Results 21 to 30 of about 1,337,759 (297)

Checkpoint Blockade Cancer Immunotherapy Targets Tumour-Specific Mutant Antigens

Nature, 2014
The immune system influences the fate of developing cancers by not only functioning as a tumour promoter that facilitates cellular transformation, promotes tumour growth and sculpts tumour cell immunogenicity, but also as an extrinsic tumour suppressor ...
M. Gubin, Xiuli Zhang, H. Schuster, E. Caron, J. Ward, T. Noguchi, Yulia Ivanova, J. Hundal, C. Arthur, Willem-Jan Krebber, G. Mulder, M. Toebes, M. Vesely, S. Lam, A. Korman, J. Allison, G. Freeman, A. Sharpe, Erika L. Pearce, T. Schumacher, R. Aebersold, H. Rammensee, C. Melief, E. Mardis, W. Gillanders, M. Artyomov, R. Schreiber   +26 more
semanticscholar   +1 more source

Structure-Guided Redesign Improves NFL HIV Env Trimer Integrity and Identifies an Inter-Protomer Disulfide Permitting Post-Expression Cleavage

Frontiers in Immunology, 2018
Soluble HIV-1 envelope glycoprotein (Env) trimers are under active investigation as vaccine candidates in relevant pre-clinical models. Like SOSIPs, the cleavage-independent native flexibly linked (NFL) trimers are faithful mimics of the Env spike. Here,
Lifei Yang, Shailendra Kumar Sharma, Christopher Cottrell, Javier Guenaga, Karen Tran, Richard Wilson, Anna-Janina Behrens, Max Crispin, Max Crispin, Max Crispin, Natalia de Val, Richard T. Wyatt, Richard T. Wyatt, Richard T. Wyatt   +13 more
doaj   +1 more source

THE BIOTIC FACTOR OF TREMATOD OPISTHORHIS FELINEUS INVASION INFLUENCE ON HOST IMMUNE STATUS AND SOMATIC CELLS PROLIFERATIVE ACTIVITY

Инфекция и иммунитет, 2016
The paper confirms long-time opisthorhis invasion role as a risk factor of host immune system reconstitution as well as an important factor in holangiocarcinomas development. It was shown that opisthorhosis invasion primal stage induce host immune system
A. G. Rybka
doaj   +1 more source

Verificación del desempeño de la prueba rápida "AMP Rapid Test SARS-CoV-2 IgG/IgM- Cassettes"

Infectio, 2021
Objective: We aimed to realize a verification of the performance of the rapid serological tests used in Risaralda department.Methods: Analytical, cross-sectional study.
Diana María Gil-Villa
doaj   +1 more source

CD22: A Regulator of Innate and Adaptive B Cell Responses and Autoimmunity

Frontiers in Immunology, 2018
CD22 (Siglec 2) is a receptor predominantly restricted to B cells. It was initially characterized over 30 years ago and named “CD22” in 1984 at the 2nd International workshop in Boston (1).
Edward A. Clark, Edward A. Clark, Natalia V. Giltiay   +2 more
doaj   +1 more source

Structure and genetics of Escherichia coli O antigens

FEMS Microbiology Reviews, 2019
Escherichia coli includes clonal groups of both commensal and pathogenic strains, with some of the latter causing serious infectious diseases. O antigen variation is current standard in defining strains for taxonomy and epidemiology, providing the basis ...
B. Liu, Axel Furevi, A. Perepelov, Xi Guo, Hengchun Cao, Quan Wang, P. Reeves, Y. Knirel, Lei Wang, G. Widmalm   +9 more
semanticscholar   +1 more source

ICAMs Are Not Obligatory for Functional Immune Synapses between Naive CD4 T Cells and Lymph Node DCs

Cell Reports, 2018
Protective immune responses depend on the formation of immune synapses between T cells and antigen-presenting cells (APCs). The two main LFA-1 ligands, ICAM-1 and ICAM-2, are co-expressed on many cell types, including APCs and blood vessels.
Sara W. Feigelson, Adam Solomon, Adi Biram, Miki Hatzav, Moria Lichtenstein, Ofer Regev, Stav Kozlovski, Diana Varol, Caterina Curato, Dena Leshkowitz, Steffen Jung, Ziv Shulman, Ronen Alon   +12 more
doaj   +1 more source

Increased levels of invariant natural killer T lymphocytes worsen metabolic abnormalities and atherosclerosis in obese mice

Journal of Lipid Research, 2013
Obesity is a chronic inflammatory state characterized by infiltration of adipose tissue by immune cell populations, including T lymphocytes. Natural killer T (NKT) cells, a specialized lymphocyte subset recognizing lipid antigens, can be pro- or anti ...
Savitha Subramanian, Michael S. Turner, Yilei Ding, Leela Goodspeed, Shari Wang, Jane H. Buckner, Kevin O'Brien, Godfrey S. Getz, Catherine A. Reardon, Alan Chait   +9 more
doaj   +1 more source

Human Vaccines in India: Present and Future Perspectives

MGM Journal of Medical Sciences, 2019
Vaccines are formulations that equip the human immune system to fight against a pathogen. All the vaccines approved for use are safe. On vaccination, the body produces enough clonal B and T cells to resist infection.
Prasanta Kumar Ghosh
doaj   +1 more source

Rapid isolation of antigens from cells with a staphylococcal protein A-antibody adsorbent: parameters of the interaction of antibody-antigen complexes with protein A.

Journal of Immunology, 1975
The Cowan I strain of the bacterium Staphylococcus aureus has been used as an adsorbent for antibodies complexed with radiolabeled antigens from cell lysates. This application is advanced as a superior alternative to other methods of immune precipitation
S. Kessler
semanticscholar   +1 more source