Results 21 to 30 of about 16,575 (212)

Cardiotoxic effects induced by the use of antimetabolites in the chemotherapy of oncological diseases

КардиоСоматика, 2021
In modern medical practice, the treatment of cancer is one of the most pressing issues. Many of the drugs used in the treatment of cancer have a toxic effect on the cardiovascular system of patients. The main clinical manifestations of cardiotoxicity are
Alina A. Aliab'eva, Galina S. Mal
doaj   +1 more source

Patterns of conjunctival and scleral regeneration after intraoperative application of cyclosporin A solution in rabbits with steroid-induced glaucoma

Бюллетень сибирской медицины, 2021
Aim. In an in vivo experiment, to study the effect of local intraoperative application of 0.05% cyclosporin A solution on the conjunctival and scleral regeneration after surgery on the rabbit eyes with steroid-induced  glaucoma.Materials and methods.
T. A. Zhigalskiaya, A. N. Dzyman, A. A. Krylova, O. I. Krivosheina, I. A. Khlusov   +4 more
doaj   +1 more source

Pathophysiological mechanisms of cardiotoxicity in chemotherapeutic agents

Russian Open Medical Journal, 2020
Certain success has been achieved in the treatment of cancer due to the development of various effective chemotherapeutic drugs. However, an increase in their effectiveness (aggressiveness) was associated with a growth of undesirable effects on the ...
Aleksey M. Chaulin, Olga E. Abashina, Dmitry V. Duplyakov   +2 more
doaj   +1 more source

Synthesis, Antitumor and Antiviral In Vitro Activities of New Benzotriazole-Dicarboxamide Derivatives

Frontiers in Chemistry, 2021
Cancer and viral infections continue to threaten humankind causing death worldwide. Hence, the discovery of new anticancer and antiviral agents still represents a major scientific goal.
Roberta Ibba, Sandra Piras, Paola Corona, Federico Riu, Roberta Loddo, Ilenia Delogu, Gabriella Collu, Giuseppina Sanna, Paola Caria, Tinuccia Dettori, Antonio Carta   +10 more
doaj   +1 more source

An Organofluorine Isoselenocyanate Analogue of Sulforaphane Affects Antimetabolite 5-Fluorouracil’s Anticancer Activity: A Perspective for New Combinatory Therapy in Triple-Negative Breast Cancer

Molecules, 2023
Antimetabolites, especially 5-fluorouracil, are commonly used clinically to treat breast, colon, and other cancers. However, their side effects and inefficiency in monotherapy have prompted further searches for new combinations.
Małgorzata Milczarek, Tomasz Cierpiał, Piotr Kiełbasiński, Milena Małecka-Giełdowska, Marta Świtalska, Joanna Wietrzyk, Maciej Mazur, Katarzyna Wiktorska   +7 more
doaj   +1 more source

Systemic anti-cancer therapy associated with the occurrence of peripheral neurotoxicity and, specifically, peripheral neuropathy. [PDF]

Int J Cancer
What's new? While the effectiveness of systemic anticancer therapy is well documented, it commonly causes severe toxicity. This study of the 467 systemic anticancer therapy agents currently approved globally for clinical and/or research purposes found that peripheral neurotoxicity is associated with 45% of classical chemotherapies, 21% of targeted ...
Higgins C, Gauthier LR, Smith BH, Colvin L.   +3 more
europepmc   +2 more sources

Comparison of remdesivir and favipiravir - the anti-Covid-19 agents mimicking purine RNA constituents

Biomedical Papers, 2022
By December 2019, humanity was challenged by a new infectious respiratory disease named coronavirus disease of 2019 or COVID-19. This is a viral infection based on the presence of the previously non-problematic coronavirus with assigned number 2.
Faiha M. Al-Ardhi, Ladislav Novotny, Adel Alhunayan, Naser F. Al-Tannak   +3 more
doaj   +1 more source

Antimetabolites as an adjunct to dacryocystorhinostomy for nasolacrimal duct obstruction [PDF]

, 2020
Background: Nasolacrimal duct obstruction (NLDO) is a condition that results in the overflow of tears (epiphora) or infection of the nasolacrimal sac (dacryocystitis).
Dinesh Selva, Selva, D, Benjamin J Cowling, Paul O Phelps, Cowling, BJ, Phelps, PO, Marcus M Marcet, Abariga, SA, Marcet, MM, Samuel A. Abariga   +9 more
core   +1 more source

CAQ Corner: Basic concepts of transplant immunology

, 2022
Liver Transplantation, EarlyView.
Amanda Cheung, Josh Levitsky
wiley   +1 more source

Modern Methods of Controlling Wound Healing after Fistulizing Glaucoma Surgery. Risk Factors and Antimetabolites

Oftalʹmologiâ, 2017
The article describes modern approaches to controlling wound healing after fistulizing glaucoma surgery. It provides a classification of refractory glaucoma degrees and summarizes risk factors for excessive scarring. Author describes various applications
S. Yu. Petrov
doaj   +1 more source