Results 81 to 90 of about 17,759 (207)

Control of Gemcitabine Activity With Blue and Red Light

Chemistry – A European Journal, Volume 32, Issue 38, 13 October 2026.
Treating cancer with chemotherapy is generally associated with many side effects, which can be addressed by selectively releasing the desired drugs with visible light. Sixteen new blue light‐activatable cytostatics were introduced, with the gemcitabine derivative exhibiting ideal properties.
Nils F. Kersten, Konstantin L. Stock, Marius Hyprath, Hannah Weisser, Timo Weinrich, Dieter Steinhilber, Alexander Heckel   +6 more
wiley   +1 more source

Infantile Central Nervous System Juvenile Xanthogranuloma With Somatic CSF1R Mutation Responsive to Imatinib Monotherapy

Pediatric Blood &Cancer, Volume 73, Issue 10, October 2026.
ABSTRACT Juvenile xanthogranuloma (JXG) of the central nervous system (CNS) is a rare non‐Langerhans cell histiocytosis. CSF1R mutations have been reported for peripheral JXG, but not in CNS JXG. A 3‐month‐old male presented with fever, lymphadenopathy, and macrocephaly with bulging fontanelles.
Sima Vazquez, Kayla Etienne, Long Di, Valerie Martinez‐Torres, Andrew Rosenberg, Sakir H. Gultekin, Aditi Dhir, Bradley Gampel, Heather J. McCrea   +8 more
wiley   +1 more source

Resolution and Quantitation of Ribonucleosides and Deoxyribonucleosides in Digested Genomic DNA by UHPLC–MS/MS

Biomedical Chromatography, Volume 40, Issue 10, October 2026.
ABSTRACT Deoxyuridine (dUrd) is often misincorporated into genomic DNA in cancer patients receiving antimetabolite chemotherapy. This activates base excision repair and recruits ataxia telangiectasia‐mutated and Rad3‐related (ATR), which coordinates DNA repair with nucleotide metabolism by facilitating ribonucleotide reductase (RNR) activity ...
Joshua J. Deppas, Reyna Jones, Robert A. Parise, Pinakin Pandya, Christopher J. Bakkenist, Jan H. Beumer   +5 more
wiley   +1 more source

Extracellularly Activatable Conjugates of RGD Peptidomimetics and Cryptophycin for αVβ3‐Targeted Cancer Therapy

Chemistry – A European Journal, Volume 32, Issue 37, 1 October 2026.
Integrin αVβ3‐targeting small‐molecule drug conjugates (SMDCs) were synthesized by conjugating a cryptophycin payload through a neutrophil elastase‐cleavable NPV‐PABC linker. RGD peptidomimetic and linker epimers served as controls for targeting and enzymatic cleavage, and the resulting conjugates displayed subnanomolar cytotoxicity in vitro.
Dominic Seißenschmidt, Henriette Hartung, Jonah Kammer, Norbert Sewald   +3 more
wiley   +1 more source

Who Should Receive Antimetabolites After Filtering Surgery?

, 1992
Don't tell me what you think that I should do. What would you do if this were your patient?," and so go the questions about the use of antimetabolites with filtering surgery. In practice, many difficult and unresolved issues remain.
Richard K. Parrish, Parrish, Richard K
core   +1 more source

Chemotherapy‐Induced Skeletal Muscle Dysfunction and Cognitive Impairment: A Muscle‐Brain Mechanistic Framework With Implications for Exercise Oncology

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 5, October 2026.
ABSTRACT Chemotherapy commonly induces skeletal muscle dysfunction and cognitive impairment, complications that reduce treatment tolerance and quality of life. Skeletal muscle mass frequently declines during chemotherapy, with cohort studies reporting losses of 3%–10% across treatment courses, while chemotherapy‐induced cognitive impairment affects up ...
SoYoung Ahn, Jin‐Soo Kim, Daniel A. Galvao, Dennis R. Taaffe, Dong Hyun Yoon, Carolyn McIntyre, Christelle Schofield, Yoon Jung Chang, Jihee Min, Wook Song, Robert U. Newton   +10 more
wiley   +1 more source

Walsh & Hoyt: Antimetabolites

, 2005
These drugs interfere with the production of nucleic acids by three mechanisms. Some inhibit production of the deoxyribonucleoside triphosphates that are the immediate precursors for deoxyribonucleic acid (DNA) synthesis, thus inhibiting the replication ...
Mark L. Moster, MD; Rod Foroozan, MD
core  

Antimetabolites in the nutrition of the silkworm bombyx mori L.-I: niacin and pyridoxine antagonists

, 1958
Growth inhibition with antimetabolite and its reversal with the metabolite has been employed as a criterion for studying the nutritional requirement of the silkworm for niacin and pyridoxine.
Bhat, J. V., Shyamala, M. B.
core   +1 more source

Leftover mitomycin-c sponge causing blebitis

Indian Journal of Ophthalmology, 2019
Trabeculectomy is the commonest surgical intervention performed worldwide for the treatment of open-angle glaucoma. However, the use of antimetabolites during trabeculectomy has been associated with various bleb related complications.
Mayuri Khamar, Deepak Bhojwani, Priyanka Patel, Abhay Vasavada   +3 more
doaj   +1 more source

Triazole‐Linked Pyrimidine Nucleoside Dimers: Design, Synthesis, and Applications in Medicinal and Nucleic Acid Chemistry. Part IV

Chemical Biology &Drug Design, Volume 108, Issue 4, October 2026.
A series of 18 pyrimidine nucleoside dimers analogues with a short 1,4‐disubstituted 1,2,3‐triazole linkage were synthesized using a click chemistry approach (CuAAC). Analysis of the obtained products was conducted utilizing 1D/2D NMR spectroscopy (1H, 13C, 19F, 15N, and 29Si), mass spectrometry (ESI‐MS), and high‐performance liquid chromatography ...
Dagmara Baraniak, Dariusz Wawrzyniak, Daniel Baranowski   +2 more
wiley   +1 more source