Results 81 to 90 of about 6,856 (183)

Synthesis, characterization, in silico and in vitro studies of novel glycoconjugates as potential antibacterial, antifungal, and antileishmanial agents

Open Chemistry
In the present work, several new glycoconjugates (8a–e) were generated from glycopyranosyl-α-trichloroacetimidates (sugar-OTCA) as glycosyl donors and dimethyl-l-tartrate as an aglycone acceptor in good to excellent yields.
Khan Sher Wali, Nayab Saira, Umar Muhammad Naveed, Khan Momin, Iqbal Anila, Ahmad Nasir, Rashid Haroon ur, Shah Muhammad Ishaq Ali, Gulfam Naila, Zahoor Muhammad, Ullah Riaz, Ali Essam A.   +11 more
doaj   +1 more source

Biological Evaluation of 3-Aryl and/or 4-(N-Aryl)aminocoumarins Against Human Pathogens: Antileishmanial and Antiviral Activities

Future Pharmacology
Background: Vector-borne diseases, such as leishmaniasis and arboviral infections, represent a great challenge to human health with limited therapeutic options.
Vitor Won-Held Rabelo, Leonardo Simões de Abreu Carneiro, Luan Letieri Belem Martins, Fernando Almeida-Souza, Luciene Soares Silva, Leonardo dos Santos Corrêa Amorim, Maria Leonisa Sanchez-Nuñez, Kátia da Silva Calabrese, Paula Alvarez Abreu, Camilla Djenne Buarque, Izabel Christina Nunes de Palmer Paixão   +10 more
doaj   +1 more source

In Vitro Antileishmanial Activity and GC-MS Analysis of Whole Plant Hexane Fraction of Achillea wilhelmsii (WHFAW)

Journal of Chemistry, 2019
In this study, GC-MS analysis has shown that whole plant hexane fraction of Achillea wilhelmsii (WHFAW) consists of 66 compounds which exhibited antileishmanial activity.
Jahangir Khan Achakzai, Muhammad Anwar Panezai, Abdul Manan Kakar, Basira Akhtar, Ali Akbar, Shahabuddin Kakar, Javed Khan, Nazima Yousaf Khan, Ghulam Mustafa Khan, Nizam Baloch, Muhammad Hashim Jan Khoso, Marina Panezai   +11 more
doaj   +1 more source

Antileishmanial and Antitoxoplasmal Activities of 1,4-dihydropyridines

ACS Omega
Abstract: We have synthesized 24 1,4-dihydropyridine compounds (1,4-DHPs) with different substituents at the aromatic ring by microwave-assisted one-pot Hantzsch multicomponent reac-tion and evaluated their in vitro activities against Toxoplasma gondii and Leishmania major.
Thaís Oliveira, Yan Robles, Ibrahim Al Nasr, Waleed Koko, Tariq Khan, Ismail Daoud, Seyfeddine Rahali, Noureddine Amdouni, Ridha Ben Said, Antônio Crotti   +9 more
openaire   +3 more sources

Evaluation of Antileishmanial and Antibacterial Activity of Bioconjugate Guanidine–Temporin

Pharmaceuticals
Background: Peptides are promising tools in medicine for viral, bacterial, and parasitic infections. MAP1 and MAP2 are peptides with antimicrobial activity.
Gabriel Antunes Santoro, Natalia Caroline Souza Costa, Sarah Tolentino Rocha Brandão, Jhonatan Santos de Lima, Angela Maria Arenas Velasquez, Luana Ribeiro dos Anjos, Cauã Dias Abrão, João Victor Marcelino de Souza, Marcela Nunes Argentin, Ilana Lopes Baratella da Cunha Camargo, Marcia A. S. Graminha, Eduardo Rene P. Gonzalez, Eduardo Maffud Cilli   +12 more
doaj   +1 more source

Cross-Species Hepatic Metabolism of the Antileishmanial Chalcone NAT22 Generates Metabolites with Predicted Enhanced Affinity for the Parasite Target cTXNPx. [PDF]

Pharmaceutics
Barreto ARR, Valente APC, Schaeffer E, de Almeida VM, Muzitano MF, Barth T, de Souza AMT, de A A Vieira B, da Silva AM, Santos-Filho OA, Steel PG, Rossi-Bergmann B.   +11 more
europepmc   +1 more source

Antileishmanial Activity of <i>Schinus terebinthifolia</i> Essential Oil: Chemistry, In Vitro and Mechanistic Studies. [PDF]

Molecules
Monzote L, Betancourt L, Scull R, Satyal P, Gil L, Gille L, Setzer WN.   +6 more
europepmc   +1 more source

Eprinomectin Inhibits <i>Leishmania</i> by Inducing Mitochondrial Dysfunction and Cell Cycle Arrest. [PDF]

Transbound Emerg Dis
Yu M, Guo J, Liu W, Li Y.
europepmc   +1 more source

Harnessing nature: a systematic exploration of <i>in vitro</i> antileishmanial and antihuman African trypanosomal properties in traditional medicinal plants and their active principles. [PDF]

Pharm Biol
Ahmed QU, Mat Nasir NA, Begum T, Helal Uddin ABM, Parveen H, Albalawi MO, Ali Khan Khattak MM, Azmi SNH, Sarian MN, Kurniawati AD, Zakaria ZA.   +10 more
europepmc   +1 more source

Machine Learning-Based QSAR Models for Discovery of Inhibitors Targeting <i>Leishmania infantum</i> Amastigotes. [PDF]

Pharmaceuticals (Basel)
Flores-Balmaseda N, Rojas-Vargas JA, Rojas-Socarrás S, Pérez-Giménez F, Torrens F, Castillo-Garit JA.   +5 more
europepmc   +1 more source