Results 131 to 140 of about 91,276 (376)

NK cells as effectors of acquired immune responses: effector CD4+ T cell-dependent activation of NK cells following vaccination.

, 2010
We characterized vaccine-induced cellular responses to rabies virus in naive adult volunteers. Contrary to current paradigms, we observed potent and prolonged in vitro NK cell cytokine production and degranulation responses after restimulation of PBMCs ...
Behrens, Ron H, Fooks, Anthony R, Horowitz, Amir, Okell, Lucy, Riley, Eleanor M   +4 more
core   +1 more source

Oxidative phosphorylation at the crossroads of cancer: Metabolic orchestration, stromal collusion, and emerging therapeutic horizons

Interdisciplinary Medicine, EarlyView.
Although most cancer cells rely on aerobic glycolysis, Oxidative phosphorylation (OXPHOS) remains essential for their survival, proliferation, and metastasis. With the emergence of OXPHOS‐targeted drugs, its therapeutic potential is becoming increasingly evident.
Keke Chen, Bo Wang, Hongying Shu, Jianxin Lyu, Wei Cui, Hezhi Fang   +5 more
wiley   +1 more source

Use of antimalarials in dermatology [PDF]

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, 2010
SummaryThe antimalarials chloroquine and hydroxychloroquine have been used for the treatment of inflammatory diseases for more than 60 years. Even today new indications evolve due to the complex mode of action of these compounds. Due to the fear of side effects, especially irreversible retinopathy, their use is often limited.
openaire   +3 more sources

Bio‐Mediated Synthesis of CuO Nanoparticle for Antibacterial and Antioxidant Applications via Croton macrostachyus Hochst. Ex Delile Leaf Extract

Natural Sciences, EarlyView.
ABSTRACT The advancement of green technology is a key focus of global research aimed at synthesis of environmentally friendly, cost‐effective, and biocompatible copper oxide nanoparticles. This study involved the synthesis of CuO nanoparticles (CuO NPs) using hydrated copper sulfate as a precursor and Croton macrostachyus Hochst. ex Delile leaf extract
Adem Hussen, Sisay Awoke Endalew, Belete Tesfaw Abebaw, Assamen Ayalew Ejigu, Anteneh Yayeh Adamu, Demissie Mulu Eneyew, Asmare Belay Nigussie   +6 more
wiley   +1 more source

STUDIES ON THE CHEMOTHERAPY OF THE HUMAN MALARIAS. I. METHOD FOR THE QUANTITATIVE ASSAY OF SUPPRESSIVE ANTIMALARIAL ACTION IN VIVAX MALARIA 123 [PDF]

, 1948
James A. Shannon, David P. Earle, Robert W. Berliner, John V. Taggart   +3 more
openalex   +1 more source

Efficient Synthesis of 1‐Chloroimidazo[1,2‐a:4,5‐c']dipyridines, Versatile Synthons for Position‐1 Functionalisation with Various Reagents

ChemistryOpen, EarlyView.
Imidazo[1,2‐a:4,5‐c']dipyridines are remarkable skeletons in the field of medicinal chemistry. This article presents the synthesis of 1‐chloroimidazo[1,2‐a:4,5‐c']dipyridines, versatile synthons to functionalize at position‐1. Several examples of further reactions are presented, including Suzuki–Miyaura and Sonogashira cross‐couplings, nucleophilic ...
Romain Dussart, Mélanie Pénichon, Pierre‐Olivier Delaye, Cécile Enguehard‐Gueiffier   +3 more
wiley   +1 more source

THE GLUCOSE METABOLISM OF PLASMODIUM GALLINACEUM, AND THE ACTION OF ANTIMALARIAL AGENTS [PDF]

, 1948
P. B. MARSHALL
openalex   +1 more source

One‐Pot Synthesis of Novel β‐Carboline‐{α‐Acylaminoamide}‐Bisindole Derivatives: Antibacterial Evaluation, Molecular Docking, and Density Functional Theory Studies

ChemistryOpen, EarlyView.
A new series of β‐carboline‐{α‐acylaminoamide}‐bisindole hybrids (12a–l) employing an atom‐economical one‐pot Ugi four‐component reaction and their antibacterial testing alongside docking studies, is reported. A new series of β‐carboline‐{α‐acylaminoamide}‐bisindole hybrids (12a–l) is designed and synthesized employing an atom‐economical one‐pot Ugi ...
Ankit Kumar Atri, Lavanya Khullar, Gobind Kumar, Sahil Mishra, Tamanna Dua, Vinay Singh, Kusum Harjai, Parvesh Singh, Vasundhara Singh   +8 more
wiley   +1 more source

Knowledge and practices relating to malaria in a semi-urban area of Cameroon: choices and sources of antimalarials, self-treatment and resistance

The Pan African Medical Journal, 2011
BACKGROUND: Malaria is a major public health problem in Sub-Saharan Africa where it kills a child under the age of five every 30 seconds. In Cameroon, malaria accounts for 40-45% of medical consultations, 57% of hospitalization days and 40% of mortality ...
Dickson Shey Nsagha, Anna Longdoh Njunda, Henri Lucien Foumou Kamga, Sarah Mboshi Nsagha, Jules Clement Nguedia Assob, Charles Shey Wiysonge, Earnest Njih Tabah, Alfred Kongnyu Njamnshi   +7 more
doaj   +1 more source

STUDIES ON THE CHEMOTHERAPY OF THE HUMAN MALARIAS. VI. THE PHYSIOLOGICAL DISPOSITION, ANTIMALARIAL ACTIVITY, AND TOXICITY OF SEVERAL DERIVATIVES OF 4-AMINOQUINOLINE 12 [PDF]

, 1948
Robert W. Berliner, David P. Earle, John V. Taggart, C. Gordon Zubrod, William J. Welch, Neal J. Conan, Eli Bauman, Sidney Scudder, James A. Shannon   +8 more
openalex   +1 more source