic cooperation - a mechanism of immune escape that serves as an alternative to the standard mechanism of escape by continuous genomic diversification and allows to explain a number of experimental observations associated with the establishment of chronic infections by highly mutable viruses ...
arxiv
HLA and immunodominance in viral infection: T-cell responses in protection and immunopathogenesis [PDF]
Microbiology Australia, 2021 The protective role of T cells in viral infection is well described. T cells generally mediate anti-viral immune responses via direct cytotoxicity and production of pro-inflammatory cytokines, by providing help to B cells and by promotion of memory ...
Suzi McCarthy, Allison Imrie
doaj
Plasmacytoid dendritic cells capture and cross-present viral antigens from influenza-virus exposed cells. [PDF]
PLoS ONE, 2009 Among the different subsets of dendritic cells (DC), plasmacytoid dendritic cells (PDC) play a unique role in secreting large amounts of type I interferons upon viral stimulation, but their efficiency as antigen-presenting cells has not been completely ...
Gabrielle Lui +5 more
doaj +1 more source
From Superantigens to “Real” Viral Antigens [PDF]
Viral Immunology, 2020 Studies inspired by Dr. Peter Doherty led to over 16 years of research into the mouse gamma-herpesvirus, γHV68, in the Blackman laboratory. Progress on our understanding of γHV68 biology include insight into the establishment of latency, immune control of the acute and latent stages of infection and experimental vaccines, is described here.
openaire +3 more sources
Vaccination shapes evolutionary trajectories of SARS-CoV-2 [PDF]
arXiv, 2022 The large-scale evolution of the SARS-CoV-2 virus has been marked by rapid turnover of genetic clades. New variants show intrinsic changes, notably increased transmissibility, as well as antigenic changes that reduce the cross-immunity induced by previous infections or vaccinations.
arxiv