Results 71 to 80 of about 91,276 (376)
The challenge of chloroquine-resistant malaria in sub-Saharan Africa.
, 2001 For the last decade chloroquine-resistant Plasmodium falciparum (CRPF) has spread explosively in sub-Saharan Africa. In some areas of the continent, CRPF is so intense that chloroquine can hardly be said to have any efficacy.
Nuwaha, F
core +1 more source
In vivo assessment of drug efficacy against Plasmodium falciparum malaria: duration of follow-up. [PDF]
, 2004 To determine the optimum duration of follow-up for the assessment of drug efficacy against Plasmodium falciparum malaria, 96 trial arms from randomized controlled trials (RCTs) with follow-up of 28 days or longer that were conducted between 1990 and 2003
Adjuik, M +16 more
core +3 more sources
Drug Design, Development and Therapy, 2016 Malaria disease continues to be a major health problem worldwide due to the emergence of multidrug-resistant strains of Plasmodium falciparum. In recent days, artemisinin (ART)-based drugs and combination therapies remain the drugs of choice for ...
M. Rudrapal, D. Chetia
semanticscholar +1 more source
Knowledge among Drug Dispensers and Antimalarial Drug Prescribing Practices in Public Health Facilities in Dar es Salaam. [PDF]
, 2013 Irrational prescribing and dispensing of antimalarials has been identified as a contributing factor in the emergence of malaria parasites resistant to existing antimalarial drugs.
Kamuhabwa, Appolinary Ar +1 more
core +2 more sources
Antimalarial Activity of Piperine
Journal of Tropical Medicine, 2018 Malaria remains a public health problem in tropical and subtropical regions. Resistance of Plasmodium falciparum to artemisinins in Southeast Asia is a great concern for disease control and research on discovery and development of new alternative antimalarial drugs is urgently required. In a previous study, the fruit of Piper chaba Hunt.
Artitaya Thiengsusuk +3 more
openaire +3 more sources
A Novel Antimalarial Agent that Inhibits Protein Synthesis in Plasmodium falciparum
Angewandte Chemie International Edition, EarlyView.Compound 31 represents a promising avenue for the development as an antimalarial agent with a potent activity profile (PfNF54 IC50 ± s.d. = 3.9 ± 0.4 nM). It has a novel mode of action by binding to cytosolic ribosomal subunits, thereby inhibiting protein synthesis in the parasite.
Patricia Bravo +16 more
wiley +1 more source
Frontiers in Pharmacology, 2023 Due to the outbreak of the SARS-CoV-2 virus, drug repurposing and Emergency Use Authorization have been proposed to treat the coronavirus disease 2019 (COVID-19) during the pandemic. While the efficiency of the drugs has been discussed, it was identified
Seung-Hyun Yoon +6 more
doaj +1 more source
Microbiology Spectrum, 2021 The emergence of resistance to antimalarials has prompted the steady switch to novel therapies for decades. Withdrawal of antimalarials, such as chloroquine in sub-Saharan Africa in the late 1990s, led to rapid declines in the prevalence of resistance ...
Antoine Berry +9 more
doaj +1 more source
Solution‐Based Biophysical Methods for Guiding Design of Aptamers into Electrochemical Biosensors
Analysis &Sensing, EarlyView.It is found that aptamer binding and folding thermodynamics measured via isothermal titration calorimetry and nano differential scanning calorimetry directly correlate with electrochemical aptamer‐based biosensor response. We show that these techniques report on the magnitude of conformational change and could be used as guides to help engineer ...
Minh‐Dat Nguyen +4 more
wiley +1 more source
Memorias do Instituto Oswaldo Cruz, 2015 Several species of Aspidospermaplants are used to treat diseases in the tropics, including Aspidosperma ramiflorum, which acts against leishmaniasis, an activity that is experimentally confirmed.
Anna CC Aguiar +5 more
doaj +1 more source