Results 41 to 50 of about 16,575 (212)

Vascular Acrosyndromes Associated With Prolonged Tumor Response in Advanced Lung Cancer Patients During Treatment With Antimetabolites: A Report of Two Cases

open access: yesFrontiers in Oncology, 2021
BackgroundPemetrexed and gemcitabine are both antimetabolites drugs approved in advanced non-small cell lung cancer (NSCLC). Their toxicity profile is well known. However, rare vascular side effects can occur such as vascular acrosyndromes and especially
Margaux Geier   +6 more
doaj   +1 more source

Mechanism of Action and Use of Radiomimetic Compounds : Part 1 – Alkylating Agents and Antimetabolites [PDF]

open access: yes, 2022
Radiomimetic substances are drugs producing similar symptoms in living organisms as ionising radiation does.  They constitute a special subgroup of carcinogen, mutagen, teratogen compounds; their common characteristic is to  cause DNA breaks and/or to ...
Deli, Gábor
core   +1 more source

Large Scale Screening of Rhizospheric Allelopathic Bacteria and Their Potential for the Biocontrol of Wheat-Associated Weeds

open access: yesAgronomy, 2020
Conventional weed control practices have generated serious issues related to the environment and human health. Therefore, there is a demand for the development of alternative techniques for sustainable agriculture.
Tasawar Abbas   +6 more
doaj   +1 more source

Apoptotic enteropathy caused by antimetabolites and TNF-α antagonists

open access: yes, 2014
AIMS: To investigate whether drugs others than mycophenolic acid and ipilimumab might cause graft-versus-host-like apoptotic enteropathy, the clinicopathological findings in four patients were examined who had developed watery diarrhoea and apoptotic ...
Rogler, Gerhard   +6 more
core   +1 more source

MODERN METHODS OF CONTROLLING WOUND HEALING AFTER FISTULIZING GLAUCOMA SURGERY. ANTI-INFLAMMATORY DRUGS AND NEW TRENDS

open access: yesOftalʹmologiâ, 2017
The  article  describes  modern approaches  for  controlling  wound  healing  after  fistulizing  glaucoma   surgery.  The  review  recounts international experience of steroidal and nonsteroidal anti-inflammatory drug and their efficacy research study ...
S. Yu. Petrov
doaj   +1 more source

Streptavidins Coordinate Biotin Sequestration and Self‐Resistance Within a Biotin‐Pathway Antibiotic Network

open access: yesAdvanced Science, EarlyView.
A conserved genomic region between two streptavidin genes in Streptomyces packages biosynthetic gene clusters for diverse biotin‐pathway antibiotics: acidomycin, stravidin, the new non‐proteinogenic amino acid ANDA, and the new BioA inhibitor α‐methyl‐KAPA.
Sumire Kurosawa   +8 more
wiley   +1 more source

Artificial Intelligence and Predictive Modelling for Precision Dosing of Immunosuppressants in Kidney Transplantation

open access: yesPharmaceuticals
Optimizing immunosuppressant dosing presents significant challenges in kidney transplantation due to narrow therapeutic ranges and considerable inter-patient pharmacokinetic differences.
Sholpan Altynova   +5 more
doaj   +1 more source

MODERN ONCO DRUG FOR INTERNAL USE

open access: yesФармация и фармакология (Пятигорск), 2018
Despite the development of biotherapy, chemotherapy remains one of the main methods of treatment of cancer patients. Currently, there are more than 100 anticancer drug substances, however, every year new drugs enter clinical practice and various ...
O. L. Orlova   +7 more
doaj   +1 more source

Syntheses of Antimetabolites [PDF]

open access: yes, 1970
In these studies several different types of antimetabolites were synthesized, and their biological effects were examined in various assay systems. More extensive investigations were done in microbial systems in which many of the compounds proved to be ...
Clifton, George Gil
core  

Role of Rutin in 5-Fluorouracil-Induced Intestinal Mucositis: Prevention of Histological Damage and Reduction of Inflammation and Oxidative Stress

open access: yesMolecules, 2020
Intestinal mucositis, characterized by inflammatory and/or ulcerative processes in the gastrointestinal tract, occurs due to cellular and tissue damage following treatment with 5-fluorouracil (5-FU).
Lázaro de Sousa Fideles   +19 more
doaj   +1 more source

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