Results 11 to 20 of about 23,471 (208)

Novel Active Homo-Aza (Lactam) Steroidal Antimetabolites for the Treatment of Human Pancreatic and Colorectal Cancer [PDF]

Pharmaceuticals
Background: Colorectal and pancreatic cancers remain therapeutically challenging, with limitations in efficacy and limitations due to toxicity from conventional antimetabolites such as 5-fluorouracil (5-FU), methotrexate (MTX), and gemcitabine (GEM ...
Konstantinos E. Alifieris, Panagiotis Dalezis, Sofia Sagredou, Ioanna A. Anastasiou, Maria Deligiorgi, Christos Siokatas, Nikolaos Spanakis, Konstantinos Almpanakis, Maria Voura, Kyriakos Orfanakos, Mihalis Panayiotidis, Vasiliki Sarli, Dimitrios T. Trafalis   +12 more
doaj   +2 more sources

Development of a high-throughput label-free method for enrichment of antimetabolite-resistant yeast strains using pico-litre agarose beads [PDF]

Applied Microbiology and Biotechnology
Antimetabolites, which are structural analogues of metabolites or carbon sources that exhibit toxicity by disrupting metabolism, can couple phenotypes of interest to growth and thereby facilitate the selection of relevant strains from large mutant pools ...
Sagarika B. Govindaraju, Thibaut J. Wenzel, Jack T. Pronk, Rinke J. van Tatenhove-Pel   +3 more
doaj   +2 more sources

Polymorphism in glutathione S-transferase P1 is associated with susceptibility to chemotherapyinduced leukemia [PDF]

, 2001
Glutathione S-transferases (GSTs) detoxify potentially mutagenic and toxic DNA-reactive electrophiles, including metabolites of several chemotherapeutic agents, some of which are suspected human carcinogens.
Akande, Ban, Brusamolino, Czerwinski, Czerwinski, Diamandidou, Dirven, Felix, Felix, Fisher, Gerson, GREENE, Grimwade, Harries, Johansson, Johansson, Kaldor, Kaldor, Kane, Kuga, Larson, Le Beau, Matsunaga, Miyazaki, Nakagawa, Naoe, O'Brien, Pandya, Panizo, Pearson, Pedersen-Bjergaard, Rivera, Rollinson, Roth, Ryberg, Sasai, Seidegard, Skibola, Sprenger, Srivastava, Sweeney, Tan, Travis, Travis, Travis, Watson, WILSON, Wolden, Woo, Zimniak   +49 more
core   +7 more sources

Combined immunosuppressive therapy with low dose FK506 and antimetabolites in rat allogeneic heart transplantation [PDF]

, 1994
Following rat heterotopic heart allotransplantation, low to lethal doses of the antimetabolites mizoribine (MIZ), RS-61443 (RS), and AZA were given alone or in combination with subtherapeutic doses of FK506 (0.04 mg/kg/day) for 14 days after ...
Fujisaki, S, Irish, W, Miyazawa, H, Murase, N, Starzl, TE, Tanabe, M, Todo, S   +6 more
core   +1 more source

CAQ Corner: Basic concepts of transplant immunology

, 2022
Liver Transplantation, EarlyView.
Amanda Cheung, Josh Levitsky
wiley   +1 more source

An Organofluorine Isoselenocyanate Analogue of Sulforaphane Affects Antimetabolite 5-Fluorouracil’s Anticancer Activity: A Perspective for New Combinatory Therapy in Triple-Negative Breast Cancer

Molecules, 2023
Antimetabolites, especially 5-fluorouracil, are commonly used clinically to treat breast, colon, and other cancers. However, their side effects and inefficiency in monotherapy have prompted further searches for new combinations.
Małgorzata Milczarek, Tomasz Cierpiał, Piotr Kiełbasiński, Milena Małecka-Giełdowska, Marta Świtalska, Joanna Wietrzyk, Maciej Mazur, Katarzyna Wiktorska   +7 more
doaj   +1 more source

CAQ Corner: Immune‐mediated complications

, 2022
Liver Transplantation, EarlyView.
Mary Thomson, John R. Lake
wiley   +1 more source

Comparison of remdesivir and favipiravir - the anti-Covid-19 agents mimicking purine RNA constituents

Biomedical Papers, 2022
By December 2019, humanity was challenged by a new infectious respiratory disease named coronavirus disease of 2019 or COVID-19. This is a viral infection based on the presence of the previously non-problematic coronavirus with assigned number 2.
Faiha M. Al-Ardhi, Ladislav Novotny, Adel Alhunayan, Naser F. Al-Tannak   +3 more
doaj   +1 more source

Microbial metal resistance and metabolism across dynamic landscapes: high-throughput environmental microbiology. [PDF]

, 2017
Multidimensional gradients of inorganic compounds influence microbial activity in diverse pristine and anthropogenically perturbed environments. Here, we suggest that high-throughput cultivation and genetics can be systematically applied to generate ...
Carlson, Hans, Coates, John, Deutschbauer, Adam   +2 more
core   +2 more sources

Interplay of non-coding RNAs and approved antimetabolites such as gemcitabine and pemetrexed in mesothelioma

Non-coding RNA Research, 2018
Gemcitabine and pemetrexed are clinically approved antimetabolites for the therapy of mesothelioma diseases. These drugs are often applied in combination with platinum complexes and other drugs.
Bernhard Biersack
doaj   +1 more source