Results 41 to 50 of about 17,951 (205)
Frontiers in Oncology, 2021 BackgroundPemetrexed and gemcitabine are both antimetabolites drugs approved in advanced non-small cell lung cancer (NSCLC). Their toxicity profile is well known. However, rare vascular side effects can occur such as vascular acrosyndromes and especially
Margaux Geier +6 more
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Agronomy, 2020 Conventional weed control practices have generated serious issues related to the environment and human health. Therefore, there is a demand for the development of alternative techniques for sustainable agriculture.
Tasawar Abbas +6 more
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Oftalʹmologiâ, 2017 The article describes modern approaches for controlling wound healing after fistulizing glaucoma surgery. The review recounts international experience of steroidal and nonsteroidal anti-inflammatory drug and their efficacy research study ...
S. Yu. Petrov
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Advanced Science, EarlyView.This work develops a metabolic sharing strategy that employs cytidine monophosphate (CMP) to competitively reprogram floxuridine (FUDR) pyrimidine metabolism in colorectal tumor cells. Elevated intracellular FdUMP induces nucleotide imbalance, drives mitochondrial DNA release and cGAS‐STING innate immune cascade activation, and potentiates robust ...
Chao Wang +10 more
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PharmaceuticalsOptimizing immunosuppressant dosing presents significant challenges in kidney transplantation due to narrow therapeutic ranges and considerable inter-patient pharmacokinetic differences.
Sholpan Altynova +5 more
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Syntheses of Antimetabolites [PDF]
, 1970 In these studies several different types of antimetabolites were synthesized, and their biological effects were examined in various assay systems. More extensive investigations were done in microbial systems in which many of the compounds proved to be ...
Clifton, George Gil
core
Clinical Pharmacology &Therapeutics, EarlyView.Pain and fever are common in pregnancy. Dipyrone is widely used in Europe, Latin America, and parts of Asia, but is banned in other countries due to concerns about agranulocytosis. Evidence on its safety in pregnancy remains limited and inconsistent. This study aimed to evaluate whether maternal dipyrone use during the first‐ and third‐trimesters is ...
Itamar Ben Shitrit +7 more
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MODERN ONCO DRUG FOR INTERNAL USE
Фармация и фармакология (Пятигорск), 2018 Despite the development of biotherapy, chemotherapy remains one of the main methods of treatment of cancer patients. Currently, there are more than 100 anticancer drug substances, however, every year new drugs enter clinical practice and various ...
O. L. Orlova +7 more
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Combined immunosuppressive therapy with low dose FK506 and antimetabolites in rat allogeneic heart transplantation [PDF]
, 1994 Following rat heterotopic heart allotransplantation, low to lethal doses of the antimetabolites mizoribine (MIZ), RS-61443 (RS), and AZA were given alone or in combination with subtherapeutic doses of FK506 (0.04 mg/kg/day) for 14 days after ...
Todo, S +6 more
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A proteomic investigation of forebrain regeneration in the leopard gecko (Eublepharis macularius)
Developmental Dynamics, EarlyView.Our investigation reveals ontogenetic, injury‐ and regeneration‐associated proteomic changes in the leopard gecko forebrain. Abstract Background The ability to replace lost or damaged neurons following an injury is termed reactive neurogenesis. Although reactive neurogenesis has been reported in several lizard species, the molecular mechanisms ...
Alexandra I. Noble +2 more
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