Results 111 to 120 of about 91,276 (376)

Mutations in the P-Type Cation-Transporter ATPase 4, PfATP4, Mediate Resistance to Both Aminopyrazole and Spiroindolone Antimalarials

ACS Chemical Biology, 2014
Aminopyrazoles are a new class of antimalarial compounds identified in a cellular antiparasitic screen with potent activity against Plasmodium falciparum asexual and sexual stage parasites.
E. Flannery, C. McNamara, Sang Wan Kim, Tomoyo Sakata Kato, Fengwu Li, Christine H. Teng, Kerstin Gagaring, M. Manary, Rachel Barboa, S. Meister, K. Kuhen, J. Vinetz, A. Chatterjee, E. Winzeler   +13 more
semanticscholar   +1 more source

Oxygenated Solanapyrone Analogs From Nigrospora sp. IQ‐064, a Mangrove Associated Fungus

Chemistry &Biodiversity, EarlyView.
ABSTRACT Two new oxygenated solanapyrone analogues, nigrosporapyrone E (1) and nigrosporapyrone F (2), were isolated from Nigrospora sp. strain IQ‐064, a fungus associated with the bark of black mangrove (Avicennia germinans L.), along with seven known compounds.
Carlos A. Fajardo‐Hernández, Ángel Sahid Aguilar‐Colorado, Leslie Maribel Corona‐Cabello, Ingrid Y. Martínez‐Aldino, José Rivera‐Chávez   +4 more
wiley   +1 more source

Chloroquine and hydroxychloroquine are associated with reduced cardiovascular risk: a systematic review and meta-analysis

Drug Design, Development and Therapy, 2018
Dan Liu,1,* Xiaodan Li,2,* Yonggang Zhang,3 Joey Sum-Wing Kwong,4,5 Ling Li,6 Yiyi Zhang,1 Chang Xu,6 Qianrui Li,1 Xin Sun,6 Haoming Tian,1 Sheyu Li1,7 1Department of Endocrinology and Metabolism, West China Hospital, Sichuan University, Chengdu 610041,
Liu D, Li X, Zhang Y, Kwong JSW, Li L, Zhang Y, Xu C, Li Q, Sun X, Tian H, Li S   +10 more
doaj  

Antimaláricos e Ototoxicidade Antimalarials and Ototoxicity

Revista Brasileira de Reumatologia, 2004
Os antimaláricos, como o difosfato de cloroquina, têm sido usados amplamente no tratamento não só da malária, mas também de doenças reumatológicas como a síndrome de Sjögren (SS), artrite reumatóide (AR) e lúpus eritematoso sistêmico (LES).
Marcelo Cardoso Figueiredo, Ciríaco Cristóvão C. T. Atherino, Clarice Viana Monteiro, Roger Abramino Levy   +3 more
doaj   +1 more source

Clinically Relevant Interactions between Atypical Antipsychotics and Anti-Infective Agents

Pharmaceuticals, 2020
This is a comprehensive review of the literature on drug interactions (DIs) between atypical antipsychotics and anti-infective agents that focuses on those DIs with the potential to be clinically relevant and classifies them as pharmacokinetic (PK) or ...
Edoardo Spina, Maria Antonietta Barbieri, Giuseppe Cicala, Jose de Leon   +3 more
doaj   +1 more source

Insecticide-treated bednets for the prevention of Plasmodium falciparum malaria in Cambodia: a cluster-randomized trial.

, 2006
OBJECTIVES: To validate and quantify the impact of insecticide-treated bednets (ITN) on malaria morbidity and mortality in Cambodia. METHODS: A paired, cluster-randomized trial of ITN was conducted in Rattanakiri, North East Cambodia.
Alexander, N, Hewitt, S, Nguon, C, Okell, L, Rowland, M, Sochantha, T, Socheat, D, Vannara, H, Yeung, S   +8 more
core   +1 more source

Modular Synthesis of Unsymmetrical 1,1’‐Disubstituted Ferrocenes by Sequential Suzuki‐Miyaura Cross‐Coupling of 1,1’‐Diborylferrocene

Chemistry – A European Journal, EarlyView.
A facile synthesis of unsymmetrical 1,1’‐disubstituted ferrocene derivatives based on the desymmetrization of 1,1’‐diborylferrocene was developed. Suzuki‐Miyaura cross‐coupling (SMCC) reaction of 1,1’‐diborylferrocene afforded mono‐substituted products without significant loss of the second boryl group, and the subsequent second SMCC reaction afforded ...
Kotaro Ochiai, Ryo Yonezawa, Shinya Fujii   +2 more
wiley   +1 more source

Factors Associated with Severe Disease from Malaria, Pneumonia and Diarrhea among Children in Rural Tanzania - a Hospital-Based Cross-Sectional Study. [PDF]

, 2012
Mild cases of malaria, pneumonia and diarrhea are readily treatable with complete recovery and with inexpensive and widely available first-line drugs. However, treatment is complicated and expensive, and mortality is higher when children present to the ...
Hinderaker, Sven Gudmund, Kahabuka, Catherine, Kvåle, Gunnar   +2 more
core   +2 more sources

Developing regional weight-for-age growth references for malaria-endemic countries to optimize age-based dosing of antimalarials

Bulletin of the World Health Organization, 2014
Objective To derive regional weight-for-age growth references to help optimize age-based dosing of antimalarials in Africa, the Americas, South-East Asia and the Western Pacific.
Daniel J Hayes, S. van Buuren, F. T. ter Kuile, D. Stasinopoulos, R. Rigby, D. Terlouw   +5 more
semanticscholar   +1 more source

Molecular Docking and Target‐Specific Binding Profiles of Benzosuberane‐Based Compounds

ChemMedChem, EarlyView.
Benzosuberane represents a promising scaffold in medicinal chemistry. Several benzosuberane‐based derivatives are described in this review as anticancer agents, including antivascular agents, DNA‐intercalators, receptor modulators and kinase inhibitors.
Michail A. Saragatsis, Gemma K. Kinsella, James F. Curtin, Tao Zhang   +3 more
wiley   +1 more source