Results 91 to 100 of about 16,625 (206)
Pastos y Forrajes, 2007 Mediante los análisis de componentes principales (ACP), clasificación automática (ACA) y varianza simple (ANOVA), se estudió el espectro de variaciones de la composición química de once especies del género Albizia (A. berteriana, A. caribaea, A.
D.E García +6 more
doaj
Indian Journal of Ophthalmology. Case ReportsPseudophakic macular edema (PME) is typically treated with nonsteroidal anti-inflammatory drugs (NSAIDs) initially, followed by steroids. Treatment with steroids becomes challenging in steroid responders. We report a case of PME treated with intravitreal
Simran +3 more
doaj +1 more source
Veterinary and Comparative Oncology, EarlyView.ABSTRACT Effective chemotherapy for canine histiocytic sarcoma (CHS) has yet to be established. In our previous study, CHS cell lines were subclassified into two groups based on their gene expression profiles: Group A and Group B. This study aimed to identify novel therapeutic agents that are effective against each CHS subgroup, and we performed high ...
Hiroki Sakuma +6 more
wiley +1 more source
De novo or Salvage? Nucleotide Availability as a Driver of Bacterial Adaptation and Virulence
MicrobiologyOpen, Volume 15, Issue 4, August 2026.Bacterial pathogens survive in different host environments by switching between making nucleotides by de novo synthesis and scavenging them from the host. This flexibility supports growth and virulence making nucleotide metabolism an attractive therapeutic target.
Riya Joshi +2 more
wiley +1 more source
Possible effects of antimetabolites on virus replication
, 1965 Because of the varied opinions and findings concerning the effect of cellular antimetabolites on the replication of both RNA and DNA-containing animal viruses, this project was undertaken to observe the effects of antimetabolites on Newcastle disease and
McMillan, Jeanette Margot
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, 2022 20 svenska barn diagnostiseras årligen med barntumören neuroblastom (NB). Läkemedelsresistens och intratumoral heterogenitet försvårar behandlingen och 50-60% av hög-risk NB-patienter drabbas av återfall.
Lundström, Maja
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Pigment Cell &Melanoma Research, Volume 39, Issue 4, July 2026.ADI‐PEG20 enhances melphalan‐induced DNA DSBs in UM cells. We describe potentiation of DNA DSBs in UM cell lines upon treatment with ADI‐PEG20 and melphalan (92.1 cells with STRIDE by intoDNA). ADI‐PEG20 suppresses multiple members of the FA pathway—a known resistance mechanism for melphalan—providing a rationale for exploring this drug combination in ...
Iuliia Pavlyk +10 more
wiley +1 more source
Protein antimetabolites in legume seed defense
, 1999 215-222The search for insect resistant chemicals in legume seeds has prompted scientists to identity many antimetabolites that impart resistance against many stored product pests.
Ignacimuthu, S
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International Journal of Cancer, Volume 158, Issue 12, Page 3152-3160, 15 June 2026.What's new? Long‐term immunosuppression in solid organ transplant recipients (SOTRs) is linked to increased cancer risk. Although this risk potentially increases with greater immunosuppressant exposure, the exact dose‐response pattern remains uncertain.
Sergio A. Acuna +10 more
wiley +1 more source
, 2005 These drugs interfere with the production of nucleic acids by three mechanisms. Some inhibit production of the deoxyribonucleoside triphosphates that are the immediate precursors for deoxyribonucleic acid (DNA) synthesis, thus inhibiting the replication ...
Mark L. Moster, MD; Rod Foroozan, MD
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