Results 31 to 40 of about 350,633 (266)

Macrolides: A Canadian Infectious Disease Society Position Paper

Canadian Journal of Infectious Diseases, 2001
Since the introduction of erythromycin in 1965, no new compounds from the macrolide antimicrobial class were licensed in Canada until the 1990s. Clarithromycin and azithromycin, since their introduction, have become important agents for treating a number
S McKenna, GA Evans, Canadian Infectious Disease Society Antimicrobial Agents Committee   +2 more
doaj   +1 more source

Synthesis and Biological Evaluation of Quinoline Derivatives as a Novel Class of Broad-Spectrum Antibacterial Agents

Molecules, 2019
Nineteen new quinoline derivatives were prepared via the Mannich reaction and evaluated for their antibacterial activities against both Gram-positive (G+) and Gram-negative (G−) bacteria, taking compound 1 as the lead.
Hai-Gen Fu, Zhi-Wen Li, Xin-Xin Hu, Shu-Yi Si, Xue-Fu You, Sheng Tang, Yan-Xiang Wang, Dan-Qing Song   +7 more
doaj   +1 more source

Preliminary Structure–Activity Relationship Study of the MMV Pathogen Box Compound MMV675968 (2,4-Diaminoquinazoline) Unveils Novel Inhibitors of Trypanosoma brucei brucei

Molecules, 2022
New drugs are urgently needed for the treatment of human African trypanosomiasis (HAT). In line with our quest for novel inhibitors of trypanosomes, a small library of analogs of the antitrypanosomal hit (MMV675968) available at MMV as solid materials ...
Darline Dize, Rolland Bantar Tata, Rodrigue Keumoe, Rufin Marie Kouipou Toghueo, Mariscal Brice Tchatat, Cyrille Ngansop Njanpa, Vianey Claire Tchuenguia, Lauve Tchokouaha Yamthe, Patrick Valere Tsouh Fokou, Benoît Laleu, James Duffy, Ozlem Tastan Bishop, Fabrice Fekam Boyom   +12 more
doaj   +1 more source

New alternative therapeutic strategies against Pseudomonas aeruginosa, an opportunistic multi-resistant pathogen with a myriad of virulence factors

Journal of Infection in Developing Countries, 2023
Pseudomonas aeruginosa (PA) has emerged as a significant cause of Gram-negative infections, particularly in patients with impaired host defenses. It is one of the six ESKAPE pathogens that majorly cause severe nosocomial infections.
Benzaarate Ihssane, Elotmani Fatima, Khazaz Aboubakr, Mohammed Timinouni, Nayme Kaotar   +4 more
doaj   +1 more source

Antimicrobial Peptides as Therapeutic Agents [PDF]

International Journal of Microbiology, 2012
In developing this special issue, we sought to raise awareness of the potential of antimicrobial peptides (AMPs) for clinical use and to highlight recent developments in the field. The issue contains research articles covering the full spectrum of contemporary work, ranging from the rational design of synthetic peptides and discovery of bacteriocins ...
Upton, Mathew, Cotter, Paul, Tagg, John
openaire   +3 more sources

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

In vitro and in vivo activity of d-serine in combination with β-lactam antibiotics against methicillin-resistant Staphylococcus aureus

Acta Pharmaceutica Sinica B, 2019
As d-amino acids play important roles in the physiological metabolism of bacteria, combination of d-amino acids with antibiotics may provide synergistic antibacterial activity.
Qing Wang, Yuemeng Lv, Jing Pang, Xue Li, Xi Lu, Xiukun Wang, Xinxin Hu, Tongying Nie, Xinyi Yang, Yan Q. Xiong, Jiandong Jiang, Congran Li, Xuefu You   +12 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

In Vivo Antiplasmodial Activity of Terminalia mantaly Stem Bark Aqueous Extract in Mice Infected by Plasmodium berghei

Journal of Parasitology Research, 2020
Background. Terminalia mantaly is used in Cameroon traditional medicine to treat malaria and related symptoms. However, its antiplasmodial efficacy is still to be established. Objectives.
Mariscal Brice Tchatat Tali, Cedric Derick Jiatsa Mbouna, Lauve Rachel Yamthe Tchokouaha, Patrick Valere Tsouh Fokou, Jaures Marius Tsakem Nangap, Rodrigue Keumoe, Alvine Ngoutane Mfopa, Issakou Bakarnga-via, Raceline Gounoue Kamkumo, Fabrice Fekam Boyom   +9 more
doaj   +1 more source