Results 121 to 130 of about 51,125 (324)
Intramolecular Hydrogen Bonds in Conformers of Quinine and Quinidine: An HF, MP2 and DFT Study
Molecules, 2017 Quinine is an alkaloid with powerful antimalarial activity, isolated from the bark of Peru’s cinchona trees. Quinidine is an erythro diastereoisomer of quinine also exhibiting antimalarial activity.
Mireille K. Bilonda, Liliana Mammino
doaj +1 more source
The multifocal pattern electroretinogram in chloroquine retinopathy [PDF]
, 2004 Purpose: Optimal screening for ocular toxicity caused by chloroquine and hydroxychloroquine is still controversial. With the multifocal pattern electroretinogram (mfPERG), a new electrophysiological technique has recently become available to detect early
Arden, G. B. +4 more
core +1 more source
Amazonian Plant Natural Products: Perspectives for Discovery of New Antimalarial Drug Leads
Molecules, 2013 Plasmodium falciparum and P. vivax malaria parasites are now resistant, or showing signs of resistance, to most drugs used in therapy. Novel chemical entities that exhibit new mechanisms of antiplasmodial action are needed.
Lucio H. Freitas-Junior +10 more
doaj +1 more source
iLABMED, EarlyView.The detection rate of enzymatic recombinase amplification (ERA) was better than that of the rapid diagnostic test. The ERA assay was more convenient than fluorescence quantitative PCR. The ERA assay can be used as a complementary tool for malaria screening and clinical diagnosis.
Xinxin Yang +5 more
wiley +1 more source
Artemether resistance in vitro is linked to mutations in PfATP6 that also interact with mutations in PfMDR1 in travellers returning with Plasmodium falciparum infections. [PDF]
, 2012 BACKGROUND: Monitoring resistance phenotypes for Plasmodium falciparum, using in vitro growth assays, and relating findings to parasite genotype has proved particularly challenging for the study of resistance to artemisinins.
Khairnar, K +6 more
core +1 more source
Infection and Drug Resistance, 2022 Tekassa T, Hasen G, Merga H, Cavin AL, Graz B, Suleman S. Infect Drug Resist. 2022;15:3087-3095. Page 3087, Introduction, line 2, the text “4,50,000” should read “450,000”.
Tekassa T +5 more
doaj
Mass Spectrometry Reviews, EarlyView.Abstract Cyclodepsipeptides (CDPs) represent a huge family of chemically and structurally diverse molecules with a wide ability for molecular interactions. CDPs are cyclic peptide‐related natural products made up of both proteinogenic and nonproteinogenic amino acids linked by amide and ester bonds.
Sophie Liuu +10 more
wiley +1 more source
, 2007 Piperaquine is being developed as a long-acting component in artemisinin combination therapies. It was highly active in vitro and drug interaction studies showed that dihydroartemisinin combinations with piperaquine, chloroquine, and amodiaquine were ...
Adagu, Ipemida S +2 more
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ChemistryOpen, EarlyView.Quinazoline represents an important class of heterocycles with diverse medicinal and pharmacological significance. This review systematically examines scholarly efforts toward understanding different synthetic pathways emphasizing the role of metal and non‐metal catalysts including some miscellaneous reagents employed in the synthesis of quinazoline ...
Neha Manhas +4 more
wiley +1 more source
Exploring a Water–Ethyl Acetate System for the Efficient Synthesis of 4‐Aryl Quinolines
ChemistryOpen, EarlyView.A sustainable and catalyst‐free method for synthesizing 4‐aryl quinolines is developed using a water–ethyl acetate solvent system under reflux conditions. This approach eliminates hazardous reagents while achieving high yields and purity. The protocol aligns with green chemistry principles, offering an efficient and environmentally friendly alternative
Mohammad Qandalee +4 more
wiley +1 more source