Results 101 to 110 of about 37,913 (268)

Artemisinin-Based Combination Therapies in East Africa: A Systematic Review of Quality, Clinical Efficacy, and Regulatory Progress Towards Sustainable Malaria Control. [PDF]

Trop Med Int Health
ABSTRACT Background Malaria is a major public health issue in East Africa, leading to widespread illness and fatalities, especially among vulnerable populations such as children under 5 years of age and pregnant women. Artemisinin‐based combination therapies (ACTs) are the primary treatment modality; however, their efficacy is undermined by the ...
Mekasha YT, Tegegne AA, Mashe T, Girma M, Hasen G, Belew S.   +5 more
europepmc   +2 more sources

Successful Use of Bimekizumab in Refractory Acute Generalised Exanthematous Pustulosis Triggered by Amoxicillin‐Clavulanate

JEADV Clinical Practice, EarlyView.
ABSTRACT Acute generalised exanthematous pustulosis (AGEP) is a rare, acute neutrophilic dermatosis most commonly triggered by drugs, which typically resolves within 2 weeks following withdrawal of the causative agent. Topical and systemic corticosteroids remain the standard treatment.
Alexandra Junge, Charlotte Vogel, Theresa Hempel, Basil Signer, Nikhil Yawalkar, Kristine Heidemeyer   +5 more
wiley   +1 more source

The silent burden of anaemia in Tanzania children:a community-based study [PDF]

, 2003
Objective was to document the prevalence, age-distribution, and risk factors for anaemia in Tanzanian children less than 5 years old,thereby assisting in the development of effective strategies for controlling anaemia.\ud \ud Cluster sampling was used to
Armstrong Schellenberg, J R M, Mbuya, C, Mgalula, L, Mushi, A, Savigny de, D, Schellenberg, D, Victoria, C.G.   +6 more
core   +1 more source

Prevalence, Determinants, and Outcomes of Low Disease Activity and Remission Attainment in Patients With Systemic Lupus Erythematosus That Is Clinically Active. [PDF]

Arthritis Care Res (Hoboken)
Objective This study aimed to identify in patients with systemic lupus erythematosus (SLE) with clinically active disease the attainment of frequency and determinants of Lupus Low Disease Activity State (LLDAS) and Definition of Remission in SLE (DORIS) and the frequency and determinants of flare and damage accrual after target attainment.
Hao Y, Hansen D, Kandane-Rathnayake R, Louthrenoo W, Chen YH, Cho J, Lateef A, Hamijoyo L, Luo SF, Wu YJ, Navarra S, Zamora L, Li Z, Sockalingam S, Katsumata Y, Harigai M, Zhang Z, Chan M, Kikuchi J, Takeuchi T, Bae SC, Goldblatt F, O'Neill S, Ng KPL, Law A, Basnayake BMDB, Tugnet N, Kumar S, Tee C, Tee M, Ohkubo N, Tanaka Y, Chan S, Lau CS, Golder V, Hoi A, Oon S, Morand E, Nikpour M, Asia‐Pacific Lupus Collaboration.   +39 more
europepmc   +2 more sources

Comprehensive Insights into Natural Bioactive Compounds: From Chemical Diversity and Mechanisms to Biotechnological Innovations and Applications

ChemistryOpen, EarlyView.
Natural products derived from plants, animals, fungi, bacteria, and minerals contain diverse bioactive classes such as alkaloids, flavonoids, terpenoids, saponins, tannins, and phenolics. These natural products work through different mechanisms, including ROS inhibition, NF‐κB suppression, and cytokine regulation, and exhibit wide applications across ...
Sajid Ali, Atif Ali Khan Khalil, Muhammad Saeed Akhtar, Adnan Amin, Wajid Zaman   +4 more
wiley   +1 more source

Antimaláricos e Ototoxicidade Antimalarials and Ototoxicity

Revista Brasileira de Reumatologia, 2004
Os antimaláricos, como o difosfato de cloroquina, têm sido usados amplamente no tratamento não só da malária, mas também de doenças reumatológicas como a síndrome de Sjögren (SS), artrite reumatóide (AR) e lúpus eritematoso sistêmico (LES).
Marcelo Cardoso Figueiredo, Ciríaco Cristóvão C. T. Atherino, Clarice Viana Monteiro, Roger Abramino Levy   +3 more
doaj   +1 more source

Efficient One‐Pot Synthesis of Benzothiazole Compounds From Vinamidinium Salts

ChemistryOpen, EarlyView.
A catalyst‐free one‐pot reaction of vinamidinium salts with benzothiazole hydrazines efficiently produces 1,3‐bis((3‐methylbenzo[d]thiazol‐2(3H)‐ylidene)hydrazineylidene)propan‐2‐ol (BBTA) and 1‐((1Z,3E)‐1‐(dimethylamino)‐3‐(((Z)‐3‐methylbenzo[d]thiazol‐2(3H)‐ylidene)hydrazineylidene)prop‐1‐en‐2‐yl)pyridin‐1‐ium (DMBT) derivatives.This simple method ...
Zeinab khosravi, Abdolmohammad Mehranpour, Mohammad Reza Mohammadizadeh, Genta Kojya, Satoru Arimitsuc   +4 more
wiley   +1 more source

Antimalarials and the eye [PDF]

, 1989
Following the first reports in 1954 of the beneficial effects of chloroquine in cases of lupus erythematosus, this drug and its numerous derivatives have been used extensively in the treatment of systemic and discoid lupus erythematosus and rheumatoid ...
Coleiro, Joseph A.
core  

Antimalarial drug resistance [PDF]

Journal of Clinical Investigation, 2004
Malaria, the most prevalent and most pernicious parasitic disease of humans, is estimated to kill between one and two million people, mainly children, each year. Resistance has emerged to all classes of antimalarial drugs except the artemisinins and is responsible for a recent increase in malaria-related mortality, particularly in Africa.
openaire   +4 more sources

Advancing pharmacometrics in Africa—Transition from capacity development toward job creation

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 407-419, March 2025.
Abstract Trained pharmacometricians remain scarce in Africa due to limited training opportunities, lack of a pharmaceutical product development ecosystem, and emigration to high‐income countries. The Applied Pharmacometrics Training (APT) fellowship program was established to address these gaps and specifically foster job creation for talent retention.
Goonaseelan (Colin) Pillai, Samer Mouksassi, Innocent G. Asiimwe, Craig R. Rayner, Steven Kern, Phumla Sinxadi, Paolo Denti, Eric Decloedt, Catriona Waitt, Bernhards R. Ogutu, Rik de Greef   +10 more
wiley   +1 more source