Results 1 to 10 of about 51,125 (324)
Marine Drugs, 2009 Malaria is an infectious disease causing at least 1 million deaths per year, and, unfortunately, the chemical entities available to treat malaria are still too limited. In this review we highlight the contribution of marine chemistry in the field of antimalarial research by reporting the most important results obtained until the beginning of 2009, with
FATTORUSSO, ERNESTO +1 more
openaire +5 more sources
On peroxide antimalarials [PDF]
Journal of the Serbian Chemical Society, 2007 Several dicyclohexylidene tetraoxanes were prepared in order to gain a further insight into structure-activity relationship of this kind of antimalarials. The tetraoxanes 2-5, obtained as a cis/trans mixture, showed pronounced antimalarial activity against Plasmodium falciparum chloroquine susceptible D6, chloroquine resistant W2 and multidrug ...
Igor Opsenica +6 more
openaire +5 more sources
Hydroxychloroquine and Antimalarials [PDF]
The Journal of Rheumatology, 2019 We read the editorial by Sandhu, et al1 about antimalarial-induced cardiomyopathy in systemic lupus erythematosus2, and we want to point out some inaccuracies in the brief review of the history of antimalarials that they presented.
LUIS CAMINAL-MONTERO +1 more
openaire +3 more sources
Journal of the Serbian Chemical Society, 2009 The problem of endemic malaria continues unabated globally. Malaria affects 40 % of the global population, causing an estimated annual mortality of 1.5-2.7 million people. The World Health Organization (WHO) estimates that 90 % of these deaths occur in sub-Saharan Africa among infants under the age of five.
Dejan Opsenica, Bogdan Solaja
openaire +4 more sources
Antimalarial drug resistance [PDF]
Journal of Clinical Investigation, 2004 Malaria, the most prevalent and most pernicious parasitic disease of humans, is estimated to kill between one and two million people, mainly children, each year. Resistance has emerged to all classes of antimalarial drugs except the artemisinins and is responsible for a recent increase in malaria-related mortality, particularly in Africa.
openaire +5 more sources
Cardiotoxicity of antimalarial drugs [PDF]
The Lancet Infectious Diseases, 2007 There are consistent differences in cardiovascular state between acute illness in malaria and recovery that prolong the electrocardiographic QT interval and have been misinterpreted as resulting from antimalarial cardiotoxicity. Of the different classes of antimalarial drugs, only the quinolines, and structurally related antimalarial drugs, have ...
Nicholas J. White, Nicholas J. White
openaire +3 more sources
Advances in Antimalarial Drug Evaluation and New Targets for Antimalarials [PDF]
, 2012 Parasitic infections due to the protozoa Plasmodium are responsible for malaria, a severe disease that still caused about 225 million cases and 781,000 human deaths in 2009, despite the efforts developed during the last decade to fight this disease (Alonso et al., 2011).
Grellier, Philippe +2 more
openaire +5 more sources
Antimalarial Activity of Piperine
Journal of Tropical Medicine, 2018 Malaria remains a public health problem in tropical and subtropical regions. Resistance of Plasmodium falciparum to artemisinins in Southeast Asia is a great concern for disease control and research on discovery and development of new alternative antimalarial drugs is urgently required. In a previous study, the fruit of Piper chaba Hunt.
Artitaya Thiengsusuk +3 more
openaire +3 more sources
Antiretrovirals as Antimalarial Agents [PDF]
The Journal of Infectious Diseases, 2004 Recent studies have indicated that antiretroviral protease inhibitors may affect outcome in malarial disease. We have investigated the antimalarial activities of 6 commonly used antiretroviral agents. Our data indicate that, in addition to the previously published effects on cytoadherence and phagocytosis, the human immunodeficiency virus (HIV)-1 ...
Tina S. Skinner-Adams +5 more
openaire +4 more sources
Discovering Antimalarials [PDF]
Chemistry & Biology, 2002 Recent discoveries have uncovered some key processes that occur in the food vacuole of the malarial parasite. Consequently, new families of potential antimalarials that inhibit HRP-2, a hitherto unexplored drug target, were identified using a novel screening method.
openaire +3 more sources