Results 21 to 30 of about 351,657 (267)

Evolution and Antibacterial Evaluation of 8-Hydroxy-cycloberberine Derivatives as a Novel Family of Antibacterial Agents Against MRSA

Molecules, 2019
Twenty-five new derivatives of 8-hydroxycycloberberine (1) were synthesized and evaluated for their activities against Gram-positive bacteria, taking 1 as the lead.
Yuan-Shuai Yang, Wei Wei, Xin-Xin Hu, Sheng Tang, Jing Pang, Xue-Fu You, Tian-Yun Fan, Yan-Xiang Wang, Dan-Qing Song   +8 more
doaj   +1 more source

Identification of a Compound That Inhibits the Growth of Gram-Negative Bacteria by Blocking BamA–BamD Interaction

Frontiers in Microbiology, 2020
The demand for novel antibiotics is imperative for drug-resistant Gram-negative bacteria which causes diverse intractable infection disease in clinic. Here, a comprehensive screening was implemented to identify potential agents that disrupt the assembly ...
Yan Li, Xiaohong Zhu, Jing Zhang, Yuan Lin, Yuan Lin, Xuefu You, Minghua Chen, Yanchang Wang, Ningyu Zhu, Shuyi Si   +9 more
doaj   +1 more source

Efficacy of Three Povidone Iodine Formulations against Cutibacterium acnes Assessed through In Vitro Studies: A Preliminary Study

Antibiotics, 2022
Cutibacterium acnes (C. acnes, formerly known as Propionibacterium acnes) is the major causative agent of prosthetic joint infections (PJI). Treatment of PJI with antibiotics is difficult due to antibiotic resistance and adverse side effects on patients’
Maxime Pichon, Christophe Burucoa, Victor Evplanov, Filippo Favalli   +3 more
doaj   +1 more source

Cirsimaritin inhibits influenza A virus replication by downregulating the NF-κB signal transduction pathway

Virology Journal, 2018
Background Artemisia scoparia Waldst and Kit is a famous traditional Chinese medicine widely distributed in Xinjiang, China. Flavonoids extracted from it exhibits inhibitory activities against several influenza virus strains.
Haiyan Yan, Huiqiang Wang, Linlin Ma, Xueping Ma, Jinqiu Yin, Shuo Wu, Hua Huang, Yuhuan Li   +7 more
doaj   +1 more source

Synthesis and Biological Evaluation of Quinoline Derivatives as a Novel Class of Broad-Spectrum Antibacterial Agents

Molecules, 2019
Nineteen new quinoline derivatives were prepared via the Mannich reaction and evaluated for their antibacterial activities against both Gram-positive (G+) and Gram-negative (G−) bacteria, taking compound 1 as the lead.
Hai-Gen Fu, Zhi-Wen Li, Xin-Xin Hu, Shu-Yi Si, Xue-Fu You, Sheng Tang, Yan-Xiang Wang, Dan-Qing Song   +7 more
doaj   +1 more source

Identification of a Small Molecule That Inhibits the Interaction of LPS Transporters LptA and LptC

Antibiotics, 2022
The need for novel antibiotics has become imperative with the increasing prevalence of antibiotic resistance in Gram-negative bacteria in clinics. Acting as a permeability barrier, lipopolysaccharide (LPS) protects Gram-negative bacteria against drugs ...
Xiaowei Dai, Min Yuan, Yu Lu, Xiaohong Zhu, Chao Liu, Yifan Zheng, Shuyi Si, Lijie Yuan, Jing Zhang, Yan Li   +9 more
doaj   +1 more source

Macrolides: A Canadian Infectious Disease Society Position Paper

Canadian Journal of Infectious Diseases, 2001
Since the introduction of erythromycin in 1965, no new compounds from the macrolide antimicrobial class were licensed in Canada until the 1990s. Clarithromycin and azithromycin, since their introduction, have become important agents for treating a number
S McKenna, GA Evans, Canadian Infectious Disease Society Antimicrobial Agents Committee   +2 more
doaj   +1 more source

Ethnomedicinal Uses, Phytochemistry, and Pharmacological Activity of the Irvingia Species

Drugs and Drug Candidates, 2023
Plants belonging to the genus Irvingia are widespread across the African and Southeast Asian regions of the world. Irvingia gabonensis, Irvingia malayana, and Irvingia grandifolia are among the commonly used species in ethnomedicine, especially in Africa.
Branly-Natalien Nguena-Dongue, Boniface Pone Kamdem, Paul Keilah Lunga, Fabrice Fekam Boyom   +3 more
doaj   +1 more source

Preliminary Structure–Activity Relationship Study of the MMV Pathogen Box Compound MMV675968 (2,4-Diaminoquinazoline) Unveils Novel Inhibitors of Trypanosoma brucei brucei

Molecules, 2022
New drugs are urgently needed for the treatment of human African trypanosomiasis (HAT). In line with our quest for novel inhibitors of trypanosomes, a small library of analogs of the antitrypanosomal hit (MMV675968) available at MMV as solid materials ...
Darline Dize, Rolland Bantar Tata, Rodrigue Keumoe, Rufin Marie Kouipou Toghueo, Mariscal Brice Tchatat, Cyrille Ngansop Njanpa, Vianey Claire Tchuenguia, Lauve Tchokouaha Yamthe, Patrick Valere Tsouh Fokou, Benoît Laleu, James Duffy, Ozlem Tastan Bishop, Fabrice Fekam Boyom   +12 more
doaj   +1 more source

New alternative therapeutic strategies against Pseudomonas aeruginosa, an opportunistic multi-resistant pathogen with a myriad of virulence factors

Journal of Infection in Developing Countries, 2023
Pseudomonas aeruginosa (PA) has emerged as a significant cause of Gram-negative infections, particularly in patients with impaired host defenses. It is one of the six ESKAPE pathogens that majorly cause severe nosocomial infections.
Benzaarate Ihssane, Elotmani Fatima, Khazaz Aboubakr, Mohammed Timinouni, Nayme Kaotar   +4 more
doaj   +1 more source