Results 121 to 130 of about 54,267 (309)

Successful Use of Bimekizumab in Refractory Acute Generalised Exanthematous Pustulosis Triggered by Amoxicillin‐Clavulanate

JEADV Clinical Practice, EarlyView.
ABSTRACT Acute generalised exanthematous pustulosis (AGEP) is a rare, acute neutrophilic dermatosis most commonly triggered by drugs, which typically resolves within 2 weeks following withdrawal of the causative agent. Topical and systemic corticosteroids remain the standard treatment.
Alexandra Junge, Charlotte Vogel, Theresa Hempel, Basil Signer, Nikhil Yawalkar, Kristine Heidemeyer   +5 more
wiley   +1 more source

NK cells as effectors of acquired immune responses: effector CD4+ T cell-dependent activation of NK cells following vaccination.

, 2010
We characterized vaccine-induced cellular responses to rabies virus in naive adult volunteers. Contrary to current paradigms, we observed potent and prolonged in vitro NK cell cytokine production and degranulation responses after restimulation of PBMCs ...
Behrens, Ron H, Fooks, Anthony R, Horowitz, Amir, Okell, Lucy, Riley, Eleanor M   +4 more
core   +1 more source

Comprehensive Insights into Natural Bioactive Compounds: From Chemical Diversity and Mechanisms to Biotechnological Innovations and Applications

ChemistryOpen, EarlyView.
Natural products derived from plants, animals, fungi, bacteria, and minerals contain diverse bioactive classes such as alkaloids, flavonoids, terpenoids, saponins, tannins, and phenolics. These natural products work through different mechanisms, including ROS inhibition, NF‐κB suppression, and cytokine regulation, and exhibit wide applications across ...
Sajid Ali, Atif Ali Khan Khalil, Muhammad Saeed Akhtar, Adnan Amin, Wajid Zaman   +4 more
wiley   +1 more source

Antimaláricos e Ototoxicidade Antimalarials and Ototoxicity

Revista Brasileira de Reumatologia, 2004
Os antimaláricos, como o difosfato de cloroquina, têm sido usados amplamente no tratamento não só da malária, mas também de doenças reumatológicas como a síndrome de Sjögren (SS), artrite reumatóide (AR) e lúpus eritematoso sistêmico (LES).
Marcelo Cardoso Figueiredo, Ciríaco Cristóvão C. T. Atherino, Clarice Viana Monteiro, Roger Abramino Levy   +3 more
doaj   +1 more source

Efficient One‐Pot Synthesis of Benzothiazole Compounds From Vinamidinium Salts

ChemistryOpen, EarlyView.
A catalyst‐free one‐pot reaction of vinamidinium salts with benzothiazole hydrazines efficiently produces 1,3‐bis((3‐methylbenzo[d]thiazol‐2(3H)‐ylidene)hydrazineylidene)propan‐2‐ol (BBTA) and 1‐((1Z,3E)‐1‐(dimethylamino)‐3‐(((Z)‐3‐methylbenzo[d]thiazol‐2(3H)‐ylidene)hydrazineylidene)prop‐1‐en‐2‐yl)pyridin‐1‐ium (DMBT) derivatives.This simple method ...
Zeinab khosravi, Abdolmohammad Mehranpour, Mohammad Reza Mohammadizadeh, Genta Kojya, Satoru Arimitsuc   +4 more
wiley   +1 more source

Antimalarial drug resistance [PDF]

Journal of Clinical Investigation, 2004
Malaria, the most prevalent and most pernicious parasitic disease of humans, is estimated to kill between one and two million people, mainly children, each year. Resistance has emerged to all classes of antimalarial drugs except the artemisinins and is responsible for a recent increase in malaria-related mortality, particularly in Africa.
openaire   +4 more sources

Advancing pharmacometrics in Africa—Transition from capacity development toward job creation

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 407-419, March 2025.
Abstract Trained pharmacometricians remain scarce in Africa due to limited training opportunities, lack of a pharmaceutical product development ecosystem, and emigration to high‐income countries. The Applied Pharmacometrics Training (APT) fellowship program was established to address these gaps and specifically foster job creation for talent retention.
Goonaseelan (Colin) Pillai, Samer Mouksassi, Innocent G. Asiimwe, Craig R. Rayner, Steven Kern, Phumla Sinxadi, Paolo Denti, Eric Decloedt, Catriona Waitt, Bernhards R. Ogutu, Rik de Greef   +10 more
wiley   +1 more source

Harnessing Natural Compounds in Psoriasis: Targeting Cellular Pathways for Effective Therapy

Phytotherapy Research, EarlyView.
Natural compounds act on key cellular pathways in psoriasis by suppressing keratinocyte hyperproliferation, modulating Th17/IL‐17‐mediated immune responses, and reducing oxidative stress. These multi‐target effects highlight their potential as safer adjunctive therapies alongside conventional treatments.
Hye Jin Lee, Yu Jin So, Il‐Joo Jo, Ji Yong Jang, Tae Han Yook, Jun Ho Lee, Sung Wook Kim, Kangwook Lee, Soo Jung Park, Gabsik Yang   +9 more
wiley   +1 more source

A comprehensive revision on the use of quinoline antimalarial drugs as leishmanicidal agents

Frontiers in Chemistry
Antimalarial drugs based on quinolines have been widely used as leishmanicidal agents for either cutaneous or visceral leishmaniasis models. Herein, we showed the leishmanicidal response against in vitro models of different Leishmania spp. and against in
Romina E. Avanzo, Guadalupe García Liñares, Noris Rodríguez, Angel H. Romero   +3 more
doaj   +1 more source

Rapid Structural Analysis of Natural Products Using MicroED

Small, EarlyView.
The cryoEM method, MicroED used for rapid analysis and structure determination of natural products that remained unattainable by other structural biology methods ABSTRACT Structural analysis of natural products remains challenging due to their inherent complexity and limited availability.
Jieye Lin, Orel Paz, Johan Unge, Tamir Gonen   +3 more
wiley   +1 more source