Results 101 to 110 of about 54,267 (309)

Amazonian Plant Natural Products: Perspectives for Discovery of New Antimalarial Drug Leads

Molecules, 2013
Plasmodium falciparum and P. vivax malaria parasites are now resistant, or showing signs of resistance, to most drugs used in therapy. Novel chemical entities that exhibit new mechanisms of antiplasmodial action are needed.
Lucio H. Freitas-Junior, Pedro Cravo, Marcus Vinícius Guimarães Lacerda, André Machado Siqueira, Carolina Borsoi Moraes, Gina Frausin, Luiz Francisco Rocha e Silva, Stefanie Costa Pinto Lopes, Renata Braga Souza Lima, Fabio Trindade Maranhão Costa, Adrian Martin Pohlit   +10 more
doaj   +1 more source

Insecticide-treated bednets for the prevention of Plasmodium falciparum malaria in Cambodia: a cluster-randomized trial.

, 2006
OBJECTIVES: To validate and quantify the impact of insecticide-treated bednets (ITN) on malaria morbidity and mortality in Cambodia. METHODS: A paired, cluster-randomized trial of ITN was conducted in Rattanakiri, North East Cambodia.
Alexander, N, Hewitt, S, Nguon, C, Okell, L, Rowland, M, Sochantha, T, Socheat, D, Vannara, H, Yeung, S   +8 more
core   +1 more source

Factors Associated with Severe Disease from Malaria, Pneumonia and Diarrhea among Children in Rural Tanzania - a Hospital-Based Cross-Sectional Study. [PDF]

, 2012
Mild cases of malaria, pneumonia and diarrhea are readily treatable with complete recovery and with inexpensive and widely available first-line drugs. However, treatment is complicated and expensive, and mortality is higher when children present to the ...
Hinderaker, Sven Gudmund, Kahabuka, Catherine, Kvåle, Gunnar   +2 more
core   +2 more sources

Clinical pharmacology and prescribing education: An updated medical school curriculum from the British Pharmacological Society

British Journal of Clinical Pharmacology, EarlyView.
Aims Prescribing is a complex, essential skill that doctors must acquire to practice medicine safely and effectively. The British Pharmacological Society has historically provided a core curriculum to guide clinical pharmacology and prescribing education in UK medical schools.
Dagan O. Lonsdale, Clare Guilding, Jennifer Koenig, Michael Okorie, Reecha Sofat, Simon Maxwell   +5 more
wiley   +1 more source

Chloroquine and hydroxychloroquine are associated with reduced cardiovascular risk: a systematic review and meta-analysis

Drug Design, Development and Therapy, 2018
Dan Liu,1,* Xiaodan Li,2,* Yonggang Zhang,3 Joey Sum-Wing Kwong,4,5 Ling Li,6 Yiyi Zhang,1 Chang Xu,6 Qianrui Li,1 Xin Sun,6 Haoming Tian,1 Sheyu Li1,7 1Department of Endocrinology and Metabolism, West China Hospital, Sichuan University, Chengdu 610041,
Liu D, Li X, Zhang Y, Kwong JSW, Li L, Zhang Y, Xu C, Li Q, Sun X, Tian H, Li S   +10 more
doaj  

Relapses of Plasmodium vivax infection usually result from activation of heterologous hypnozoites. [PDF]

, 2007
BACKGROUND: Relapses originating from hypnozoites are characteristic of Plasmodium vivax infections. Thus, reappearance of parasitemia after treatment can result from relapse, recrudescence, or reinfection.
Anderson, T J C, Carlton, J, Day, N P J, Guthmann, J P, Imwong, M, Kim, J R, Looareesuwan, S, Nair, S, Nandy, A, Nosten, F, Pukrittayakamee, S, Snounou, G, Sudimack, D, Tanomsing, N, White, N J   +14 more
core   +2 more sources

The power of many: when genetics met yeasts and high‐throughput

Biological Reviews, EarlyView.
ABSTRACT In recent years, complex technological capabilities have evolved, driven by the need to solve complex and integrative biological questions through global analyses. New equipment allows the scaling up and automation of processes which previously were carried out on a very limited scale.
Víctor A. Tallada, Víctor Carranco
wiley   +1 more source

Identification of Natural Isonitriles Through Ligation to an Azomethine Imine Probe

Chemistry – A European Journal, EarlyView.
The azomethine imine (AMI)–isonitrile (NC) ligation allowed for the chemoselective detection of natural isonitriles in bacteria and fungi. The reactivity‐based screening establishes a new stereogenic center, thereby allowing for facile distinction between chiral and achiral isonitriles. The work also unraveled a unique reactivity of isonitriles bearing
Maurice P. Biedermann, Alexander Brachmann, Shurui Mai, Athanasios Markos, Markus Künzler, Jörn Piel, Helma Wennemers   +6 more
wiley   +1 more source

Advancing Maternal Health with Long‐Acting Therapeutics: Priorities, Efficacy and Safety Considerations, and Emerging Technologies

Clinical Pharmacology &Therapeutics, EarlyView.
Maternal health remains a critical global concern, particularly in underserved populations and in low‐ and middle‐income countries where access to safe and effective therapeutics is limited. Despite the use of medications by most women during pregnancy, the exclusion of pregnant and lactating women from clinical trials has resulted in significant data ...
Rachel K. Scott, Sharon Nachman, Ethel D. Weld, Rachel Daley, Shakir Atoyebi, Robert Bies, Catriona Waitt, Adeniyi Olagunju   +7 more
wiley   +1 more source

In Vitro Antimalarial Activity and Phytochemical Analysis of Aerial Parts of Artemisia fragrans Willd. [PDF]

, 2022
Pegah Akbari, Solmaz Asnaashari, Yahya Rahimpour, Parina Asgharian   +3 more
openalex   +1 more source