ICAMs Are Not Obligatory for Functional Immune Synapses between Naive CD4 T Cells and Lymph Node DCs
Cell Reports, 2018 Protective immune responses depend on the formation of immune synapses between T cells and antigen-presenting cells (APCs). The two main LFA-1 ligands, ICAM-1 and ICAM-2, are co-expressed on many cell types, including APCs and blood vessels.
Sara W. Feigelson +12 more
doaj +1 more source
Structure and genetics of Escherichia coli O antigens
FEMS Microbiology Reviews, 2019 Escherichia coli includes clonal groups of both commensal and pathogenic strains, with some of the latter causing serious infectious diseases. O antigen variation is current standard in defining strains for taxonomy and epidemiology, providing the basis ...
B. Liu +9 more
semanticscholar +1 more source
Systematic Chemoenzymatic Synthesis of O-Sulfated Sialyl Lewis x Antigens. [PDF]
, 2015 O-Sulfated sialyl Lewis x antigens play important roles in nature. However, due to their structural complexity, they are not readily accessible by either chemical or enzymatic synthetic processes.
Chen, Xi +8 more
core +1 more source
Targeting self- and foreign antigens to dendritic cells via DC-ASGPR generates IL-10-producing suppressive CD4+ T cells [PDF]
, 2012 Dendritic cells (DCs) can initiate and shape host immune responses toward either immunity or tolerance by their effects on antigen-specific CD4(+) T cells.
Akira +66 more
core +2 more sources
Citrullinated vimentin as an important antigen in immune complexes from synovial fluid of rheumatoid arthritis patients with antibodies against citrullinated proteins [PDF]
, 2010 Introduction: Rheumatoid arthritis (RA) is an inflammatory disease, which results in destruction of the joint. The presence of immune complexes (IC) in serum and synovial fluid of RA patients might contribute to this articular damage through different ...
De Ceuleneer, Marlies +5 more
core +3 more sources
Main features of DNA-based immunization vectors
Brazilian Journal of Medical and Biological Research, 1999 DNA-based immunization has initiated a new era of vaccine research. One of the main goals of gene vaccine development is the control of the levels of expression in vivo for efficient immunization.
V. Azevedo +5 more
doaj +1 more source
Journal of Immunology, 1975 The Cowan I strain of the bacterium Staphylococcus aureus has been used as an adsorbent for antibodies complexed with radiolabeled antigens from cell lysates. This application is advanced as a superior alternative to other methods of immune precipitation
S. Kessler
semanticscholar +1 more source
Regulation of T cell expansion by antigen presentation dynamics [PDF]
PNAS 2019, 116 (13) 5914-5919, 2018 An essential feature of the adaptive immune system is the proliferation of antigen-specific lymphocytes during an immune reaction to form a large pool of effector cells. This proliferation must be regulated to ensure an effective response to infection while avoiding immunopathology.
arxiv +1 more source
CD22: A Regulator of Innate and Adaptive B Cell Responses and Autoimmunity
Frontiers in Immunology, 2018 CD22 (Siglec 2) is a receptor predominantly restricted to B cells. It was initially characterized over 30 years ago and named “CD22” in 1984 at the 2nd International workshop in Boston (1).
Edward A. Clark +2 more
doaj +1 more source
Monoclonal Antibodies against the Drosophila Nervous System [PDF]
, 1982 A panel of 148 monoclonal antibodies directed against Drosophila neural antigens has been prepared by using mice immunized with homogenates of Drosophila tissue. Antibodies were screened immunohistochemically on cryostat sections of fly heads.
Benzer, Seymour +4 more
core +1 more source