Results 11 to 20 of about 15,247 (179)

Platinum-Nucleos(t)ide Compounds as Possible Antimetabolites for Antitumor/Antiviral Therapy: Properties and Perspectives

Pharmaceutics, 2023
Nucleoside analogues (NAs) are a family of compounds which include a variety of purine and pyrimidine derivatives, widely used as anticancer and antiviral agents.
Federica De Castro, Michele Benedetti, Francesco Paolo Fanizzi   +2 more
exaly   +3 more sources

Development of a high-throughput label-free method for enrichment of antimetabolite-resistant yeast strains using pico-litre agarose beads [PDF]

Applied Microbiology and Biotechnology
Antimetabolites, which are structural analogues of metabolites or carbon sources that exhibit toxicity by disrupting metabolism, can couple phenotypes of interest to growth and thereby facilitate the selection of relevant strains from large mutant pools ...
Sagarika B. Govindaraju, Thibaut J. Wenzel, Jack T. Pronk, Rinke J. van Tatenhove-Pel   +3 more
doaj   +2 more sources

Folic Acid Antimetabolites (Antifolates): A Brief Review on Synthetic Strategies and Application Opportunities

Molecules, 2022
Antimetabolites of folic acid represent a large group of drugs and drug candidates, including those for cancer chemotherapy. In this current review, the most common methods and approaches are presented for the synthesis of therapeutically significant ...
Igor S. Kovalev, Grigory V. Zyryanov, Sougata Santra, Adinath Majee, Mikhail V. Varaksin, Valery N. Charushin   +5 more
doaj   +1 more source

Structural analysis and molecular substrate recognition properties of Arabidopsis thaliana ornithine transcarbamylase, the molecular target of phaseolotoxin produced by Pseudomonas syringae

Frontiers in Plant Science, 2023
Halo blight is a plant disease that leads to a significant decrease in the yield of common bean crops and kiwi fruits. The infection is caused by Pseudomonas syringae pathovars that produce phaseolotoxin, an antimetabolite which targets arginine ...
Maciej Nielipinski, Agnieszka J. Pietrzyk-Brzezinska, Alexander Wlodawer, Bartosz Sekula   +3 more
doaj   +1 more source

Anti-VEGF agents with or without antimetabolites in trabeculectomy for glaucoma: a meta-analysis. [PDF]

PLoS ONE, 2014
PURPOSE: We aimed to evaluate the intraoperative application of antimetabolites compared with anti-vascular endothelial growth factor (VEGF) agents with or without antimetabolites in trabeculectomy (Trab) for glaucoma.
Qi Xiong, Zhiliang Li, Zhaohui Li, Yi Zhu, Sancar Abdulhalim, Ping Wang, Xiaojun Cai   +6 more
doaj   +1 more source

The Metabolomic Profile of the Essential Oil from Zanthoxylum caribaeum (syn. chiloperone) Growing in Guadeloupe FWI using GC × GC-TOFMS

Metabolites, 2022
The essential oil (EO) from the leaves of Zanthoxylum caribaeum (syn. Chiloperone) (Rutaceae) was studied previously for its acaricidal, antimicrobial, antioxidant, and insecticidal properties.
Lea Farouil, Ryan P. Dias, Gianni Popotte-Julisson, Garrick Bibian, Ahissan Innocent Adou, A. Paulina de la Mata, Muriel Sylvestre, James J. Harynuk, Gerardo Cebrián-Torrejón   +8 more
doaj   +1 more source

Cardiotoxic effects induced by the use of antimetabolites in the chemotherapy of oncological diseases

КардиоСоматика, 2021
In modern medical practice, the treatment of cancer is one of the most pressing issues. Many of the drugs used in the treatment of cancer have a toxic effect on the cardiovascular system of patients. The main clinical manifestations of cardiotoxicity are
Alina A. Aliab'eva, Galina S. Mal
doaj   +1 more source

Patterns of conjunctival and scleral regeneration after intraoperative application of cyclosporin A solution in rabbits with steroid-induced glaucoma

Бюллетень сибирской медицины, 2021
Aim. In an in vivo experiment, to study the effect of local intraoperative application of 0.05% cyclosporin A solution on the conjunctival and scleral regeneration after surgery on the rabbit eyes with steroid-induced  glaucoma.Materials and methods.
T. A. Zhigalskiaya, A. N. Dzyman, A. A. Krylova, O. I. Krivosheina, I. A. Khlusov   +4 more
doaj   +1 more source

Pathophysiological mechanisms of cardiotoxicity in chemotherapeutic agents

Russian Open Medical Journal, 2020
Certain success has been achieved in the treatment of cancer due to the development of various effective chemotherapeutic drugs. However, an increase in their effectiveness (aggressiveness) was associated with a growth of undesirable effects on the ...
Aleksey M. Chaulin, Olga E. Abashina, Dmitry V. Duplyakov   +2 more
doaj   +1 more source

Synthesis, Antitumor and Antiviral In Vitro Activities of New Benzotriazole-Dicarboxamide Derivatives

Frontiers in Chemistry, 2021
Cancer and viral infections continue to threaten humankind causing death worldwide. Hence, the discovery of new anticancer and antiviral agents still represents a major scientific goal.
Roberta Ibba, Sandra Piras, Paola Corona, Federico Riu, Roberta Loddo, Ilenia Delogu, Gabriella Collu, Giuseppina Sanna, Paola Caria, Tinuccia Dettori, Antonio Carta   +10 more
doaj   +1 more source