Results 101 to 110 of about 32,473 (237)

Compound Library Screening Identified Cladribine as a Novel Radiosensitizer for Prostate Cancer

Cancer Science, Volume 117, Issue 4, Page 1136-1147, April 2026.
The combination of cladribine and irradiation significantly suppressed the growth of DU145‐derived tumors compared with the DMSO plus irradiation group in the mouse model. In addition, it also elevated the percentage of γH2AX‐positive cells after irradiation.
Toshiki Oka, Koji Hatano, Shohei Katsuki, Tomohiro Kanaki, Shunsuke Inoguchi, Masaru Tani, Akihiro Yoshimura, Yuki Horibe, Yutong Liu, Nesrine Sassi, Yohei Okuda, Akinaru Yamamoto, Toshihiro Uemura, Gaku Yamamichi, Yu Ishizuya, Takuji Hayashi, Yoshiyuki Yamamoto, Taigo Kato, Atsunari Kawashima, Keisuke Tamari, Bangzhong Lin, Akiyoshi Tani, Kazutake Tsujikawa, Yutaka Takahashi, Kazuhiko Ogawa, Shawn E. Lupold, Norio Nonomura   +26 more
wiley   +1 more source

Variabilidad fitoquímica y repercusión antinutricional potencial en especies del género Albizia Phytochemical variability and potential antinutritional repercussion in species of the Albizia genus

Pastos y Forrajes, 2007
Mediante los análisis de componentes principales (ACP), clasificación automática (ACA) y varianza simple (ANOVA), se estudió el espectro de variaciones de la composición química de once especies del género Albizia (A. berteriana, A. caribaea, A.
D.E García, María Gabriela Medina, F Ojeda, J Humbría, C Domínguez, A Baldizán, Odalys Toral   +6 more
doaj  

Feasibility of Early Oral Nutritional Supplementation After Liver Transplantation: A Randomized Pilot Study

Clinical Transplantation, Volume 40, Issue 4, April 2026.
ABSTRACT Catabolic and inflammatory changes after liver transplantation (LT) increase energy and protein requirements. This study assessed the feasibility of a 12‐week high‐energy/high‐protein oral nutrition supplementation (ONS) initiated after resumption of solid oral intake post‐LT.
Amal Trigui, Crystèle Hogue, Mélanie Tremblay, Geneviève Huard, An Tang, Justine Racette, Christopher F. Rose, Chantal Bémeur   +7 more
wiley   +1 more source

New antimetabolites in cancer chemotherapy and their clinical impact.

British Journal of Cancer, 1998
It is almost 50 years since antimetabolites were first found to have clinical antitumour activity, with Farber's discovery that aminopterin could cause remission in acute leukaemia.
S. Kaye
semanticscholar   +1 more source

Graft and Patient Survival After Liver Transplantation for Primary Sclerosing Cholangitis: A French National Cohort Study

Liver International, Volume 46, Issue 4, April 2026.
ABSTRACT Background A significant proportion of patients presenting a primary sclerosing cholangitis (PSC) will require liver transplantation (LT). The present study aimed to investigate graft loss and patient death in a large cohort of patients. Methods We conducted a nationwide multicenter retrospective study including all adult patients transplanted
Florian Veyre, Claire Francoz, Domitille Erard, Eleonora DeMartin, Laure Elkrief, Camille Besch, Olivier Boillot, Filomena Conti, Sébastien Dharancy, Christophe Duvoux, Jean Gugenheim, Jean Hardwigsen, Marie‐Noëlle Hilleret, Vincent Leroy, Isabelle Ollivier‐Hourmand, Marilyne Gratien, Pauline Houssel‐Debry, Nassim Kamar, Olivier Roux, Jean‐Baptiste Hiriart, Marie Irles‐Depe, Sophie Pellegrin, François Durand, Georges‐Philippe Pageaux, Stéphanie Faure, Audrey Coilly, Sylvie Radenne, Faouzi Saliba, Didier Samuel, Claire Vanlemmens, Marianne Latournerie, Karim Boudjema, Ephrem Salamé, Olivier Chazouillères, Christophe Corpechot, Jérôme Dumortier   +35 more
wiley   +1 more source

A programme for risk assessment and minimisation of progressive multifocal leukoencephalopathy developed for vedolizumab clinical trials [PDF]

, 2018
Introduction Over the past decade, the potential for drug-associated progressive multifocal leukoencephalopathy (PML) has become an increasingly important consideration in certain drug development programmes, particularly those of immunomodulatory ...
Berger, Joseph R, Clifford, David B, Fox, Irving, Lev, Michael H, Major, Eugene, McAuliffe, Megan, Milch, Catherine, Parikh, Asit, Patti, Mark, Provenzale, James M, Sankoh, Serap, Shick, Jesse, Stephens, Kristin   +12 more
core   +3 more sources

Exercise prehabilitation for brain health and sensory–cognitive function: Mechanistic insights into brain–body interactions

Experimental Physiology, Volume 111, Issue 4, Page 1695-1699, 1 April 2026.
Abstract This mini review article presents a novel hypothesis for extending exercise prehabilitation into the domains of brain health and cognition. Whilst prehabilitation has been gaining popularity in cancer treatment, conferring significant positive benefits to numerous physiological indicators, including post‐operative infection and hospital length
Helen E. Nuttall, Daren Subar, Christopher J. Gaffney   +2 more
wiley   +1 more source

Leftover mitomycin-c sponge causing blebitis

Indian Journal of Ophthalmology, 2019
Trabeculectomy is the commonest surgical intervention performed worldwide for the treatment of open-angle glaucoma. However, the use of antimetabolites during trabeculectomy has been associated with various bleb related complications.
Mayuri Khamar, Deepak Bhojwani, Priyanka Patel, Abhay Vasavada   +3 more
doaj   +1 more source

Cisplatin resistance coupled to enhanced sensitivity to metabolic interventions

Molecular & Cellular Oncology, 2018
Specific metabolic alterations have recently been observed in cisplatin-resistant cancers. As a result, cisplatin resistance can be overcome by co-administration of pyridoxine, and cisplatin-resistant cancer cells become exquisitely sensitive to killing ...
Maria Castedo, Florine Obrist, Guido Kroemer   +2 more
doaj   +1 more source

Resistance to chemotherapeutic antimetabolites: a function of salvage pathway involvement and cellular response to DNA damage.

British Journal of Cancer, 1997
The inherent or acquired (induced) resistance of certain tumours to cytotoxic drug therapy is a major clinical problem. There are many categories of cytotoxic agent: the antimetabolites, e.g.
A. Kinsella, D. Smith, M. Pickard
semanticscholar   +1 more source