Results 21 to 30 of about 350,633 (266)

ML364 exerts the broad-spectrum antivirulence effect by interfering with the bacterial quorum sensing system

Frontiers in Microbiology, 2022
Antivirulence strategy has been developed as a nontraditional therapy which would engender a lower evolutionary pressure toward the development of antimicrobial resistance.
Youwen Zhang, Limin Dong, Lang Sun, Xinxin Hu, Xiukun Wang, Tongying Nie, Xue Li, Penghe Wang, Pengbo Pang, Jing Pang, Xi Lu, Kaihu Yao, Xuefu You   +12 more
doaj   +1 more source

Peptide Antimicrobial Agents [PDF]

Clinical Microbiology Reviews, 2006
SUMMARYAntimicrobial host defense peptides are produced by all complex organisms as well as some microbes and have diverse and complex antimicrobial activities. Collectively these peptides demonstrate a broad range of antiviral and antibacterial activities and modes of action, and it is important to distinguish between direct microbicidal and indirect ...
Håvard, Jenssen, Pamela, Hamill, Robert E W, Hancock   +2 more
openaire   +2 more sources

Clinical and microbiological characteristics of hypervirulent Klebsiella pneumoniae (hvKp) in a hospital from North China

Journal of Infection in Developing Countries, 2020
Introduction: The clinical and molecular characteristics of hypervirulent Klebsiella pneumoniae (hvKp) in various provinces of China have been reported, however, there have been few reports in Hebei Province, North China.
Yan Yang, Jian-Hua Liu, Xin-Xin Hu, Wei Zhang, Tong-Ying Nie , Xin-Yi Yang, Xiu-Kun Wang, Cong-Ran Li, Xue-Fu You   +8 more
doaj   +1 more source

Evaluation and mechanism study of Pien Tze Huang against EV-A71 infection

Frontiers in Pharmacology, 2023
Hand, foot, and mouth disease (HFMD) caused by enterovirus A71 (EV-A71) infection, currently lacks specific preventive and therapeutic interventions. Here, we demonstrated that Pien Tze Huang (PZH) could dose-dependently inhibit EV-A71 replication at the
Huiqiang Wang, Fenbei Chen, Shicong Wang, Yuhuan Li, Ting Liu, Yinghong Li, Hongbin Deng, Jingwen Dong, Jing Pang, Danqing Song, Dousheng Zhang, Juan Yu, Yanxiang Wang   +12 more
doaj   +1 more source

Identification of a Compound That Inhibits the Growth of Gram-Negative Bacteria by Blocking BamA–BamD Interaction

Frontiers in Microbiology, 2020
The demand for novel antibiotics is imperative for drug-resistant Gram-negative bacteria which causes diverse intractable infection disease in clinic. Here, a comprehensive screening was implemented to identify potential agents that disrupt the assembly ...
Yan Li, Xiaohong Zhu, Jing Zhang, Yuan Lin, Yuan Lin, Xuefu You, Minghua Chen, Yanchang Wang, Ningyu Zhu, Shuyi Si   +9 more
doaj   +1 more source

Efficacy of Three Povidone Iodine Formulations against Cutibacterium acnes Assessed through In Vitro Studies: A Preliminary Study

Antibiotics, 2022
Cutibacterium acnes (C. acnes, formerly known as Propionibacterium acnes) is the major causative agent of prosthetic joint infections (PJI). Treatment of PJI with antibiotics is difficult due to antibiotic resistance and adverse side effects on patients’
Maxime Pichon, Christophe Burucoa, Victor Evplanov, Filippo Favalli   +3 more
doaj   +1 more source

Evolution and Antibacterial Evaluation of 8-Hydroxy-cycloberberine Derivatives as a Novel Family of Antibacterial Agents Against MRSA

Molecules, 2019
Twenty-five new derivatives of 8-hydroxycycloberberine (1) were synthesized and evaluated for their activities against Gram-positive bacteria, taking 1 as the lead.
Yuan-Shuai Yang, Wei Wei, Xin-Xin Hu, Sheng Tang, Jing Pang, Xue-Fu You, Tian-Yun Fan, Yan-Xiang Wang, Dan-Qing Song   +8 more
doaj   +1 more source

Cirsimaritin inhibits influenza A virus replication by downregulating the NF-κB signal transduction pathway

Virology Journal, 2018
Background Artemisia scoparia Waldst and Kit is a famous traditional Chinese medicine widely distributed in Xinjiang, China. Flavonoids extracted from it exhibits inhibitory activities against several influenza virus strains.
Haiyan Yan, Huiqiang Wang, Linlin Ma, Xueping Ma, Jinqiu Yin, Shuo Wu, Hua Huang, Yuhuan Li   +7 more
doaj   +1 more source

Identification of a Small Molecule That Inhibits the Interaction of LPS Transporters LptA and LptC

Antibiotics, 2022
The need for novel antibiotics has become imperative with the increasing prevalence of antibiotic resistance in Gram-negative bacteria in clinics. Acting as a permeability barrier, lipopolysaccharide (LPS) protects Gram-negative bacteria against drugs ...
Xiaowei Dai, Min Yuan, Yu Lu, Xiaohong Zhu, Chao Liu, Yifan Zheng, Shuyi Si, Lijie Yuan, Jing Zhang, Yan Li   +9 more
doaj   +1 more source

Ethnomedicinal Uses, Phytochemistry, and Pharmacological Activity of the Irvingia Species

Drugs and Drug Candidates, 2023
Plants belonging to the genus Irvingia are widespread across the African and Southeast Asian regions of the world. Irvingia gabonensis, Irvingia malayana, and Irvingia grandifolia are among the commonly used species in ethnomedicine, especially in Africa.
Branly-Natalien Nguena-Dongue, Boniface Pone Kamdem, Paul Keilah Lunga, Fabrice Fekam Boyom   +3 more
doaj   +1 more source