Novel Active Homo-Aza (Lactam) Steroidal Antimetabolites for the Treatment of Human Pancreatic and Colorectal Cancer [PDF]
PharmaceuticalsBackground: Colorectal and pancreatic cancers remain therapeutically challenging, with limitations in efficacy and limitations due to toxicity from conventional antimetabolites such as 5-fluorouracil (5-FU), methotrexate (MTX), and gemcitabine (GEM ...
Konstantinos E. Alifieris +12 more
doaj +3 more sources
Platinum-Nucleos(t)ide Compounds as Possible Antimetabolites for Antitumor/Antiviral Therapy: Properties and Perspectives [PDF]
Pharmaceutics, 2023 Nucleoside analogues (NAs) are a family of compounds which include a variety of purine and pyrimidine derivatives, widely used as anticancer and antiviral agents.
Federica De Castro +2 more
exaly +4 more sources
Folic Acid Antimetabolites (Antifolates): A Brief Review on Synthetic Strategies and Application Opportunities [PDF]
Molecules, 2022 Antimetabolites of folic acid represent a large group of drugs and drug candidates, including those for cancer chemotherapy. In this current review, the most common methods and approaches are presented for the synthesis of therapeutically significant ...
Igor S. Kovalev +5 more
doaj +2 more sources
Anti-VEGF agents with or without antimetabolites in trabeculectomy for glaucoma: a meta-analysis. [PDF]
PLoS ONE, 2014 PURPOSE: We aimed to evaluate the intraoperative application of antimetabolites compared with anti-vascular endothelial growth factor (VEGF) agents with or without antimetabolites in trabeculectomy (Trab) for glaucoma.
Qi Xiong +6 more
doaj +2 more sources
Non-coding RNA Research, 2018 Gemcitabine and pemetrexed are clinically approved antimetabolites for the therapy of mesothelioma diseases. These drugs are often applied in combination with platinum complexes and other drugs.
Bernhard Biersack
doaj +2 more sources
Risk of failing both methotrexate and mycophenolate mofetil from the First-line Antimetabolites as Steroid-sparing Treatment (FAST) uveitis trial [PDF]
Journal of Ophthalmic Inflammation and Infection, 2023 Background The antimetabolites methotrexate (MTX) and mycophenolate mofetil (MMF) are commonly used as initial corticosteroid-sparing treatment for uveitis. There is little data examining risk factors for failing both MTX and MMF.
Amit K. Reddy +15 more
doaj +2 more sources
Development of a high-throughput label-free method for enrichment of antimetabolite-resistant yeast strains using pico-litre agarose beads [PDF]
Applied Microbiology and BiotechnologyAntimetabolites, which are structural analogues of metabolites or carbon sources that exhibit toxicity by disrupting metabolism, can couple phenotypes of interest to growth and thereby facilitate the selection of relevant strains from large mutant pools ...
Sagarika B. Govindaraju +3 more
doaj +2 more sources
Molecular Systems Biology, 2014 Genome‐scale metabolic models (GEMs) have proven useful as scaffolds for the integration of omics data for understanding the genotype–phenotype relationship in a mechanistic manner.
Rasmus Agren +5 more
doaj +2 more sources
Steroidal Antimetabolites Protect Mice against Trypanosoma brucei
Molecules, 2022 Trypanosoma brucei, the causative agent for human African trypanosomiasis, is an emerging ergosterol-dependent parasite that produces chokepoint enzymes, sterol methyltransferases (SMT), not synthesized in their animal hosts that can regulate cell ...
Minu Chaudhuri +4 more
doaj +2 more sources
Frontiers in Plant Science, 2023 Halo blight is a plant disease that leads to a significant decrease in the yield of common bean crops and kiwi fruits. The infection is caused by Pseudomonas syringae pathovars that produce phaseolotoxin, an antimetabolite which targets arginine ...
Maciej Nielipinski +3 more
doaj +1 more source