Results 41 to 50 of about 23,471 (208)

Risk of failing both methotrexate and mycophenolate mofetil from the First-line Antimetabolites as Steroid-sparing Treatment (FAST) uveitis trial

Journal of Ophthalmic Inflammation and Infection, 2023
Background The antimetabolites methotrexate (MTX) and mycophenolate mofetil (MMF) are commonly used as initial corticosteroid-sparing treatment for uveitis. There is little data examining risk factors for failing both MTX and MMF.
Amit K. Reddy, D. Claire Miller, Amol A. Sura, SR Rathinam, John A Gonzales, Radhika Thundikandy, Anuradha Kanakath, Bala Murugan, Rajesh Vedhanayaki, Lyndell L. Lim, Eric B. Suhler, Thuy Doan, Hassan A. Al-Dhibi, Debra A. Goldstein, Lourdes Arellanes-Garcia, Nisha R Acharya   +15 more
doaj   +1 more source

Multimodal Multiorgan‐on‐a‐Chip Platform for Probing Liver‐Tumor Interactions and Advancing Prodrug Screening

Advanced Science, EarlyView.
This work introduces a multimodal multi‐OoC platform that overcomes current limitations in liver‐tumor interaction studies and prodrug screening. By integrating dynamic microfluidic circuits, electrochemical sensing, and mass analysis, this platform enables non‐invasive, longitudinal monitoring of drug metabolism and hepatotoxicity, offering a ...
Dan Wang, Yisong Huang, Weijian Zhao, Tian Chen, Siyu Bai, Denghui Guo, Mengying Wang, Yaoyao Zhao, Liang Zhao, Guangsheng Guo, Xiayan Wang   +10 more
wiley   +1 more source

Chemotherapeutic Potential of Fluorouracil‐Platinum (IV) Prodrugs Against Cisplatin‐Resistant Colorectal Cancer Cells

Chemistry – A European Journal, EarlyView.
ABSTRACT Fluorouracil‐platinum(IV) prodrugs represent a novel class of multimechanistic chemotherapeutics with enhanced anticancer potential. The prodrugs PtIVP‐5FUMeOBut and PtIV56‐5FUMeOBut were actualized by derivatising the clinical drug 5‐fluorouracil (5FU) and coordinating it to platinum(IV) complexes, leveraging the established cytotoxicity of ...
Maria George Elias, Aleen Khoury, Shadma Fatima, Timothy J. Mann, Shawan Karan, Meena Mikhael, Paul de Souza, Christopher P. Gordon, Kieran F. Scott, Janice R. Aldrich‐Wright   +9 more
wiley   +1 more source

Artificial Intelligence and Predictive Modelling for Precision Dosing of Immunosuppressants in Kidney Transplantation

Pharmaceuticals
Optimizing immunosuppressant dosing presents significant challenges in kidney transplantation due to narrow therapeutic ranges and considerable inter-patient pharmacokinetic differences.
Sholpan Altynova, Timur Saliev, Aruzhan Asanova, Zhanna Kozybayeva, Saltanat Rakhimzhanova, Aidos Bolatov   +5 more
doaj   +1 more source

Genetic Relationships and Therapeutic Options for Relapsed Acute Lymphoblastic Leukemia [PDF]

, 2020
Acute lymphoblastic leukemia (ALL) is the most common form of cancer among children and can be lethal to the adult population. Though 80% of patients with ALL reach complete remission after treatment, about 20% of those diagnosed fail to remain cancer ...
Shertzer, Hailie
core   +1 more source

Metabolomics guides rational development of a simplified cell culture medium for drug screening against Trypanosoma brucei [PDF]

, 2013
n vitro culture methods underpin many experimental approaches to biology and drug discovery. The modification of established cell culture methods to make them more biologically relevant or to optimize growth is traditionally a laborious task.
Alsford, Alsford, Baltz, Barrett, Berger, Berger, Bitonti, Bowling, Bradley, Breitling, Brun, Brunda Nijagal, Creek, Creek, Creek, Darren J. Creek, de Koning, Dong-Hyun Kim, Drexler, Duszenko, Duszenko, Federico Rojas, Geary, Haanstra, Hasne, Hirumi, Hirumi, Hirumi, Jacobs, Keith R. Matthews, Kuettel, Kwon, Lanteri, Lanteri, Mashego, Michael P. Barrett, Mäser, Räz, Saunders, Scalbert, Scheltema, Scheltema, Seed, Sienkiewicz, Smith, Sumner, Sykes, t'Kindt, Tautenhahn, Vincent, Wang, Ward, Wilson, Winder, Wishart, Wu, Zaboikin, Zang, Zhang   +58 more
core   +2 more sources

Gut microbiota‐related modulation of immune mechanisms in post‐infarction remodelling and heart failure

ESC Heart Failure, Volume 12, Issue 2, Page 942-954, April 2025.
Abstract The immune system has long been recognized as a key driver in the progression of heart failure (HF). However, clinical trials targeting immune effectors have consistently failed to improve patient outcome across different HF aetiologies. The activation of the immune system in HF is complex, involving a broad network of pro‐inflammatory and ...
Johann Roessler, Friederike Zimmermann, Bettina Heidecker, Ulf Landmesser, Arash Haghikia   +4 more
wiley   +1 more source

MODERN ONCO DRUG FOR INTERNAL USE

Фармация и фармакология (Пятигорск), 2018
Despite the development of biotherapy, chemotherapy remains one of the main methods of treatment of cancer patients. Currently, there are more than 100 anticancer drug substances, however, every year new drugs enter clinical practice and various ...
O. L. Orlova, L. L. Nikolaeva, L. A. Korol, M. V. Dmitrieva, A. P. Polozkova, A. V. Lantsova, I. D. Gulyakin, N. A. Oborotova   +7 more
doaj   +1 more source

Role of Rutin in 5-Fluorouracil-Induced Intestinal Mucositis: Prevention of Histological Damage and Reduction of Inflammation and Oxidative Stress

Molecules, 2020
Intestinal mucositis, characterized by inflammatory and/or ulcerative processes in the gastrointestinal tract, occurs due to cellular and tissue damage following treatment with 5-fluorouracil (5-FU).
Lázaro de Sousa Fideles, João Antônio Leal de Miranda, Conceição da Silva Martins, Maria Lucianny Lima Barbosa, Helder Bindá Pimenta, Paulo Vitor de Souza Pimentel, Claudio Silva Teixeira, Marina Alves Sampaio Scafuri, Samuel de Osterno Façanha, João Erivan Façanha Barreto, Poliana Moreira de Medeiros Carvalho, Ariel Gustavo Scafuri, Joabe Lima Araújo, Jefferson Almeida Rocha, Icaro Gusmão Pinto Vieira, Nágila Maria Pontes Silva Ricardo, Matheus da Silva Campelo, Maria Elenir Nobre Pinho Ribeiro, Gerly Anne de Castro Brito, Gilberto Santos Cerqueira   +19 more
doaj   +1 more source

Health-related quality of life and depression among participants in the Sjögren's International Collaborative Clinical Alliance registry. [PDF]

, 2017
ObjectiveTo examine health-related quality of life (HRQoL) and depression among participants in an international Sjögren's syndrome (SS) registry, comparing those with and without SS.MethodsCross-sectional study of participants in the Sjögren's ...
Chou, Annie, Criswell, Lindsey A, Daniels, Troy E, Gonzales, John A, Shiboski, Caroline H, Shiboski, Stephen C   +5 more
core   +1 more source