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Marine Drugs, 2009 Malaria is an infectious disease causing at least 1 million deaths per year, and, unfortunately, the chemical entities available to treat malaria are still too limited. In this review we highlight the contribution of marine chemistry in the field of antimalarial research by reporting the most important results obtained until the beginning of 2009, with
FATTORUSSO, ERNESTO +1 more
openaire +5 more sources
PLoS ONE, 2013 BackgroundDevelopment of resistance to first line antimalarials led to recommendation of artemisinin based combination therapies (ACTs). High adherence to ACTs provided by community health workers (CHWs) gave reassurance that community based ...
Elizeus Rutebemberwa, Sarah N Ssali
exaly +3 more sources
Polymeric Nanocarriers for the Delivery of Antimalarials
Molecules, 2018 Malaria is an infectious disease caused by a protozoan parasite which is transmitted by female Anopheles mosquitoes around tropical and sub-tropical regions. Half of the world’s population is at risk of being infected by malaria.
Blessing A Aderibigbe
exaly +3 more sources
Evaluation of In-Hospital Management for Febrile Illness\ud in Northern Tanzania before and after 2010 World Health\ud Organization Guidelines for the Treatment of Malaria [PDF]
, 2014 In 2010, the World Health Organization (WHO) published updated guidelines emphasizing and expanding recommendations for a parasitological confirmation of malaria before treating with antimalarials. This study aimed to assess differences in historic (2007–
Biggs, Holly M. +6 more
core +30 more sources
The Ototoxicity of Antimalarial Drugs—A State of the Art Review
Frontiers in Neurology, 2021 This review summarizes current knowledge about the occurrence of hearing and balance disorders after antimalarial drugs treatment. It also examines the clinical applications of antimalarials, their mechanisms behind this ototoxicity and how it can be ...
Magdalena Jozefowicz-Korczynska +2 more
doaj +1 more source
Frontiers in Pharmacology, 2021 Malaria is an endemic disease that affected 229 million people and caused 409 thousand deaths, in 2019. Disease control is based on early diagnosis and specific treatment with antimalarial drugs since no effective vaccines are commercially available to ...
Isabela P. Ceravolo +3 more
doaj +1 more source
Molecules, 2022 Malaria chemotherapy is greatly threatened by the recent emergence and spread of resistance in the Plasmodium falciparum parasite against artemisinins and their partner drugs. Therefore, it is an urgent priority to develop new antimalarials. Plasmepsin V
Xin Ji +6 more
doaj +1 more source
Pharmaceuticals, 2021 Plasmodium spp. malaria parasites in the blood stage draw energy from anaerobic glycolysis when multiplying in erythrocytes. They tap the ample glucose supply of the infected host using the erythrocyte glucose transporter 1, GLUT1, and a hexose ...
Cornelius Nerlich +3 more
doaj +1 more source
New 4-aminoquinolines as moderate inhibitors of P. falciparum malaria [PDF]
Journal of the Serbian Chemical Society, 2021 Synthesis of novel aminoquinoline derivatives has been accomplished and their activity against malaria strains has been examined. The compounds showed moderate in vitro antimalarial activity against two P.
Opsenica Igor +7 more
doaj +1 more source
Pioneer Use of Antimalarial Transdermal Combination Therapy in Rodent Malaria Model
Pathogens, 2023 We have previously reported 1,2,6,7-tetraoxaspiro [7.11]nonadecane (N-89) as a promising antimalarial compound. In this study, we evaluated the effect of transdermal therapy (tdt) of N-89 in combination (tdct) with other antimalarials as an application ...
Nagwa S. M. Aly +8 more
doaj +1 more source