Results 71 to 80 of about 17,759 (207)

Uptake of purines in Plasmodium falciparum-infected human erythrocytes is mostly mediated by the human Equilibrative Nucleoside Transporter and the human Facilitative Nucleobase Transporter [PDF]

, 2010
<b>Background</b>: Plasmodium parasites are unable to synthesize purines de novo and have to salvage them from the host. Due to this limitation in the parasite, purine transporters have been an area of focus in the search for anti-malarial ...
Neils B Quashie, Lisa C Ranford-Cartwright, Ranford-Cartwright Lisa C, Harry P De Koning, De Koning, H.P., de Koning Harry P, Quashie Neils B, Quashie, N.B., Ranford-Cartwright, L.C.   +8 more
core   +1 more source

The clinical trial landscape of osteosarcoma: integrating trial data, immunotherapeutic trends, and biomarker insights

Frontiers in Immunology
Osteosarcoma, the most aggressive primary malignant bone tumor, has stagnant therapeutic outcomes despite decades of standard MAP chemotherapy and surgery; 5-year overall survival (OS) is <30% for metastatic/recurrent cases.
Lifeng Ge, Tianhao Xu, Xiaodong Gu, Xuekang Pan, Tian Gao, Huigen Lu   +5 more
doaj   +1 more source

Role of antimetabolites in recalcitrant idiopathic orbital inflammatory syndrome

Oman Journal of Ophthalmology, 2011
Background : High-dose systemic steroids are the primary modality of treatment for idiopathic orbital inflammatory syndrome (IOIS). Occasionally patients experience a relapse of symptoms on tapering steroids or require large doses of steroid ...
Yamini Priya, Suneetha Nithyanandam, Manjoo S Reddy   +2 more
doaj   +1 more source

Serial growth plate monitoring in a 3‐month‐old Labrador retriever receiving vinblastine chemotherapy

Veterinary Record Case Reports, Volume 14, Issue 4, November 2026.
Abstract A 3‐month‐old, male, entire Labrador retriever was presented for evaluation of a congenital mast cell tumour of the right pinna. Pinnectomy and regional lymphadenectomy confirmed a high‐grade mast cell tumour with nodal pre‐metastasis. Eight vinblastine chemotherapy treatments were administered over 12 weeks.
Paige A. A. Brown, Kate M. Sippel, Alison Masyr   +2 more
wiley   +1 more source

Photochemical Internalization Using Natural Anticancer Drugs, Antimetabolites, and Nanoformulations: A Systematic Study against Breast and Pancreatic Cancer Cell Lines

, 2023
Photochemical internalization (PCI) is a novel, minimally invasive drug delivery technology that facilitates the delivery of therapeutic molecules into the cytosol of cells.
Alexandra Iliopoulou (14651440), George Pasparakis (2423818), Christopher Barnett (3498812), Fanny Joubert (1463020), Raúl Sánchez Álvarez (14651443)   +4 more
core   +1 more source

Removal of antinutritional factors from bean (Phaseolus vulgaris L.) seeds [PDF]

Biotechnologie, Agronomie, Société et Environnement, 1999
Phytohemagglutinin and the lectin-related proteins present in bean seeds are toxic to monogastric animals and lower the nutritional value of beans. Since these antimetabolites are present in substantial amounts, a breeding program aimed to the removal ...
Bollini R., Carnovale E., Campion B.
doaj  

The efficacy and safety of reducing intraocular pressure to single‐digit levels in Normal‐tension glaucoma: A systematic review and meta‐analysis

Acta Ophthalmologica, Volume 104, Issue 7, Page 720-730, November 2026.
Abstract Purpose This systematic review and meta‐analysis aim to evaluate the efficacy and safety of further lowering intraocular pressure (IOP) to single‐digit levels in treated patients with progressive normal‐tension glaucoma (NTG). Methods A literature search was conducted in MEDLINE (via PubMed), Scopus and Web of Science. We selected studies that
Beatriz Araújo‐Azevedo, Renato Ferreira‐da‐Silva, João Barbosa‐Breda   +2 more
wiley   +1 more source

Combination of Antimetabolites with Chemotherapy as a Novel Treatment Option in High-risk Neuroblastoma

, 2022
20 svenska barn diagnostiseras årligen med barntumören neuroblastom (NB). Läkemedelsresistens och intratumoral heterogenitet försvårar behandlingen och 50-60% av hög-risk NB-patienter drabbas av återfall.
Lundström, Maja
core   +2 more sources

Variabilidad fitoquímica y repercusión antinutricional potencial en especies del género Albizia Phytochemical variability and potential antinutritional repercussion in species of the Albizia genus

Pastos y Forrajes, 2007
Mediante los análisis de componentes principales (ACP), clasificación automática (ACA) y varianza simple (ANOVA), se estudió el espectro de variaciones de la composición química de once especies del género Albizia (A. berteriana, A. caribaea, A.
D.E García, María Gabriela Medina, F Ojeda, J Humbría, C Domínguez, A Baldizán, Odalys Toral   +6 more
doaj  

Pseudophakic macular edema in a steroid responder treated successfully with intravitreal methotrexate: A case report

Indian Journal of Ophthalmology. Case Reports
Pseudophakic macular edema (PME) is typically treated with nonsteroidal anti-inflammatory drugs (NSAIDs) initially, followed by steroids. Treatment with steroids becomes challenging in steroid responders. We report a case of PME treated with intravitreal
Simran, Suresh Ramchandani, Shubhangi Mahesh, Fatema Lokhandwala   +3 more
doaj   +1 more source