Results 61 to 70 of about 2,011,135 (332)

Innate Viral Receptor Signaling Determines Type 1 Diabetes Onset

Frontiers in Endocrinology, 2017
Heritable susceptibility of the autoimmune disorder, type 1 diabetes (T1D), only partially equates for the incidence of the disease. Significant evidence attributes several environmental stressors, such as vitamin D deficiency, gut microbiome, dietary ...
Zachary J. Morse, Marc S. Horwitz
doaj   +1 more source

Autoradiographic detection of IgG and viral antigens

Journal of Immunological Methods, 1982
Autoradiographic methods can be used as an alternative to indirect immunofluorescence to detect viral antigen expression or the presence of IgG in tissue sections. Iodinated protein A isolated from Staphylococcus aureus detects an influx of IgG into the central nervous system of mice inoculated with the coronavirus SD.
J.C. Gerdes, J.C. Gerdes, L. Hileman, J.S. Burks, J.S. Burks, I. McNally   +5 more
openaire   +3 more sources

Interaction vesicles as emerging mediators of host‐pathogen molecular crosstalk and their implications for infection dynamics

FEBS Letters, EarlyView.
Interaction extracellular vesicles (iEVs) are hybrid vesicles formed through host‐pathogen communication. They facilitate immune evasion, transfer pathogens' molecules, increase host cell uptake, and enhance virulence. This Perspective article illustrates the multifunctional roles of iEVs and highlights their emerging relevance in infection dynamics ...
Bruna Sabatke, Izadora Volpato Rossi, Marcel I. Ramirez   +2 more
wiley   +1 more source

Ebola virus-mediated T-lymphocyte depletion is the result of an abortive infection.

PLoS Pathogens, 2019
Ebola virus (EBOV) infections are characterized by a pronounced lymphopenia that is highly correlative with fatalities. However, the mechanisms leading to T-cell depletion remain largely unknown.
Patrick Younan, Rodrigo I Santos, Palaniappan Ramanathan, Mathieu Iampietro, Andrew Nishida, Mukta Dutta, Tatiana Ammosova, Michelle Meyer, Michael G Katze, Vsevolod L Popov, Sergei Nekhai, Alexander Bukreyev   +11 more
doaj   +1 more source

Modeling viral coevolution: HIV multi-clonal persistence and competition dynamics [PDF]

, 2005
The coexistence of different viral strains (quasispecies) within the same host are nowadays observed for a growing number of viruses, most notably HIV, Marburg and Ebola, but the conditions for the formation and survival of new strains have not yet been ...
Altfeld, Bagnoli, Bello, Blackard, Burch, Celada, Chao, Costa, De Boer, De Boer, Eigen, Eigen, F. Bagnoli, Franz, Galvani, Gerhardt, Gog, Haaft, Ho, Jenkins, Jetzt, Kijak, Krempl, L. Sguanci, Levy, Lin, Lio, Mansky, Miller, Neumann, P. Liò, Pantaleo, Parkin, Perelson, Perelson, Ramos, Revilla, Schnell, Shankarappa, Wei, Wiegel, Wodarz1, Yang, Zanotto   +43 more
core   +2 more sources

Evolutionary interplay between viruses and R‐loops

FEBS Letters, EarlyView.
Viruses interact with specialized nucleic acid structures called R‐loops to influence host transcription, epigenetic states, latency, and immune evasion. This Perspective examines the roles of R‐loops in viral replication, integration, and silencing, and how viruses co‐opt or avoid these structures.
Zsolt Karányi, Zita Képes, Zoltán Szabó, Eszter Csoma, Lóránt Székvölgyi   +4 more
wiley   +1 more source

Diagnosis and management of chronic viral hepatitis: antigens, antibodies and viral genomes. [PDF]

Best Practice & Research Clinical Gastroenterology, 2008
Virological tools, including serological and molecular tools, are needed to diagnose chronic hepatitis B and C infections. They may also be useful to establish their prognosis, but they have found their principal application in guiding treatment decisions and assessing the virological responses to therapy.
S. Chevaliez, J. Pawlotsky
semanticscholar   +4 more sources

Single‐cell insights into the role of T cells in B‐cell malignancies

FEBS Letters, EarlyView.
Single‐cell technologies have transformed our understanding of T cell–tumor cell interactions in B‐cell malignancies, revealing new T‐cell subsets, functional states, and immune evasion mechanisms. This Review synthesizes these findings, highlighting the roles of T cells in pathogenesis, progression, and therapy response, and underscoring their ...
Laura Llaó‐Cid
wiley   +1 more source

Induction of Immune Tolerance to Foreign Protein via Adeno-Associated Viral Vector Gene Transfer in Mid-Gestation Fetal Sheep.

PLoS ONE, 2017
A major limitation to adeno-associated virus (AAV) gene therapy is the generation of host immune responses to viral vector antigens and the transgene product.
Marcus G Davey, John S Riley, Abigail Andrews, Alec Tyminski, Maria Limberis, Jennifer E Pogoriler, Emily Partridge, Aliza Olive, Holly L Hedrick, Alan W Flake, William H Peranteau   +10 more
doaj   +1 more source

Long-lasting cross-protection against influenza A by neuraminidase and M2e-based immunization strategies [PDF]

, 2016
There is mounting evidence that in the absence of neutralizing antibodies cross-reactive T cells provide protection against pandemic influenza viruses. Here, we compared protection and CD8+ T cell responses following challenge with H1N1 2009 pandemic and
Callewaert, Nico, Fiers, Walter, Saelens, Xavier, Schepens, Bert, Schotsaert, Michael, Smet, Anouk, Stegalkina, Svetlana, Vanderschaeghe, Dieter, Vogel, Thorsten U, Ysenbaert, Tine   +9 more
core   +2 more sources