Results 71 to 80 of about 214,753 (272)

Absence of CTL Responses to Early Viral Antigens Facilitates Viral Persistence [PDF]

The Journal of Immunology, 2008
Abstract CD8+ T cells are crucial for the control of intracellular pathogens such as viruses and some bacteria. Using lymphocytic choriomeningitis virus (LCMV) infection of mice—the prototypic arenavirus evolutionarily closely related to human Lassa fever and South American hemorrhagic fever viruses, we have shown previously that the ...
Schildknecht, A, Welti, S, Geuking, M B, Hangartner, L, van den Broek, Maries   +4 more
openaire   +4 more sources

Beyond digital twins: the role of foundation models in enhancing the interpretability of multiomics modalities in precision medicine

FEBS Open Bio, EarlyView.
This review highlights how foundation models enhance predictive healthcare by integrating advanced digital twin modeling with multiomics and biomedical data. This approach supports disease management, risk assessment, and personalized medicine, with the goal of optimizing health outcomes through adaptive, interpretable digital simulations, accessible ...
Sakhaa Alsaedi, Xin Gao, Takashi Gojobori   +2 more
wiley   +1 more source

Mathematical modeling of antigenicity for HIV dynamics [PDF]

MathS In Action 3, 1 (2010) 1-35, 2008
This contribution is devoted to a new model of HIV multiplication motivated by the patent of one of the authors. We take into account the antigenic diversity through what we define "antigenicity", whether of the virus or of the adapted lymphocytes. We model the interaction of the immune system and the viral strains by two processes.
arxiv  

Diagnosis and management of chronic viral hepatitis: Antigens, antibodies and viral genomes [PDF]

Best Practice & Research Clinical Gastroenterology, 2008
Virological tools, including serological and molecular tools, are needed to diagnose chronic hepatitis B and C infections. They may also be useful to establish their prognosis, but they have found their principal application in guiding treatment decisions and assessing the virological responses to therapy.
Chevaliez, Stéphane, Pawlotsky, Jean-Michel   +1 more
openaire   +3 more sources

Hydrogen sulfide repairs testicular damage induced by heat stress in rats

FEBS Open Bio, EarlyView.
Heat stress can cause testicular damage and affect fertility. We investigated the potential protective role of hydrogen sulfide (H2S) against heat stress‐induced testicular injury and observed that H2S donor NaHS can effectively restore testicular damage in rats by inhibiting inflammation and oxidative stress. Our results suggest that H2S might be used
Xinyu Guo, Yupeng Yin, Susu Guo, Xiaoyan Chen, Suyan Xie, Shiqin Chen, Yan Huang   +6 more
wiley   +1 more source

Kinetics of antigen expression and epitope presentation during virus infection.

PLoS Pathogens, 2013
Current knowledge about the dynamics of antigen presentation to T cells during viral infection is very poor despite being of fundamental importance to our understanding of anti-viral immunity.
Nathan P Croft, Stewart A Smith, Yik Chun Wong, Chor Teck Tan, Nadine L Dudek, Inge E A Flesch, Leon C W Lin, David C Tscharke, Anthony W Purcell   +8 more
doaj   +1 more source

Targeting viral antigens to CD11c on dendritic cells induces retrovirus-specific T cell responses. [PDF]

PLoS ONE, 2012
Dendritic cells (DC) represent the most potent antigen presenting cells and induce efficient cytotoxic T lymphocyte (CTL) responses against viral infections.
Asim Ejaz, Christoph G Ammann, Roland Werner, Georg Huber, Verena Oberhauser, Susanne Hörl, Simone Schimmer, Ulf Dittmer, Dorothee von Laer, Heribert Stoiber, Zoltán Bánki   +10 more
doaj   +1 more source

Hemagglutination with Adenoviruses. Nature of Viral Antigen

Experimental Biology and Medicine, 1958
SummaryA rise in antibodies to types 1-4 of adenoviruses during illness can be detected in human serum by employing hemagglutination technics. Although the original method described does not measure an increase in antibodies directed against a single type of virus, type-specific antibodies can be titrated if serum is mixed with a pool of heterologous ...
Harold S. Ginsberg, Eugene Ross
openaire   +3 more sources

Co‐expression of HSV‐1 ICP34.5 enhances the expression of gene delivered by self‐amplifying RNA and mitigates its immunogenicity

FEBS Open Bio, EarlyView.
ICP34.5 is one of the most important antihost response proteins. The saRNA‐encoding HSV‐1 neurovirulence protein ICP34.5 clearly mediated the eukaryotic initiation factor 2 alpha subunit (eIF2α) dephosphorylation and significant suppression of innate immune responses in vitro, leading to enhanced expression of the saRNA‐encoded gene.
Xuemin Lu, Yabin Wu, Chunye Zhao, Jie Zheng, Shangwu Chen, Yigang Wang, Yulong Xia   +6 more
wiley   +1 more source

Long non‐coding RNAs as therapeutic targets in head and neck squamous cell carcinoma and clinical application

FEBS Open Bio, EarlyView.
Long non‐coding RNAs (lncRNAs) occupy an abundant fraction of the eukaryotic transcriptome and an emerging area in cancer research. Regulation by lncRNAs is based on their subcellular localization in HNSCC. This cartoon shows the various functions of lncRNAs in HNSCC discussed in this review.
Ellen T. Tran, Ruchi A. Patel, Amogh Chariyamane, Ratna B. Ray   +3 more
wiley   +1 more source