Results 31 to 40 of about 51,125 (324)

Comparison of Health Service Utilization for Febrile Children Before and After Introduction of Malaria Rapid Diagnostic Tests and Artemisinin-Based Combination Therapy in Rural Papua New Guinea

Frontiers in Public Health, 2018
BackgroundIn Papua New Guinea (PNG), a malaria treatment policy using rapid diagnostic tests (RDTs) plus artemisinin-based combination therapy (ACT) was widely introduced to rural communities in 2012.
Takahiro Tsukahara, Takahiro Tsukahara, Takuma Sugahara, Takuro Furusawa, Francis Wanak Hombhanje   +4 more
doaj   +1 more source

Targeting proteases and proteolytic processing of unusual N-terminal extensions of Plasmodium proteins: parasite peculiarity

Frontiers in Drug Discovery, 2023
More than sesquicentennial years of malarial research, however the unique malarial parasite, Plasmodium still bewilders us with its atypical characteristic features.
Ankita Tehlan, Abhik Saha, Abhik Saha, Suman Kumar Dhar   +3 more
doaj   +1 more source

Susceptibilidad in vitro de aislamientos colombianos de Plasmodium falciparum a diferentes antipalúdicos

Biomédica: revista del Instituto Nacional de Salud, 2008
Introducción. Los estudios de susceptibilidad in vitro de Plasmodium falciparum a los medicamentos antipalúdicos son herramientas importantes para vigilar la utilidad de esos medicamentos; tales estudios son escasos en Colombia. Objetivo.
Silvia Blair, Eliana Arango, Jaime Carmona Fonseca   +2 more
doaj   +1 more source

Retinal toxicity induced by antimalarial drugs: literature review and case report

Medwave, 2016
Los antipalúdicos son fármacos ampliamente utilizados en varios países para el control de enfermedades reumatológicas como el lupus eritematoso sistémico y la artritis reumatoide. En México continúan siendo muy aceptados por su bajo costo y pocos efectos
Manuel Garza-Leon, Diana Elsa Flores-Alvarado, Juan Manuel Muñoz-Bravo   +2 more
doaj   +1 more source

Comparative analysis of two methods for measuring sales volumes during malaria medicine outlet surveys. [PDF]

, 2013
BACKGROUND: There is increased interest in using commercial providers for improving access to quality malaria treatment. Understanding their current role is an essential first step, notably in terms of the volume of diagnostics and anti-malarials they ...
Goodman, Catherine, Hanson, Kara, Kleinschmidt, Immo, O'Connell, Kate, Palafox, Benjamin, Patouillard, Edith, Pok, Sochea, Tougher, Sarah   +7 more
core   +2 more sources

The ATM Kinase Inhibitor AZD0156 Is a Potent Inhibitor of Plasmodium Phosphatidylinositol 4‐Kinase (PI4Kβ) and Is an Attractive Candidate for Medicinal Chemistry Optimization Against Malaria

Angewandte Chemie, EarlyView.
AZD0156, an ATM kinase inhibitor in clinical development, shows promising multistage antiplasmodial activity by targeting Plasmodium falciparum phosphatidylinositol 4‐kinase (PfPI4Kβ). With an improved specificity profile relative to other PfPI4Kβ inhibitors and moderate efficacy in a P.
John G. Woodland, Dina Coertzen, Kathryn J. Wicht, Virginia Franco Hidalgo, Charisse Flerida A. Pasaje, Luiz C. Godoy, Tarrick Qahash, Mmakwena M. Mmonwa, Godwin A. Dziwornu, Lynn Wambua, Sarah Harries, Constance M. Korkor, Mathew Njoroge, Liezl Krugmann, Dale Taylor, Meta Leshabane, Henrico Langeveld, Tayla Rabie, Janette Reader, Mariëtte van der Watt, Nelius Venter, Erica Erlank, Ayesha S. Aswat, Lizette L. Koekemoer, Tomas Yeo, Jin H. Jeon, David A. Fidock, Francisco Javier Gamo, Sergio Wittlin, Jacquin C. Niles, Manuel Llinas, Lauren B. Coulson, Lyn‐Marié Birkholtz, Kelly Chibale   +33 more
wiley   +2 more sources

Malaria: The Past and the Present

Microorganisms, 2019
Malaria is a severe disease caused by parasites of the genus Plasmodium, which is transmitted to humans by a bite of an infected female mosquito of the species Anopheles.
Jasminka Talapko, Ivana Škrlec, Tamara Alebić, Melita Jukić, Aleksandar Včev   +4 more
doaj   +1 more source

Impact of Drug Pressure versus Limited Access to Drug in Malaria Control: The Dilemma

Medicines, 2022
Malaria burden has severe impact on the world. Several arsenals, including the use of antimalarials, are in place to curb the malaria burden. However, the application of these antimalarials has two extremes, limited access to drug and drug pressure ...
Chinedu Ogbonnia Egwu, Nwogo Ajuka Obasi, Chinyere Aloke, Joseph Nwafor, Ioannis Tsamesidis, Jennifer Chukwu, Sunday Elom   +6 more
doaj   +1 more source

Optimal design of experiments by combining coarse and fine measurements [PDF]

Phys. Rev. Lett. 119, 208101 (2017), 2017
In many contexts it is extremely costly to perform enough high quality experimental measurements to accurately parameterize a predictive quantitative model. However, it is often much easier to carry out large numbers of experiments that indicate whether each sample is above or below a given threshold.
arxiv   +1 more source

Development of an Organoautocatalyzed Double σ‐Bond C(sp2)‐N Transamination Metathesis Reaction

Angewandte Chemie, EarlyView.
Organoautocatalyzed transamination metathesis of cyclic tertiary amines is disclosed as a high‐yielding, scalable reaction that proceeds under mild, catalyst‐free conditions. It operates via a multi‐step domino reaction mechanism, where an in situ‐formed pyrrolidinium salt functions as a HBD organoautocatalyst.
Volker Klein, Florian Schuster, Jonas Amthor, Harald Maid, Prabhakar Bijalwan, Fahmi Himo, Stefano Santoro, Svetlana B. Tsogoeva   +7 more
wiley   +2 more sources