Results 31 to 40 of about 16,575 (212)
CAQ Corner: Immune‐mediated complications
, 2022 Liver Transplantation, EarlyView.
Mary Thomson, John R. Lake
wiley +1 more source
Molecular Systems Biology, 2014 Genome‐scale metabolic models (GEMs) have proven useful as scaffolds for the integration of omics data for understanding the genotype–phenotype relationship in a mechanistic manner.
Rasmus Agren +5 more
doaj +1 more source
Angewandte Chemie, EarlyView.The carbocyclic Decitabine analog (cAzadC) incorporates as an antimetabolite weakly into the genome of growing tumor cells, where it triggers a genome‐wide demethylation and a surprisingly strong hydroxymethylation of cytosine, which translates into an efficient in vivo antitumor (AML) effect.
Maike Däther +17 more
wiley +2 more sources
Reduced Dose Methotrexate and Mycophenolate Mofetil in Noninfectious Uveitis: A Sub-Analysis from the First-Line Antimetabolites as Steroid Sparing Therapy (FAST) Trial. [PDF]
, 2023 PURPOSE: Some patients taking methotrexate (MTX) or mycophenolate mofetil (MMF) experience intolerable side effects at full doses. We evaluated whether dose reduction affected treatment outcomes in uveitis patients. METHODS: Subanalysis of the First-line
Kanakath, Anuradha +13 more
core +1 more source
Cancer Metabolism and Drug Resistance
Metabolites, 2015 Metabolic alterations, driven by genetic and epigenetic factors, have long been known to be associated with the etiology of cancer. Furthermore, accumulating evidence suggest that cancer metabolism is intimately linked to drug resistance, which is ...
Mahbuba Rahman, Mohammad Rubayet Hasan
doaj +1 more source
Variation of Cost among Anti-cancer Drugs Available in Indian Market [PDF]
Journal of Clinical and Diagnostic Research, 2016 Introduction: Although cancer remains a major health problem all over the world, its treatment is limited by affordability of patients in a developing country like India.
Bhanu Prakash Kolasani +2 more
doaj +1 more source
New Steroidal Selenides as Proapoptotic Factors
Molecules, 2023 Cytostatic and pro-apoptotic effects of selenium steroid derivatives against HeLa cells were determined. The highest cytostatic activity was shown by derivative 4 (GI50 25.0 µM, almost complete growth inhibition after three days of culture, and over 97 ...
Izabella Jastrzebska +7 more
doaj +1 more source
Xeloda as first-line therapy of metastatic colorectal cancer-our experience [PDF]
Archive of Oncology, 2002 BACKGROUND: Results of phase III clinical studies comparing efficacy of Xeloda vs. standard 5-FU/FA protocols as first line therapy of metastatic colorectal carcinoma (MCRC), have shown better efficacy of Xeloda, with less toxic adverse effects, apart ...
Kovčin Vladimir +4 more
doaj +1 more source
Frontiers in Immunology, 2020 Cationic antimicrobial peptides (AMPs) are active immune effectors of multicellular organisms and are also considered as new antimicrobial drug candidates.
Alexandro Rodríguez-Rojas +8 more
doaj +1 more source
Adenosine kinase of Trypanosoma brucei and its role in susceptibility to adenosine antimetabolites
, 2007 Trypanosoma brucei cannot synthesize purines de novo and relies on purine salvage from its hosts to build nucleic acids. With adenosine being a preferred purine source of bloodstream-form trypanosomes, adenosine kinase (AK; EC 2.7.1.20) is likely to be a
Önal, Pinar +3 more
core +1 more source