Results 101 to 110 of about 51,125 (324)

Advances in Mechanochemical C─H Functionalization: A Comparative Study with Solvent‐Based Approaches

ChemCatChem, EarlyView.
This review presents the latest advancements made in mechanochemical transition metal catalyzed C─H functionalization, comparing its efficiency, sustainability and scope with traditional solvent‐based methods. By offering a side‐by‐side comparison, it equips organic chemists with the insights needed to select the most effective approach for ...
Nanditha Kattukudiyil Narayanan, Michael Schnürch   +1 more
wiley   +1 more source

Predictors of Antibiotics Co-prescription with Antimalarials for Patients Presenting with Fever in Rural Tanzania. [PDF]

, 2013
Successful implementation of malaria treatment policy depends on the prescription practices for patients with malaria. This paper describes prescription patterns and assesses factors associated with co-prescription of antibiotics and artemether ...
A Mannan, Alexander N Dodoo, ANO Dodoo, B Ahsan, BK Abuaku, BP Mmbando, Brown Kigahe, C Watsierah, CIR Chandler, CIR Chandler, D Zurovac, Dan Kajungu, EME Van Bijnen, F Font, F Font, H Reyburn, H Reyburn, H Riaz, I Masanja, I Tamuno, Ifakara, IM Masanja, Irene Masanja, JR Torvi, JU Okebe, K Bashrahil, K Shamshy, KA Oshikoya, LEG Mboera, Majige Selemani, Mbaraka Amuri, MI Masanja, ML McMorrow, ML Mcmorrow, Mustafa Njozi, Mwageni, N Nshakira, National Malaria Control Programe (NMCP) [Tanania], National Malaria Control Programme (NMCP) [Tanzania], P Winskill, Rashid Khatib, Salim Abdula, TO Ogungbamigbe, VA Badar   +43 more
core   +2 more sources

Cell-Cycle-Associated Amplified Genomic-DNA Fragments (CAGFs) Might Be Involved in Chloroquine Action and Resistance in Plasmodium falciparum [PDF]

arXiv, 2017
As a cheap and safe antimalarial agent, chloroquine (CQ) has been used in the battle against malaria for more than half century. However, the mechanism of CQ action and resistance in Plasmodium falciparum remains elusive. Based on further analysis of our published experimental results, we propose that the mechanism of CQ action and resistance might be ...
arxiv  

Hybrid Molecules as Efficient Drugs against Multidrug‐Resistant Malaria Parasites

ChemMedChem, EarlyView.
Among hybrid molecules currently developed as antimalarial drug candidates, emoquine‐1 exhibits high activity against all the multidrug‐resistant Plasmodium strains tested up to now, including artemisinin‐resistant quiescent parasites, critical parameters for promising antimalarial drugs. It is also curative in mouse malaria.
Anne Robert, Lucie Paloque, Jean‐Michel Augereau, Flore Nardella, Michel Nguyen, Bernard Meunier, Françoise Benoit‐Vical   +6 more
wiley   +1 more source

Novel quinazolinones active against multidrug‐resistant Mycobacterium tuberculosis: synthesis, antimicrobial evaluation and in silico exploration of PonA1 as a potential target

ChemMedChem, Accepted Article.
Quinazolinone derivatives have emerged as promising scaffolds in antimicrobial drug discovery. This work focuses on the design, synthesis, and evaluation of novel quinazolinone‐based compounds and predicts their potential to interact with mycobacterial penicillin‐binding proteins (PBPs).
MAREK KERDA, Daria Nawrot, Petr Slechta, Mirek Domanský, Asal Askari, Hanieh Kamangar, Ondřej Janďourek, Klára Konečná, Pavla Paterová, Ingrid Hlbočanová, Miloslav Macháček, Matteo Mori, Fiorella Meneghetti, Martin Doležal, Jan Zitko, Ghada Bouz   +15 more
wiley   +1 more source

A rare case of melanosis of the hard palate mucosa in a patient with chronic myeloid leukemia [PDF]

, 2015
Imatinib Mesylate, also known as Gleevec or ST1-571, is a tyrosine-kinase inhibitor used as the gold standard medication for the chronic myeloid leukemia (CML); Imatinib has indeed deeply revolutionized the CML therapy allowing most patients to have a ...
Bosco, Daniela, Fantozzi, Paolo Junior, Palaia, Gaspare, Romeo, Umberto, Tenore, Gianluca   +4 more
core   +3 more sources

Nucleus may be the key site of chloroquine antimalarial action and resistance development [PDF]

arXiv, 2017
The first proposed hypothesis about the mechanism of chloroquine (CQ) action on malaria parasites is DNA intercalation hypothesis which indicates that the site of CQ action is within the nucleus. Later on the interest of research was shifted from nucleus to lysosome due to the report of CQ accumulation within lysosome.
arxiv  

Comparative Computational Study on the Robinson–Gabriel Synthesis and Bischler–Napieralski Reaction: Density Functional Theory Investigation of T3P‐Mediated Ring Closure

European Journal of Organic Chemistry, EarlyView.
The detailed comparison of the Bischler–Napieralski and Robinson–Gabriel reactions of tryptamides using propylphosphonic anhydride (T3P) that leads to different products in case of a small change in the substrate is provided. The computed mechanistic pathways explain why the oxoalkyl tryptamide derivative selectively reacts in a Robinson–Gabriel ...
Patrik Pollák, Mátyás Milen, Balázs Volk, Péter Ábrányi‐Balogh   +3 more
wiley   +1 more source

Antimaláricos e perfil lipídico em pacientes com lúpus eritematoso sistêmico Antimalarials and cholesterol profile of patients with systemic lupus erythematosus

Revista Brasileira de Reumatologia, 2011
Recentemente, vem-se atribuindo uma influência benéfica dos antimaláricos no perfil lipídico de pacientes com lúpus eritematoso sistêmico (LES). Neste estudo transversal, avaliamos o efeito da cloroquina nos níveis de colesterol de uma população ...
Carina Rossoni, Melissa Cláudia Bisi, Mauro Waldemar Keiserman, Henrique Luiz Staub   +3 more
doaj   +1 more source

Terpenes and Terpenoids: How can we use them?

European Journal of Organic Chemistry, EarlyView.
The transition from petroleum‐based to renewable bio‐based chemicals has led to increased interest in terpenes and terpenoids. This overview highlights their chemistry, focusing on their reactivity and applications in polymerizations, total syntheses, pharmaceuticals, and bio‐based chemical conversions; promoting sustainable and green chemical ...
Jay Hanssens, Diego Meneses, Jordy M. Saya, Romano V. A. Orru   +3 more
wiley   +1 more source