Results 11 to 20 of about 351,657 (267)

A Mitochondrial Perspective on Noncommunicable Diseases

Biomedicines, 2023
Mitochondria are the center of energy metabolism in eukaryotic cells and play a central role in the metabolism of living organisms. Mitochondrial diseases characterized by defects in oxidative phosphorylation are the most common congenital diseases ...
Yifan Zheng, Jing Zhang, Xiaohong Zhu, Yuanjuan Wei, Wuli Zhao, Shuyi Si, Yan Li   +6 more
doaj   +1 more source

Potent antiplasmodial extracts and fractions from Terminalia mantaly and Terminalia superba

Malaria Journal, 2018
Background The emergence and spread of malaria parasites resistant to artemisinin-based combination therapy stresses the need for novel drugs against malaria.
Cedric D. J. Mbouna, Rufin M. T. Kouipou, Rodrigue Keumoe, Lauve R. Y. Tchokouaha, Patrick V. T. Fokou, Brice M. T. Tali, Dinkar Sahal, Fabrice F. Boyom   +7 more
doaj   +1 more source

Polymyxin resistance caused by large-scale genomic inversion due to IS26 intramolecular translocation in Klebsiella pneumoniae

Acta Pharmaceutica Sinica B, 2023
Polymyxin B and polymyxin E (colistin) are presently considered the last line of defense against human infections caused by multidrug-resistant Gram-negative organisms such as carbapenemase-producer Enterobacterales, Acinetobacter baumannii, and ...
Haibin Li, Lang Sun, Han Qiao, Zongti Sun, Penghe Wang, Chunyang Xie, Xinxin Hu, Tongying Nie, Xinyi Yang, Guoqing Li, Youwen Zhang, Xiukun Wang, Zhuorong Li, Jiandong Jiang, Congran Li, Xuefu You   +15 more
doaj   +1 more source

Fluoroquinolone Antimicrobial Agents [PDF]

New England Journal of Medicine, 1989
The fluoroquinolones, a new class of potent orally absorbed antimicrobial agents, are reviewed, considering structure, mechanisms of action and resistance, spectrum, variables affecting activity in vitro, pharmacokinetic properties, clinical efficacy, emergence of resistance, and tolerability. The primary bacterial target is the enzyme deoxyribonucleic
D C, Hooper, J S, Wolfson
openaire   +3 more sources

Synthesis and Evolution of Berberine Derivatives as a New Class of Antiviral Agents against Enterovirus 71 through the MEK/ERK Pathway and Autophagy

Molecules, 2018
Taking berberine (BBR) as the lead, 23 new BBR derivatives were synthesized and examined for their antiviral activities against four different genotype enterovirus 71 (EV71) strains with a cytopathic effect (CPE) assay.
Yan-Xiang Wang, Lu Yang, Hui-Qiang Wang, Xiao-Qiang Zhao, Ting Liu, Ying-Hong Li, Qing-Xuan Zeng, Yu-Huan Li, Dan-Qing Song   +8 more
doaj   +1 more source

Synthesis and Structure–Activity Relationship of Palmatine Derivatives as a Novel Class of Antibacterial Agents against Helicobacter pylori

Molecules, 2020
Taking palmatine (PMT) as the lead, 20 new PMT derivatives were synthesized and examined for their antibacterial activities against six tested metronidazole (MTZ)-resistant Helicobacter pylori (H. pylori) strains.
Tianyun Fan, Xixi Guo, Qingxuan Zeng, Wei Wei, Xuefu You, Jing Pang, Yanxiang Wang, Danqing Song   +7 more
doaj   +1 more source

Characterization of a hypervirulent multidrug-resistant ST23 Klebsiella pneumoniae carrying a blaCTX-M-24 IncFII plasmid and a pK2044-like plasmid

Journal of Global Antimicrobial Resistance, 2020
Objective: To characterise a multidrug-resistant hypervirulent Klebsiella pneumoniae (MDR-hvKp) strain (Kpn1693) isolated from the sputum of a 67-year-old male patient diagnosed as having bronchiectasis with infection in Northern China.
Yan Yang, Xue Li, Youwen Zhang, Jianhua Liu, Xinxin Hu, Tongying Nie, Xinyi Yang, Xiukun Wang, Congran Li, Xuefu You   +9 more
doaj   +1 more source

Clinical and microbiological characteristics of hypervirulent Klebsiella pneumoniae (hvKp) in a hospital from North China

Journal of Infection in Developing Countries, 2020
Introduction: The clinical and molecular characteristics of hypervirulent Klebsiella pneumoniae (hvKp) in various provinces of China have been reported, however, there have been few reports in Hebei Province, North China.
Yan Yang, Jian-Hua Liu, Xin-Xin Hu, Wei Zhang, Tong-Ying Nie , Xin-Yi Yang, Xiu-Kun Wang, Cong-Ran Li, Xue-Fu You   +8 more
doaj   +1 more source

ML364 exerts the broad-spectrum antivirulence effect by interfering with the bacterial quorum sensing system

Frontiers in Microbiology, 2022
Antivirulence strategy has been developed as a nontraditional therapy which would engender a lower evolutionary pressure toward the development of antimicrobial resistance.
Youwen Zhang, Limin Dong, Lang Sun, Xinxin Hu, Xiukun Wang, Tongying Nie, Xue Li, Penghe Wang, Pengbo Pang, Jing Pang, Xi Lu, Kaihu Yao, Xuefu You   +12 more
doaj   +1 more source

Evaluation and mechanism study of Pien Tze Huang against EV-A71 infection

Frontiers in Pharmacology, 2023
Hand, foot, and mouth disease (HFMD) caused by enterovirus A71 (EV-A71) infection, currently lacks specific preventive and therapeutic interventions. Here, we demonstrated that Pien Tze Huang (PZH) could dose-dependently inhibit EV-A71 replication at the
Huiqiang Wang, Fenbei Chen, Shicong Wang, Yuhuan Li, Ting Liu, Yinghong Li, Hongbin Deng, Jingwen Dong, Jing Pang, Danqing Song, Dousheng Zhang, Juan Yu, Yanxiang Wang   +12 more
doaj   +1 more source